Results 41 to 50 of about 14,401 (197)
Nature Communications, 2019 The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in ...
Xiaohong Ye +8 more
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Nature Communications, 2017 The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its ...
Liqun Chen +22 more
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Orphan Receptor TR3 Attenuates the p300-Induced Acetylation of Retinoid X Receptor-α [PDF]
Molecular Endocrinology, 2007 AbstractAcetylation modification regulates the functions of histone and nonhistone proteins, including transcriptional activity, protein interaction, and subcellular localization. Although many nuclear receptors have been shown to be modified by acetylation, whether retinoid X receptors (RXRs) are acetylated and how the acetylation is regulated remains
Zhao, Wen-xiu +7 more
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Molecules, 2019 We recently established a KAIMRC1 cell line that has unique features compared to the known breast cancer cell lines, MCF7 and MDA-MB231. To characterize it further, we investigated the expression profile of nuclear receptors and their respective co ...
Atef Nehdi +11 more
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The Prognostic Impact of Retinoid X Receptor and Thyroid Hormone Receptor alpha in Unifocal vs. Multifocal/Multicentric Breast Cancer [PDF]
International Journal of Molecular Sciences, 2021 The aim of this study was to assess the prognostic value of the steroid hormone receptor expression, counting the retinoid X receptor (RXR) and thyroid hormone receptors (THRs), on the two different breast cancer (BC) entities: multifocal/multicentric versus unifocal.
Alaleh Zati Zehni +11 more
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Marine Drugs, 2019 Five new ergostanes, penicisteroids D−H (1−5), were isolated from the liquid culture of the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, along with 27 known compounds. The structures of the new steroids were established mainly
Chun-Lan Xie +11 more
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Frontiers in Pharmacology, 2021 Yiqi Fumai lyophilized injection (YQFM) is the recombination of Sheng mai san (SMS).YQFM has been applied clinically to efficaciously and safely treat chronic heart failure (CHF). However, the mechanism of YQFM is still not fully elucidated.
Xiaoying Han +11 more
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Chemoproteomic profiling reveals cellular targets of nitro-fatty acids
Redox Biology, 2021 Nitro-fatty acids are a class of endogenous electrophilic lipid mediators with anti-inflammatory and cytoprotective effects in a wide range of inflammatory and fibrotic disease models.
Ming-Yu Fang +8 more
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Phosphorylated retinoid X receptor α loses its heterodimeric activity with retinoic acid receptor β [PDF]
Cancer Science, 2007 A malfunction in retinoid X receptor (RXR) α due to phosphorylation is associated with the development of hepatocellular carcinoma. However, the precise mechanisms by which phosphorylated RXRα loses its physiological function remain unclear. In the present study we examined whether phosphorylation of RXRα affects its dimeric activity.
Kotaro, Yoshimura +9 more
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Serum Proteomic Analysis of Cannabis Use Disorder in Male Patients
Molecules, 2021 Cannabis use has been growing recently and it is legally consumed in many countries. Cannabis has a variety of phytochemicals including cannabinoids, which might impair the peripheral systems responses affecting inflammatory and immunological pathways ...
Fawaz Alasmari +9 more
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