Results 181 to 190 of about 25,727 (222)
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Predictive Impact of Retinoid X Receptor-Alpha-Expression in Renal-Cell Carcinoma
Cancer Biotherapy and Radiopharmaceuticals, 2004Retinoid receptors are nuclear transcription factors that mediate the effects of retinoids on gene expression. In our study, we analyzed the expression of retinoid X receptor-alpha (RXR-alpha) and its prognostic value in renal-cell carcinoma (RCC) patients exhibiting stage IV disease upon first diagnosis or thereafter.Detection of RXR-alpha was ...
Stefan Stoerkel +5 more
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Structure-Based Design of Potent Retinoid X Receptor α Agonists
Journal of Medicinal Chemistry, 2004A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good potency against RXRalpha (K(i) = 6 nM) but was also found to be greater than 167-fold selective vs ...
Curt D. Haffner +13 more
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Science, 1993
The three-dimensional solution structure of the DNA binding domain (DBD) of the retinoid X receptor alpha (RXR alpha) was determined by nuclear magnetic resonance spectroscopy.
Min S. Lee +4 more
semanticscholar +1 more source
The three-dimensional solution structure of the DNA binding domain (DBD) of the retinoid X receptor alpha (RXR alpha) was determined by nuclear magnetic resonance spectroscopy.
Min S. Lee +4 more
semanticscholar +1 more source
Involvement of Retinoid X Receptor α in Coenzyme Q Metabolism
Journal of Molecular Biology, 2003The nuclear retinoid X receptor alpha (RXRalpha) is the heterodimer partner in several nuclear receptors, some of them regulating lipid biosynthesis. Since coenzyme Q (CoQ) levels are greatly modified in aging and a number of diseases, we have investigated the involvement of RXRalpha in the biosynthetic regulation of this lipid by using a hepatocyte ...
Mikael Turunen +4 more
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The Role of Retinoid X Receptor α in Regulating Alcohol Metabolism
The Journal of Pharmacology and Experimental Therapeutics, 2006There is substantial overlap in retinol and alcohol metabolism. Mice that lack retinoic acid (RA) receptor retinoid X receptor alpha (RXRalpha) expression in the liver are more susceptible to alcoholic liver disease. To investigate the interaction between RXRalpha and alcoholic liver disease, ethanol metabolism was studied in hepatocyte RXRalpha ...
Maxwell Afari Gyamfi +5 more
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Analysis of Vitamin D-receptor (VDR) and Retinoid X-receptor α in Breast Cancer
The Histochemical Journal, 2002The expression of vitamin D-receptor (VDR) and retinoid X-receptor alpha (RXR-alpha) has been analysed immunohistochemically in benign (n = 62 and n = 5 respectively) and malignant (n = 228 and n = 15 respectively) breast tissue samples using a monoclonal antibody 9A7gamma against VDR and a polyclonal antibody against RXR-alpha.
Jörg Reichrath +5 more
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Sequence requirements for high affinity retinoid X receptor-α homodimer binding
Molecular and Cellular Endocrinology, 1996To better delineate the sequence requirements for high affinity binding of retinoid X receptor alpha (RXR alpha) homodimers, a selection protocol was used starting from a random pool of oligonucleotides. All recovered sequences contained at least two hexamers related to the consensus sequence for the thyroid/retinoid subfamily of nuclear receptors, A ...
Ann Janssen +3 more
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Molecular Pharmacology, 2004
Retinoid X receptor alpha (RXRalpha) plays a pivotal role in regulating liver metabolism. RXRalpha-mediated gene expression involved in amino acid metabolism was examined using the NIA Mouse 15K cDNA microarray containing 15,000 different expressed ...
Yong Wu +10 more
semanticscholar +1 more source
Retinoid X receptor alpha (RXRalpha) plays a pivotal role in regulating liver metabolism. RXRalpha-mediated gene expression involved in amino acid metabolism was examined using the NIA Mouse 15K cDNA microarray containing 15,000 different expressed ...
Yong Wu +10 more
semanticscholar +1 more source
Biochemical Journal, 2001
The peroxisome-proliferator-activated receptor gamma (PPARgamma) is a member of the steroid/thyroid nuclear receptor superfamily of ligand-activated transcription factors.
M. Okuno +5 more
semanticscholar +1 more source
The peroxisome-proliferator-activated receptor gamma (PPARgamma) is a member of the steroid/thyroid nuclear receptor superfamily of ligand-activated transcription factors.
M. Okuno +5 more
semanticscholar +1 more source
Cancer Letters, 2003
RXRalpha is an obligatory heterodimerization partner in many signal transducing pathways. To evaluate RXRalpha expression during laryngeal carcinogenesis, immunohistochemistry was performed on laryngeal epithelial specimens of 154 patients with normal-appearing, hyperplastic, dysplastic laryngeal epithelium and squamous cell carcinoma.
Michalis V. Karamouzis +4 more
openaire +3 more sources
RXRalpha is an obligatory heterodimerization partner in many signal transducing pathways. To evaluate RXRalpha expression during laryngeal carcinogenesis, immunohistochemistry was performed on laryngeal epithelial specimens of 154 patients with normal-appearing, hyperplastic, dysplastic laryngeal epithelium and squamous cell carcinoma.
Michalis V. Karamouzis +4 more
openaire +3 more sources