Results 191 to 200 of about 25,727 (222)
Some of the next articles are maybe not open access.
Endocrinology, 2003
Hepatocyte retinoid X receptor (RXR)alpha-deficient mice and wild-type mice were fed either a regular or a high-saturated-fat diet for 12 wk to study the functional role of hepatocyte RXRalpha in fatty acid and carbohydrate metabolism.
Y. Wan +5 more
semanticscholar +1 more source
Hepatocyte retinoid X receptor (RXR)alpha-deficient mice and wild-type mice were fed either a regular or a high-saturated-fat diet for 12 wk to study the functional role of hepatocyte RXRalpha in fatty acid and carbohydrate metabolism.
Y. Wan +5 more
semanticscholar +1 more source
Rapid Communications in Mass Spectrometry, 2001
The vitamin D receptor (VDR) binds zinc, and the activity of vitamin D dependent genes in cells is influenced by intracellular zinc concentrations. To determine whether zinc influences vitamin D action in cells by modulating the formation of VDR and ...
T. Craig +3 more
semanticscholar +1 more source
The vitamin D receptor (VDR) binds zinc, and the activity of vitamin D dependent genes in cells is influenced by intracellular zinc concentrations. To determine whether zinc influences vitamin D action in cells by modulating the formation of VDR and ...
T. Craig +3 more
semanticscholar +1 more source
Endocrinology, 1995
The regulation of gene expression by retinoids is mediated by two classes of receptors, retinoic acid receptors and retinoid X receptors (RXR). RXR can bind to specific target genes as homodimers, and these homodimers can activate gene expression in the presence of the ligand 9-cis-retinoic acid. A direct repeat of AGGTCA with a 1 base pair spacer (DR1)
Ronald J. Koenig +2 more
openaire +3 more sources
The regulation of gene expression by retinoids is mediated by two classes of receptors, retinoic acid receptors and retinoid X receptors (RXR). RXR can bind to specific target genes as homodimers, and these homodimers can activate gene expression in the presence of the ligand 9-cis-retinoic acid. A direct repeat of AGGTCA with a 1 base pair spacer (DR1)
Ronald J. Koenig +2 more
openaire +3 more sources
Immunohistochemical Detection of the Retinoid × Receptors α, β, and γ in Human Prostate
Journal of Andrology, 2003ABSTRACT: The aim of this study was to evaluate the presence and distribution of retinoid × receptors (RXRs) α, β, and γ in normal, hyperplastic (nodular, basal cell, and atrophic hyperplasia), and carcinomatous human prostates in order to elucidate the relationship among these receptors and the onset and development of prostatic adenocarcinoma.
Ricardo Paniagua +5 more
openaire +3 more sources
The Histochemical Journal, 1997
Increasing evidence suggests that the retinoid-X receptors (RXR-alpha,-beta,-gamma) play a crucial role in regulating the transcriptional activity of several steroid hormone receptors, including the receptors for retinoic acid (RAR-alpha,-beta,-gamma), 1,25-dihydroxyvitamin D3 and thyroid hormone. We investigated the localization of the different types
Jörg Reichrath +3 more
openaire +3 more sources
Increasing evidence suggests that the retinoid-X receptors (RXR-alpha,-beta,-gamma) play a crucial role in regulating the transcriptional activity of several steroid hormone receptors, including the receptors for retinoic acid (RAR-alpha,-beta,-gamma), 1,25-dihydroxyvitamin D3 and thyroid hormone. We investigated the localization of the different types
Jörg Reichrath +3 more
openaire +3 more sources
Expression of Retinoid X Receptor α Is Increased upon Monocytic Cell Differentiation
Biochemical and Biophysical Research Communications, 19961 alpha, 25-Dihydroxyvitamin D3 (VD) is a potent inducer of monocytic differentiation of both normal and leukemic cells. Its effects are mediated by its nuclear receptor (VDR). Efficient gene activation requires the heterodimerization of VDR with Retinoid X Receptors (RXR).
H. Defacque +6 more
openaire +3 more sources
Cancer Research, 2017
Abstract Inflammatory bowel disease (IBD), encompassing both ulcerative colitis and Crohn's disease, is a high risk factor for colorectal cancer (CRC). It is a lifelong inflammation-driven disorder with a poorly defined etiology contributing to limitations in available treatment options.
Jay Morris +2 more
openaire +2 more sources
Abstract Inflammatory bowel disease (IBD), encompassing both ulcerative colitis and Crohn's disease, is a high risk factor for colorectal cancer (CRC). It is a lifelong inflammation-driven disorder with a poorly defined etiology contributing to limitations in available treatment options.
Jay Morris +2 more
openaire +2 more sources
Mechanisms of Ageing and Development, 2002
Aging is associated with alterations in hepatic peroxisomal metabolism and susceptibility to hepatocarcinogenicity produced by agonists of peroxisome proliferator-activated receptor alpha (PPAR alpha). Mechanisms involved in these effects are not well understood. However, as a heterodimer with retinoid X receptor alpha (RXR alpha), PPAR alpha regulates
Mostafa Z. Badr +4 more
openaire +3 more sources
Aging is associated with alterations in hepatic peroxisomal metabolism and susceptibility to hepatocarcinogenicity produced by agonists of peroxisome proliferator-activated receptor alpha (PPAR alpha). Mechanisms involved in these effects are not well understood. However, as a heterodimer with retinoid X receptor alpha (RXR alpha), PPAR alpha regulates
Mostafa Z. Badr +4 more
openaire +3 more sources
Journal of Molecular Graphics and Modelling, 2008
The family of peroxisome proliferator-activated receptors (PPARs) is the molecular target of synthetic antidiabetic and hypolipidemic drugs. The side effects of these drugs are limiting their use in patients with high lipid levels. Natural compounds, like Docosahexaenoic acid (DHA) from fish oil, have beneficial effects in the treatment of metabolic ...
Osman A. B. S. M. Gani, Ingebrigt Sylte
openaire +3 more sources
The family of peroxisome proliferator-activated receptors (PPARs) is the molecular target of synthetic antidiabetic and hypolipidemic drugs. The side effects of these drugs are limiting their use in patients with high lipid levels. Natural compounds, like Docosahexaenoic acid (DHA) from fish oil, have beneficial effects in the treatment of metabolic ...
Osman A. B. S. M. Gani, Ingebrigt Sylte
openaire +3 more sources