Results 171 to 180 of about 25,727 (222)

Role of Nuclear Receptors on the Progression of Multiple Sclerosis: A Review. [PDF]

Cell Mol Neurobiol
Babaalizadeh B, Kalaki-Jouybari F, Abarghooi-Kahaki F, Afkhami H, Razavi ZS.   +4 more
europepmc   +1 more source

Effects of Retinol, Natural Pea Peptide and Antioxidant Blend in a Topical Formulation: In Vitro and Clinical Evidence. [PDF]

Dermatol Ther (Heidelb)
Cook B, Riggs M, Holley KC, Knaggs H, Diwakar G, Lephart ED.   +5 more
europepmc   +1 more source

Mechanistic Insights Into <i>Ganoderma Lucidum</i> for Diabetes Treatment via Network Pharmacology and Validation. [PDF]

Diabetes Metab Syndr Obes
Guo S, Yang L, Zhou J, Luo W, Nie B, Zhong X, Liu D, Kang X.   +7 more
europepmc   +1 more source

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Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha.

Biochemical and Biophysical Research Communications, 2014
NF-E2 P45-related factor 2 (Nrf2) is a key transcription factor that controls genes encoding cytoprotective and detoxifying enzymes through antioxidant response elements (AREs) in their regulatory regions. We reported recently that retinoid X receptor alpha (RXRα) inhibits Nrf2 function by direct interaction with the Neh7 domain of Nrf2 in a ligand ...
Jia-guo Wu, Hongyan Wang, Xiuwen Tang
semanticscholar   +4 more sources

Vitamin D Receptor and Retinoid X Receptor Alpha in Melanocytic Benign Lesions and Melanoma

The American Journal of Dermatopathology, 2023
Abstract: Vitamin D receptor (VDR) exerts its biological effects when it heterodimerizes to a nuclear receptor of the retinoid family called retinoid X receptor α (RXRα), stimulating or inhibiting DNA transcription. VDR stimulation by vitamin D analogs led to in vitro antiproliferative effects, and experimental RXRα knockout led to loss of ...
Juliana Polizel Ocanha Xavier, José Cândido Caldeira Xavier, Márcia Guimarães da Silva, Mariângela Esther Alencar Marques   +3 more
openaire   +2 more sources

Identification and characterization of the human retinoid X receptor alpha gene promoter

Gene, 2006
Retinoid X receptors (RXRs) comprise a family of nuclear retinoid activated transcription factors that are members of the steroid hormone receptor superfamily. RXRs are obligate heterodimerization partners with several other hormone receptor family members, making them critical mediators of a wide range of signaling pathways.
Robert M. Chamberlain, Weihong Yin, John L. Clifford, Xiulan Yang, Jennifer N. Roberts, Guojun Li, David Hewett-Emmett, Scott M. Lippman   +7 more
openaire   +3 more sources

Localization of the retinoid X receptor alpha gene (RXRA) to chromosome 9q34

Annals of Human Genetics, 1993
SummaryThe retinoid X receptor α is one of a number of retinoic acid receptors which are members of the steroid/thyroid hormone superfamily. Localization of RXRA was achieved using the polymerase chain reaction on a panel of somatic cell hybrids. A cosmid clone was isolated using the RXRA PCR product, and this was used to further localize the gene by ...
Malcolm A. Ferguson-Smith, Jude Fitzgibbon, Ellen Solomon, D.R. Goudie, K. A. Jones, Jonathan Wolfe, Karen Woodward, Susan Povey   +7 more
openaire   +3 more sources

Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce β-Amyloid Plaques in Alzheimer's Disease Mouse Model.

Molecular Pharmaceutics, 2018
Bexarotene, an agonist of retinoid X receptor alpha (RXRα), has been shown to increase the expression of apoE, ABCA1, and ABCG1 by activating RXR/LXR and RXR/PPAR heterodimers, resulting in amyloid β (Aβ)-protein clearance in the brain of an Alzheimer's ...
Gaoang Ren, Wei Bao, Zhiping Zeng, Weidong Zhang, Ce Shang, Maosi Wang, Ying Su, Xiao-kun Zhang, Hu Zhou   +8 more
semanticscholar   +1 more source

Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.

Molecular Pharmacology, 2000
In this report we show that submicromolar concentrations of dexamethasone enhance pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human hepatocytes.
J. Pascussi, L. Drocourt, Jean-Michel Fabre, P. Maurel, M. Vilarem   +4 more
semanticscholar   +1 more source