Results 11 to 20 of about 25,727 (222)

20(S)-Protopanaxadiol inhibits epithelial-mesenchymal transition by promoting retinoid X receptor alpha in human colorectal carcinoma cells. [PDF]

J Cell Mol Med, 2020
Colorectal carcinoma (CRC) recurrence is often accompanied by metastasis. Most metastasis undergo through epithelial‐mesenchymal transition (EMT). Studies showed that retinol X receptor alpha (RXRα) and 20(S)‐Protopanaxadiol (PPD) have anti‐tumour ...
Lu Z, Liu H, Fu W, Wang Y, Geng J, Wang Y, Yu X, Wang Q, Xu H, Sui D.   +9 more
europepmc   +4 more sources

The Prognostic Impact of Retinoid X Receptor and Thyroid Hormone Receptor alpha in Unifocal vs. Multifocal/Multicentric Breast Cancer [PDF]

International Journal of Molecular Sciences, 2021
The aim of this study was to assess the prognostic value of the steroid hormone receptor expression, counting the retinoid X receptor (RXR) and thyroid hormone receptors (THRs), on the two different breast cancer (BC) entities: multifocal/multicentric ...
Alaleh Zati zehni, Falk Batz, Aurelia Vattai, Till Kaltofen, Svenja Schrader, Sven Jacob, Jan‐Niclas Mumm, Helene Hildegard Heidegger, Nina Ditsch, Sven Mahner, Udo Jeschke, Theresa� Vilsmaier   +11 more
semanticscholar   +7 more sources

CALR but Not JAK2 Mutations Are Associated with an Overexpression of Retinoid X Receptor Alpha in Essential Thrombocythemia. [PDF]

Cancers (Basel)
Essential thrombocythemia (ET) is a blood cancer caused by mutations in JAK2 and CALR. It is widely recognized that both mutations lead to the constitutive activation of JAK2/STAT signaling, although other JAK/STAT-independent pathogenic mechanisms triggered by these alterations have also been described in ET.
Guijarro-Hernández A, Hurtado C, Larráyoz MJ, Calasanz MJ, Vizmanos JL.   +4 more
europepmc   +5 more sources

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice. [PDF]

Proceedings of the National Academy of Sciences, 1995
We have recently characterized a cardiac model of ventricular chamber defects in retinoid X receptor alpha (RXR alpha) homozygous mutant (-/-) gene-targeted mice.
E. D. Dyson, Henry M. Sucov, S. Kubalak, Geert W. Schmid‐Schönbein, F. A. DeLano, Ronald M. Evans, John Ross, Kenneth R. Chien   +7 more
semanticscholar   +5 more sources

Retinoid X receptor alpha forms tetramers in solution. [PDF]

Proceedings of the National Academy of Sciences, 1995
Protein-protein interactions allow the retinoid X receptor (RXR) to bind to cognate DNA as a homo- or a heterodimer and to participate in mediating the effects of a variety of hormones on gene transcription.
Sander Kersten, Kelleher Dk, Pierre Chambon, Hinrich Gronemeyer, Noa Noy   +4 more
semanticscholar   +6 more sources

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha

Biomedicine & Pharmacotherapy, 2023
Retinoid X receptor alpha (RXRα) is a nuclear transcription factor that extensively regulates energy metabolism in cardiovascular diseases. Identification of targeted RXRα drugs for heart failure (HF) therapy is urgently needed. Neocryptotanshinone (NCTS) is a component derived from Salvia miltiorrhiza Bunge, the effect and mechanism of which for ...
Lin Ma, Mingyan Shao, Wenkun Cheng, Jinchi Jiang, Xu Chen, Nannan Tan, Guanjing Ling, Ye Yang, Qian Wang, Ran Yang, Chun Li, Yong Wang   +11 more
semanticscholar   +4 more sources

The effect of antagonists on the conformational exchange of the retinoid X receptor alpha ligand-binding domain. [PDF]

Magn Reson Chem, 2009
AbstractThe effect of retinoid X receptor (RXR) antagonists on the conformational exchange of the RXR ligand‐binding domain (LBD) remains poorly characterized. To address this question, we used nuclear magnetic resonance spectroscopy to compare the chemical shift perturbations induced by RXR antagonists and agonists on the RXRα LBD when partnered with ...
Lu J, Dawson MI, Hu QY, Xia Z, Dambacher JD, Ye M, Zhang XK, Li E.   +7 more
europepmc   +6 more sources

Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures. [PDF]

J Virol, 2018
Song M, Sun Y, Tian J, He W, Xu G, Jing Z, Li W.   +6 more
europepmc   +3 more sources

Transcriptional control of nucleus accumbens neuronal excitability by Retinoid X Receptor Alpha tunes sensitivity to drug rewards [PDF]

Neuron, 2022
The complex nature of the transcriptional networks underlying addictive behaviors suggests intricate cooperation between diverse gene regulation mechanisms that go beyond canonical activity-dependent pathways.
Arthur Godino, Marine Salery, Romain Durand-de Cuttoli, Molly Estill, Leanne M. Holt, Rita Futamura, Caleb J. Browne, Philipp Mews, Peter J. Hamilton, Rachael L. Neve, Li Shen, Scott J. Russo, Eric J. Nestler   +12 more
openalex   +2 more sources

Single nucleotide polymorphisms of RXRA encoding retinoid X receptor alpha [PDF]

Journal of Human Genetics, 2001
Retinoic X receptor alpha (RXRA), encoded by RXRA, plays a key role in development and metabolism, specifically in adipocyte biology, glucose homeostasis, and intestinal cholesterol balance. RXRA is also a positional candidate gene for Berardinelli-Seip congenital lipodystrophy.
R A Hegele, H. Cao
openalex   +4 more sources