Results 31 to 40 of about 14,401 (197)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha

Biomedicine & Pharmacotherapy, 2023
Retinoid X receptor alpha (RXRα) is a nuclear transcription factor that extensively regulates energy metabolism in cardiovascular diseases. Identification of targeted RXRα drugs for heart failure (HF) therapy is urgently needed. Neocryptotanshinone (NCTS) is a component derived from Salvia miltiorrhiza Bunge, the effect and mechanism of which for ...
Lin Ma, Mingyan Shao, Wenkun Cheng, Jinchi Jiang, Xu Chen, Nannan Tan, Guanjing Ling, Ye Yang, Qian Wang, Ran Yang, Chun Li, Yong Wang   +11 more
openalex   +3 more sources

Molecular basis of ligand-dependent Nurr1-RXRα activation

eLife, 2023
Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha (RXRα) (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechanisms ...
Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin   +2 more
doaj   +1 more source

Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis. [PDF]

PLoS ONE, 2011
BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals.
Ouxi Shen, Wei Wu, Guizhen Du, Renping Liu, Lugang Yu, Hong Sun, Xiumei Han, Yi Jiang, Wei Shi, Wei Hu, Ling Song, Yankai Xia, Shoulin Wang, Xinru Wang   +13 more
doaj   +1 more source

P050 Paneth cell retinoid X receptor alpha drives metabolic gut inflammation [PDF]

Journal of Crohn's and Colitis
Abstract Background The rising incidence of inflammatory bowel diseases throughout the western world could be partially explained by changes in dietary behaviour such as an increased consumption of polyunsaturated fatty acids (PUFA).
Markus Meyer, Felix Grabherr, Christina Plattner, Dietmar Rieder, V. Marteau, Julian Schwärzler, Lisa Mayr, Barbara Enrich, Richard Hilbe, Almina Jukic, Christoph Grander, Andreas Zollner, Zlatko Trajanoski, Herbert Tilg, Timon E. Adolph   +14 more
openalex   +2 more sources

Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells

Cells, 2023
Okadaic acid (OA) is a marine biotoxin that is produced by algae and accumulates in filter-feeding shellfish, through which it enters the human food chain, leading to diarrheic shellfish poisoning (DSP) after ingestion. Furthermore, additional effects of
Leonie T. D. Wuerger, Felicia Kudiabor, Jimmy Alarcan, Markus Templin, Oliver Poetz, Holger Sieg, Albert Braeuning   +6 more
doaj   +1 more source

Retinoid X receptor alpha (RXRα) interaction with sugars

The FASEB Journal, 2013
Nuclear receptors, peroxisome proliferator‐activated receptor alpha (PPARα) and liver X receptor alpha (LXRα), with their heterodimeric partner, RXRα, regulate transcriptional activity of lipid and glucose metabolism. It has been shown that glucose binds with high affinity to PPARα, and that transcriptional activity induced by the PPARα‐RXRα ...
Frances L Soman, Camila de Jesus Piva, Heather A. Hostetler   +2 more
openaire   +1 more source

Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid

Reproductive Biology and Endocrinology, 2003
Retinoids, a class of compounds that include retinol and its metabolite, retinoic acid, are absolutely essential for ovarian steroid production, oocyte maturation, and early embryogenesis.
Malayer Jerry, Thirumalapura Nagaraja, Mohan Mahesh   +2 more
doaj   +1 more source

Involvement of transcription factor NR2F2 in human trophoblast differentiation. [PDF]

PLoS ONE, 2010
During the in vitro differentiation of human villous cytotrophoblast (CTB) cells to a syncytiotrophoblast (STB) phenotype, mRNA levels for the nuclear hormone receptor NR2F2 (ARP-1, COUP-TFII) increase rapidly, reaching a peak at day 1 of differentiation
Michael A Hubert, Susan L Sherritt, Cindy J Bachurski, Stuart Handwerger   +3 more
doaj   +1 more source

Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cholestasis is the major cause of the accumulation of bile acids and results in liver damage, fibrosis, and failure. A growing number of studies have shown that gentiopicroside is a promising prospect that may protect the liver. However,
Han Han, Lili Xu, Kai Xiong, Tong  Zhang, Zhengtao Wang   +4 more
doaj   +1 more source