Results 11 to 20 of about 14,401 (197)

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. [PDF]

Nucleic Acids Res, 2012
Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes. Studies using Nrf2-deficient mice suggest that hundreds of genes may be regulated by NRF2.
Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR, Bell DA.   +9 more
europepmc   +5 more sources

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. [PDF]

Sci Adv, 2020
RXRA is an endothelial- and early stage–predominant therapeutic target for treating anthracycline-induced cardiotoxicity.
Ma X, Zhu P, Ding Y, Zhang H, Qiu Q, Dvornikov AV, Wang Z, Kim M, Wang Y, Lowerison M, Yu Y, Norton N, Herrmann J, Ekker SC, Hsiai TK, Lin X, Xu X.   +16 more
europepmc   +5 more sources

Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures. [PDF]

J Virol, 2018
ABSTRACT Multiple steps of the life cycle of hepatitis B virus (HBV) are known to be coupled to hepatic metabolism. However, the details of involvement of the hepatic metabolic milieu in HBV infection remain incompletely understood.
Song M, Sun Y, Tian J, He W, Xu G, Jing Z, Li W.   +6 more
europepmc   +5 more sources

The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis. [PDF]

Dig Dis Sci, 2014
In order for vitamin D to signal and regulate inflammatory pathways, it must bind to its receptor (VDR) which must heterodimerize with the retinoid X receptor alpha (RXRα). Although the role that vitamin D signaling plays in the development and progression of colitis, a disease characterized by excessive inflammation, has been suggested, little ...
Knackstedt R, Shaoli S, Moseley V, Wargovich M.   +3 more
europepmc   +5 more sources

Abstract 1912: Retinoid x Receptor Alpha DNA Binding for Mitochondrial Transcription

Journal of Biological Chemistry, 2023
James Weiser, Megan Bestwick
openalex   +2 more sources

Single nucleotide polymorphisms of RXRA encoding retinoid X receptor alpha [PDF]

Journal of Human Genetics, 2001
Retinoic X receptor alpha (RXRA), encoded by RXRA, plays a key role in development and metabolism, specifically in adipocyte biology, glucose homeostasis, and intestinal cholesterol balance. RXRA is also a positional candidate gene for Berardinelli-Seip congenital lipodystrophy.
R A Hegele, H. Cao
openalex   +3 more sources

CALR but Not JAK2 Mutations Are Associated with an Overexpression of Retinoid X Receptor Alpha in Essential Thrombocythemia. [PDF]

Cancers (Basel)
Guijarro-Hernández A, Hurtado C, Larráyoz MJ, Calasanz MJ, Vizmanos JL.   +4 more
europepmc   +3 more sources

20(S)-Protopanaxadiol inhibits epithelial-mesenchymal transition by promoting retinoid X receptor alpha in human colorectal carcinoma cells. [PDF]

J Cell Mol Med, 2020
Lu Z, Liu H, Fu W, Wang Y, Geng J, Wang Y, Yu X, Wang Q, Xu H, Sui D.   +9 more
europepmc   +3 more sources

Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy [PDF]

Cells
This study investigated the therapeutic potential of the nuclear retinoid X receptor (RXR) in mitigating the progression of alpha-synucleinopathies (αSNPs), particularly in Parkinson’s disease (PD).
Assylbek Zhylkibayev, Christopher R. Starr, M. Iqbal Hossain, Sandeep Kumar, Shaida A. Andrabi, Maria B. Grant, Venkatram R. Atigadda, Marina S. Gorbatyuk, Oleg S. Gorbatyuk   +8 more
doaj   +2 more sources

Publisher Correction: Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function. [PDF]

Sci Rep, 2020
Saxena V, Fitch J, Ketz J, White P, Wetzel A, Chanley MA, Spencer JD, Becknell B, Pierce KR, Arregui SW, Nelson RD, Schwartz GJ, Velazquez V, Walker LA, Chen X, Yan P, Hains DS, Schwaderer AL.   +17 more
europepmc   +3 more sources