Results 41 to 50 of about 25,727 (222)
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
A Structure-based Approach to Retinoid X Receptor-α Inhibition [PDF]
Journal of Biological Chemistry, 2006 In this paper we describe a structure-based approach designed to identify novel ligands for retinoid X receptor-alpha (RXRalpha). By using a virtual approach based on a modified scoring function, we have selected 200 potential candidates on the basis of their predicted ability of docking into the ligand-binding site of the target.
Stebbins JL +4 more
openaire +3 more sources
Molecular basis of ligand-dependent Nurr1-RXRα activation
eLife, 2023 Small molecule compounds that activate transcription of Nurr1-retinoid X receptor alpha (RXRα) (NR4A2-NR2B1) nuclear receptor heterodimers are implicated in the treatment of neurodegenerative disorders, but function through poorly understood mechanisms ...
Xiaoyu Yu +2 more
doaj +1 more source
Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis. [PDF]
PLoS ONE, 2011 BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals.
Ouxi Shen +13 more
doaj +1 more source
Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells
Cells, 2023 Okadaic acid (OA) is a marine biotoxin that is produced by algae and accumulates in filter-feeding shellfish, through which it enters the human food chain, leading to diarrheic shellfish poisoning (DSP) after ingestion. Furthermore, additional effects of
Leonie T. D. Wuerger +6 more
doaj +1 more source
Orphan Receptor TR3 Attenuates the p300-Induced Acetylation of Retinoid X Receptor-α [PDF]
Molecular Endocrinology, 2007 AbstractAcetylation modification regulates the functions of histone and nonhistone proteins, including transcriptional activity, protein interaction, and subcellular localization. Although many nuclear receptors have been shown to be modified by acetylation, whether retinoid X receptors (RXRs) are acetylated and how the acetylation is regulated remains
Zhao, Wen-xiu +7 more
openaire +4 more sources
Involvement of transcription factor NR2F2 in human trophoblast differentiation. [PDF]
PLoS ONE, 2010 During the in vitro differentiation of human villous cytotrophoblast (CTB) cells to a syncytiotrophoblast (STB) phenotype, mRNA levels for the nuclear hormone receptor NR2F2 (ARP-1, COUP-TFII) increase rapidly, reaching a peak at day 1 of differentiation
Michael A Hubert +3 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2003 Retinoids, a class of compounds that include retinol and its metabolite, retinoic acid, are absolutely essential for ovarian steroid production, oocyte maturation, and early embryogenesis.
Malayer Jerry +2 more
doaj +1 more source
Retinoid X receptor alpha (RXRα) interaction with sugars
The FASEB Journal, 2013 Nuclear receptors, peroxisome proliferator‐activated receptor alpha (PPARα) and liver X receptor alpha (LXRα), with their heterodimeric partner, RXRα, regulate transcriptional activity of lipid and glucose metabolism. It has been shown that glucose binds with high affinity to PPARα, and that transcriptional activity induced by the PPARα‐RXRα ...
Frances L. Soman +2 more
openaire +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Cholestasis is the major cause of the accumulation of bile acids and results in liver damage, fibrosis, and failure. A growing number of studies have shown that gentiopicroside is a promising prospect that may protect the liver. However,
Han Han +4 more
doaj +1 more source