Results 31 to 40 of about 25,727 (222)

Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells [PDF]

Journal of Molecular Endocrinology, 2004
Retinoic acid receptor alpha (RARalpha) plays an important role in mediating all-trans retinoic acid (ATRA) signals. In this study, we found that ATRA up-regulated RARalpha mRNA and protein expression in gastric cancer BGC-823 cells. However, in breast cancer MCF-7 cells it down-regulated RARalpha protein expression with no effect on its RARalpha mRNA.
Qiyuan Wu, Xiaohe Lin, X.M. Ye, Bing Zhang, Zhihua Xie, Wang Su   +5 more
openalex   +5 more sources

DNA binding specificity and function of retinoid X receptor alpha.

Journal of Biological Chemistry, 1994
Retinoid X receptors are members of the erbA superfamily of ligand-inducible transcription factors. Similar to several other members of this gene family, retinoid X receptors are known to bind to the hexameric DNA sequence AGGTCA. After binding to a direct repeat of this hexamer with a one-base pair spacer, retinoid X receptor homodimers are able to ...
José S. Subauste, Ronald W. Katz, Ronald J. Koenig   +2 more
openalex   +4 more sources

Retinoid X Receptor as a Therapeutic Target to Treat Neurological Disorders Associated with α-Synucleinopathy [PDF]

Cells
This study investigated the therapeutic potential of the nuclear retinoid X receptor (RXR) in mitigating the progression of alpha-synucleinopathies (αSNPs), particularly in Parkinson’s disease (PD).
Assylbek Zhylkibayev, Christopher R. Starr, M. Iqbal Hossain, Sandeep Kumar, Shaida A. Andrabi, Maria B. Grant, Venkatram R. Atigadda, Marina S. Gorbatyuk, Oleg S. Gorbatyuk   +8 more
doaj   +2 more sources

Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity. [PDF]

Molecular Endocrinology, 1993
Overexpression of the multifunctional growth factor transforming growth factor-beta 1 (TGF beta 1) has been connected to numerous diseases in human. TGF beta 1 expression is largely governed by three AP-1 binding sites located in two different promoters ...
Gilles Salbert, Andrea Fanjul, F. Javier Piedrafita, Xingang Lu, Sun Ju Kim, P Tran, Magnus Pfahl   +6 more
openalex   +2 more sources

Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro. [PDF]

PLoS ONE
PurposeIn the present study, we evaluate gene and protein expression levels in an in vitro siRNA-mediated PAX6 knockdown limbal epithelial cell (LEC) model after RA treatment.
Shao-Lun Hsu, Tanja Stachon, Fabian N Fries, Zhen Li, Shuailin Li, Shanhe Liu, Berthold Seitz, Swarnali Kundu, Maryam Amini, Shweta Suiwal, Nóra Szentmáry   +10 more
doaj   +2 more sources

Characterization of the ligand binding domain of human retinoid X receptor alpha expressed in Escherichia coli

Journal of Biological Chemistry, 1994
In order to study the structural details of ligand protein interactions of the human retinoid X receptor alpha (hRXR alpha), the DEF and EF domains of the receptor were expressed as glutathione S-transferase (GST) fusion proteins in Escherichia coli.
Lin Cheng, Andrew W. Norris, Bonnie F. Tate, M. Rosenberger, Joseph F. Grippo, E Li   +5 more
openalex   +4 more sources

Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes [PDF]

Journal of Molecular Endocrinology, 1999
We have previously demonstrated that dexamethasone (DEX) enhances the T3-dependent increase in type I 5'-deiodinase (5'DI) mRNA in primary cultured rat hepatocytes grown as spheroids.
Soichi YAMAGUCHI, Yoji Murata, Takashi Nagaya, Yoshitaka Hayashi, Sachiko Ohmori, Y Nimura, Hisao Seo   +6 more
openalex   +2 more sources

Publisher Correction: Whole Transcriptome Analysis of Renal Intercalated Cells Predicts Lipopolysaccharide Mediated Inhibition of Retinoid X Receptor alpha Function. [PDF]

Sci Rep, 2020
Saxena V, Fitch J, Ketz J, White P, Wetzel A, Chanley MA, Spencer JD, Becknell B, Pierce KR, Arregui SW, Nelson RD, Schwartz GJ, Velazquez V, Walker LA, Chen X, Yan P, Hains DS, Schwaderer AL.   +17 more
europepmc   +3 more sources

Effects of allicin on human Simpson-Golabi-Behmel syndrome cells in mediating browning phenotype

Frontiers in Endocrinology, 2023
IntroductionObesity is a major health problem because it is associated with increased risk of cardiovascular disease, diabetes, hypertension, and some cancers.
Uzair Ali, Martin Wabitsch, Daniel Tews, Monica Colitti   +3 more
doaj   +1 more source

FOXA1 reprogramming dictates retinoid X receptor response in ESR1 mutant breast cancer.

Molecular Cancer Research, 2023
Estrogen receptor alpha (ER/ESR1) mutations occur in 30-40% of endocrine resistant ER-positive (ER+) breast cancer. Forkhead Box A1 (FOXA1) is a key pioneer factor mediating ER-chromatin interactions and endocrine response in ER+ breast cancer, but its ...
Yang Wu, Zheqi Li, Abdalla M. Wedn, Allison N Casey, Daniel D Brown, Shalini V Rao, Soleilmane Omarjee, J. Hooda, J. Carroll, Jason Gertz, J. Atkinson, Adrian V. Lee, S. Oesterreich   +12 more
semanticscholar   +1 more source