Results 51 to 60 of about 25,727 (222)

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Nature Communications, 2019
The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in ...
Xiaohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang, Hu Zhou, Ying Su, Xiao-kun Zhang   +8 more
doaj   +1 more source

Proteomic Analysis Reveals the Protective Effects of Yiqi Fumai Lyophilized Injection on Chronic Heart Failure by Improving Myocardial Energy Metabolism

Frontiers in Pharmacology, 2021
Yiqi Fumai lyophilized injection (YQFM) is the recombination of Sheng mai san (SMS).YQFM has been applied clinically to efficaciously and safely treat chronic heart failure (CHF). However, the mechanism of YQFM is still not fully elucidated.
Xiaoying Han, Yi Zhang, Ou Qiao, Haixia Ji, Xinyu Zhang, Wenzhe Wang, Xia Li, Juan Wang, Dekun Li, Aichun Ju, Changxiao Liu, Wenyuan Gao   +11 more
doaj   +1 more source

A shift in the Ligand Responsiveness of Thyroid Hormone Receptor α Induced by Heterodimerization with Retinoid X Receptor α [PDF]

Molecular and Cellular Biology, 1996
Thyroid hormone (T3) receptors (T3Rs) are ligand-modulated transcription factors that bind to thyroid hormone response elements (T3REs) and mediate either positive or negative transcriptional regulation of target genes. In addition, in response to ligand binding, T3Rs can interfere with AP-1 activity and thereby inhibit transcription of AP-1-responsive
Fahri Saatcioglu, Tony Antakly, Michael Karin, Francois Xavier Claret   +3 more
openaire   +3 more sources

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Nature Communications, 2017
The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its ...
Liqun Chen, Alexander E. Aleshin, Gulimiran Alitongbieke, Yuqi Zhou, Xindao Zhang, Xiaohong Ye, Mengjie Hu, Gaoang Ren, Ziwen Chen, Yue Ma, Duo Zhang, Shuai Liu, Weiwei Gao, Lijun Cai, Lingjuan Wu, Zhiping Zeng, Fuquan Jiang, Jie Liu, Hu Zhou, Gregory Cadwell, Robert C. Liddington, Ying Su, Xiao-kun Zhang   +22 more
doaj   +1 more source

Nuclear Receptors Are Differentially Expressed and Activated in KAIMRC1 Compared to MCF7 and MDA-MB231 Breast Cancer Cells

Molecules, 2019
We recently established a KAIMRC1 cell line that has unique features compared to the known breast cancer cell lines, MCF7 and MDA-MB231. To characterize it further, we investigated the expression profile of nuclear receptors and their respective co ...
Atef Nehdi, Rizwan Ali, Alshaimaa Alhallaj, Hajar Alzahrani, Nosaibah Samman, Abdullah Mashhour, Omar Baz, Tlili Barhoumi, Bandar Alghanem, Abdullatif Khan, Lolwah Alriyees, Mohamed Boudjelal   +11 more
doaj   +1 more source

Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)-α Pathway

Marine Drugs, 2019
Five new ergostanes, penicisteroids D−H (1−5), were isolated from the liquid culture of the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475, along with 27 known compounds. The structures of the new steroids were established mainly
Chun-Lan Xie, Duo Zhang, Jin-Mei Xia, Chao-Chao Hu, Ting Lin, Yu-Kun Lin, Guang-Hui Wang, Wen-Jing Tian, Zeng-Peng Li, Xiao-Kun Zhang, Xian-Wen Yang, Hai-Feng Chen   +11 more
doaj   +1 more source

Serum Proteomic Analysis of Cannabis Use Disorder in Male Patients

Molecules, 2021
Cannabis use has been growing recently and it is legally consumed in many countries. Cannabis has a variety of phytochemicals including cannabinoids, which might impair the peripheral systems responses affecting inflammatory and immunological pathways ...
Fawaz Alasmari, Sary Alsanea, Assim A. Alfadda, Ibrahim O. Alanazi, Mohthash Musambil, Afshan Masood, Faleh Alqahtani, Omer I. Fantoukh, Abdullah F. Alasmari, Hicham Benabdelkamel   +9 more
doaj   +1 more source

Effect of Retinoid Status on the Messenger Ribonucleic Acid Expression of Nuclear Retinoid Receptors α, β, and γ, and Retinoid X Receptors α, β, and γ in the Mouse Testis¹ [PDF]

Endocrinology, 1997
The testicular gene expression of the retinoic acid receptors, RAR alpha, -beta, and -gamma, was studied in normal mice and in vitamin A-deficient mice after the administration of all-trans-retinoic acid (ATRA). All three types of RARs were expressed in normal and/or vitamin A-deficient testes.
I. C. Gaemers, Ans M.M. van Pelt, Paul T. van der Saag, Axel P. N. Themmen, Dirk G. de Rooij, Jos W. Hoogerbrugge   +5 more
openaire   +3 more sources

In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer

Molecular Cancer, 2006
Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an agonist of the retinoid-X-receptor.
Charnock-Jones D Stephen, Holland Cathrine M, Saidi Samir A, Smith Stephen K   +3 more
doaj   +1 more source

Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha

BMC Cancer, 2008
Background The human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the participation of retinoid X receptors
Fraile Benito, Alba Emilio, González Francisco J, Pérez Julio, Zamora Javier, Lobo María VT, Conde Isabel, Paniagua Ricardo, Arenas María I   +8 more
doaj   +1 more source