Results 51 to 60 of about 14,401 (197)

In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer

Molecular Cancer, 2006
Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an agonist of the retinoid-X-receptor.
Charnock-Jones D Stephen, Holland Cathrine M, Saidi Samir A, Smith Stephen K   +3 more
doaj   +1 more source

Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha

BMC Cancer, 2008
Background The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the participation of retinoid X receptors
Fraile Benito, Alba Emilio, González Francisco J, Pérez Julio, Zamora Javier, Lobo María VT, Conde Isabel, Paniagua Ricardo, Arenas María I   +8 more
doaj   +1 more source

Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease

Hepatology Communications, 2018
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adults. This study examined the relationship between hepatic nuclear receptor (NR) expression and histologic features of NAFLD.
Erin E. Elbel, Joel E. Lavine, Michael Downes, Mark Van Natta, Ruth Yu, Jeffrey B. Schwimmer, Cynthia Behling, Elizabeth M. Brunt, James Tonascia, Ronald Evans   +9 more
doaj   +1 more source

Peroxisome proliferator‐activated receptor α–retinoid X receptor agonists induce beta‐cell protection against palmitate toxicity [PDF]

The FEBS Journal, 2007
Fatty acids can stimulate the secretory activity of insulin‐producing beta‐cells. At elevated concentrations, they can also be toxic to isolated beta‐cells. This toxicity varies inversely with the cellular ability to accumulate neutral lipids in the cytoplasm. To further examine whether cytoprotection can be achieved by decreasing cytoplasmic levels of
Hellemans, Karine, Kerckhofs, Karen, Hannaert, Jean, Martens, Geert, Van Veldhoven, Paul, Pipeleers, Daniel   +5 more
openaire   +3 more sources

Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes [PDF]

FEBS Letters, 1997
A novel potential regulatory pathway of brown adipose tissue (BAT) thermogenesis was recently recognized after identifying retinoic acid (RA) as a transcriptional activator of the uncoupling protein (UCP) gene. Here we provide evidence that the UCP responsiveness to RA in primary cultures of brown adipocytes involves RA receptor α (RARα), and show, in ...
Bonet, M.Luisa, Puigserver, Pere, Serra, Francisca, Ribot, Joan, Vázquez, Francisca, Picó, Catalina, Palou, Andreu   +6 more
openaire   +2 more sources

ABCA1-Super Enhancer RNA Promotes Cholesterol Efflux, Reduces Macrophage-Mediated Inflammation and Atherosclerosis

JACC: Basic to Translational Science
Summary: We describe a previously uncharacterized ATP-binding cassette A1 super enhancer RNA (ABCA1-seRNA)-mediated cholesterol efflux. In addition, it promoted macrophage inflammatory cytokine release, and was causally correlated with coronary artery ...
Jing Wang, PhD, Qianqian Xiao, MD, Yuwei Cai, MD, Man Wang, MD, Chen Chen, MD, Luyun Wang, MD, PhD, Ruiying Ma, MD, Yanyan Cao, PhD, Yan Wang, MD, PhD, Hu Ding, MD, PhD, Dao Wen Wang, MD, PhD   +10 more
doaj   +1 more source

Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish

Nature Communications, 2023
Nonsteroidal anti-inflammatory drugs compose one of the most widely used classes of medications, but the risks for early development remain controversial, especially in the nervous system.
Wenwei Sun, Meimei Wang, Jun Zhao, Shuang Zhao, Wenchao Zhu, Xiaoting Wu, Feifei Li, Wei Liu, Zhuo Wang, Meng Gao, Yiyue Zhang, Jin Xu, Meijia Zhang, Qiang Wang, Zilong Wen, Juan Shen, Wenqing Zhang, Zhibin Huang   +17 more
doaj   +1 more source

Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway

Molecules, 2021
Environmental di(2-Ethylhexyl) phthalate (DEHP) is widely used in various industries as a plasticizer, and has been reported to induce reproductive and developmental toxicities in organisms.
Huan Liu, Xiong Zhou, Shaowen Huang, Jie Yang, Ruijing Liu, Chunhong Liu   +5 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source