Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function. [PDF]
Sci Rep, 2019 The renal collecting duct consists of intercalated cells (ICs) and principal cells (PCs). We have previously demonstrated that collecting ducts have a role in the innate immune defense of the kidney.
Saxena V +17 more
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Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.
Journal of Biological Chemistry, 1994 Ligand-induced structural alterations of retinoid X receptor (RXR) appear to facilitate receptor homodimerization, to enhance DNA binding of RXR homodimeric complexes, and to dictate the transcriptional activation properties of RXR complexes bound to response elements located in the promoter region of 9-cis-retinoic acid responsive genes. The technique
Mark Leid
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Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X Receptor Alpha [PDF]
PPAR Research, 2006 It has been proposed that PPAR-dependent, accelerated catabolism of proinflammatory mediators may contribute to the fast resolution of inflammation. Because retinoid X receptors are obligate heterodimer partners of PPARs, we investigated the impact of ...
Yu-Jui Yvonne Wan, Mostafa Z. Badr
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Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes. [PDF]
Molecular Endocrinology, 1996 The 1 alpha,25-dihydroxyvitamin D3 (VD3)-dependent stimulation of osteocalcin (OC) and osteopontin (OP) gene transcription in bone tissue is mediated by interactions of trans-activating factors with distinct VD3-responsive elements (VDREs).
Ada Staal +10 more
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Hypericum sampsonii induces apoptosis and nuclear export of retinoid X receptor-alpha [PDF]
Carcinogenesis, 2006 Natural products derived from plants provide a rich source for development of new anticancer drugs. Recent studies suggest that modulation of subcellular localization of retinoid X receptor-alpha (RXRalpha) represents a potential approach for inducing cancer cell apoptosis.
Jiao Zeng
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Distinct functional modes of SUMOylation for retinoid X receptor alpha [PDF]
Biochemical and Biophysical Research Communications, 2015 The present study investigated human retinoid X receptor alpha (hRXRα) as a substrate for modification with small ubiquitin like modifier (SUMO) and how members of the protein inhibitor of activated STAT (PIAS) family may impact upon this process. In agreement with a previous study, we validate Ubc9 to facilitate SUMOylation of hRXRα at lysine 108 but ...
Wai-Ping Lee +6 more
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Transcriptional control of nucleus accumbens neuronal excitability by retinoid X receptor alpha tunes sensitivity to drug rewards. [PDF]
Neuron, 2023 Godino A +12 more
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Retinoid X receptor RXR alpha binds to and trans-activates the hepatitis B virus enhancer. [PDF]
Proceedings of the National Academy of Sciences, 1992 A retinoid X receptor (RXR) response element was located within the functionally defined hepatitis B virus (HBV) enhancer element. A short segment of the enhancer that contains this region has been shown with genetic analysis to play a key role in the regulation of enhancer function and to represent a major determinant of liver-specific activity.
Bingfang Huan, Aleem Siddiqui
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Improvement of Skin Condition Through RXR Alpha-Activating Materials [PDF]
BiomoleculesRetinol is well-known anti-aging material in the cosmetics industry, owing to its proven superior efficacy both in vitro and in vivo. Despite its high efficacy, retinol is associated with limitations, such as skin irritation and its potential ...
Sanghyun Ye +4 more
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Date palm seed extract and herbal mixture mitigate gentamicin-induced renal injury in mice: Role of Protease-activated receptors (PARs) and Retinoid X receptor alpha (RXR-α) [PDF]
Journal of HerbMed Pharmacology, 2022 Introduction: Gentamicin (Gen) causes renal toxicity by inhibiting protein synthesis in kidney cells, causing proximal tubule cell necrosis and renal failure. Herein, we examined the nephroprotective effect of date palm seed extract (DPSE) and one herbal
Suliman Sohaim +4 more
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