Results 111 to 120 of about 25,727 (222)

Molecular and biochemical characterizations of a Fasciola gigantica retinoid X receptor-α isoform A (FgRXRα-A)

Scientific Reports
Fascioliasis is a parasitic infection in animals and humans caused by the parasitic flatworm genus Fasciola, which has two major species, F. hepatica and F. gigantica.
Nattaya Torungkitmangmi, Pathanin Chantree, Salisa Chaimon, Parisa Prathaphan, Jittiporn Ruangtong, Amornrat Geadkaew-Krenc, Phornphan Sornchuer, Bumpenporn Sanannam, Nattaya Thongsepee, Viriya Pankao, Poom Adisakwattana, Pongsakorn Martviset   +11 more
doaj   +1 more source

Enhancing human osteoblast to osteocyte-like cell differentiation using 25-hydroxyvitamin D3 and all-trans retinoic acid combination

European Cells & Materials
Background: The individual effects of the 25-hydroxyvitamin D3 (25(OH)D3) and all-trans retinoic acid (ATRA) on osteogenesis have been studied in two-dimensional (2D) in vitro models, but the combined effect of these vitamins remains largely unexplored ...
A Munir, AE Agger, A Samara, JE Reseland, LB Solberg   +4 more
doaj   +1 more source

A Novel Tight Junction–Nuclear Receptor Signaling Pathway Regulating Cancer Progression

Pathology International, EarlyView.
ABSTRACT Nuclear receptors (NRs) are lipid ligand‐binding transcription factors, with 48 members having been identified in humans to date. They are involved in diverse physiological processes, including development and homeostasis, and are also implicated in the pathogenesis of various diseases, most notably cancer.
Kotaro Sugimoto, Hideki Chiba
wiley   +1 more source

ENHO, RXRA, and LXRA polymorphisms and dyslipidaemia, related comorbidities and survival in haemodialysis patients

BMC Medical Genetics, 2018
Background The energy homeostasis-associated gene (ENHO), retinoid X receptor alpha gene (RXRA), and liver X receptor alpha gene (LXRA) are involved in adipogenic/lipogenic regulation.
Alicja E. Grzegorzewska, Leszek Niepolski, Monika K. Świderska, Adrianna Mostowska, Ireneusz Stolarek, Wojciech Warchoł, Marek Figlerowicz, Paweł P. Jagodziński   +7 more
doaj   +1 more source

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 100, Issue 9, Page 1603-1628, September 2025.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov, Trilokraj Tejasvi, Ryan A. Wilcox   +2 more
wiley   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, Volume 45, Issue 5, Page 1307-1322, September 2025.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

The Vertebral Column of Flatfish: A Review

Reviews in Aquaculture, Volume 17, Issue 4, September 2025.
ABSTRACT Flatfish (Pleuronectiformes) encompass fascinating fish species known for their high gastronomical value, rearing performances, and market prices, which attract both economic and scientific interest. Despite these attributes, flatfish exhibit unique morphological, developmental, and biological features, as well as distinctive swimming ...
A. M. de Azevedo, A. P. Losada, S. Vázquez, P. E. Witten, M. I. Quiroga, P. J. Gavaia   +5 more
wiley   +1 more source

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

Microbiota–Host Interactions: Exploring Their Dynamics and Contributions to Human Diseases

MicrobiologyOpen, Volume 14, Issue 4, August 2025.
Bacterial dysbiosis results from microbiota imbalances, diet, lifestyle, and other factors that lead to conditions such as IBS, IBD, acne, dermatitis, and dental diseases. The current therapeutic approaches include probiotics, prebiotics, synbiotics, microbiota transplantation, and phage therapy.
Siau Wui Chin, Zheng Yao Low, Wei Qi Tan, Adzzie Shazleen Azman   +3 more
wiley   +1 more source

A coarse‐grained model for disordered proteins under crowded conditions

Protein Science, Volume 34, Issue 8, August 2025.
Abstract Macromolecular crowding may strongly affect the dynamics and function of proteins, with intrinsically disordered proteins being particularly sensitive to their crowded environment. To understand the influences of crowding on chain compaction and phase separation (PS) behavior of disordered proteins, both experiments with synthetic crowders ...
Arriën Symon Rauh, Giulio Tesei, Kresten Lindorff‐Larsen   +2 more
wiley   +1 more source