Results 61 to 70 of about 25,727 (222)

Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease

Hepatology Communications, 2018
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adults. This study examined the relationship between hepatic nuclear receptor (NR) expression and histologic features of NAFLD.
Erin E. Elbel, Joel E. Lavine, Michael Downes, Mark Van Natta, Ruth Yu, Jeffrey B. Schwimmer, Cynthia Behling, Elizabeth M. Brunt, James Tonascia, Ronald Evans   +9 more
doaj   +1 more source

Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish

Nature Communications, 2023
Nonsteroidal anti-inflammatory drugs compose one of the most widely used classes of medications, but the risks for early development remain controversial, especially in the nervous system.
Wenwei Sun, Meimei Wang, Jun Zhao, Shuang Zhao, Wenchao Zhu, Xiaoting Wu, Feifei Li, Wei Liu, Zhuo Wang, Meng Gao, Yiyue Zhang, Jin Xu, Meijia Zhang, Qiang Wang, Zilong Wen, Juan Shen, Wenqing Zhang, Zhibin Huang   +17 more
doaj   +1 more source

Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway

Molecules, 2021
Environmental di(2-Ethylhexyl) phthalate (DEHP) is widely used in various industries as a plasticizer, and has been reported to induce reproductive and developmental toxicities in organisms.
Huan Liu, Xiong Zhou, Shaowen Huang, Jie Yang, Ruijing Liu, Chunhong Liu   +5 more
doaj   +1 more source

Stability of the Retinoid X Receptor-alpha Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide [PDF]

, 2020
ABSTRACTDifferential scanning calorimetry and differential scanning fluorimetry were used to measure the thermal stability of human retinoid X receptor-alpha ligand binding domain (RXRα LBD) homodimer in the absence or presence of rexinoid and coactivator peptide, GRIP-1.
Nathalia Melo, Zhengrong Yang, Donald D. Muccio, Matthew B. Renfrow, Venkatram R. Atigadda   +4 more
openaire   +2 more sources

In vivo stabilization of nuclear retinoid X receptor α in the presence of peroxisome proliferator‐activated receptor α [PDF]

FEBS Letters, 2003
Retinoid X receptor α (RXRα) can reveal diverse functions through forming a heterodimer with peroxisome proliferator‐activated receptor α (PPARα). However, the mechanism of regulation of the cellular RXRα level is unclear. Thus, quantitative change of RXRα was investigated in mouse liver.
Toshifumi Aoyama, Yuji Kamijo, Kazuhiko Hora, Naoki Tanaka, Hideki Makishima, Frank J. Gonzalez, Kendo Kiyosawa   +6 more
openaire   +3 more sources

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.

Proceedings of the National Academy of Sciences of the United States of America, 2001
Retinoid X receptor alpha (RXRalpha) is involved in multiple signaling pathways, as a heterodimeric partner of several nuclear receptors. To investigate its function in energy homeostasis, we have selectively ablated the RXRalpha gene in adipocytes of 4 ...
T. Imai, Ming Jiang, P. Chambon, D. Metzger   +3 more
semanticscholar   +1 more source

Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity [PDF]

Proceedings of the National Academy of Sciences, 2001
Retinoid X receptors (RXRs) are involved in a number of signaling pathways as heterodimeric partners of numerous nuclear receptors. Hepatocytes express high levels of the RXRα isotype, as well as several of its putative heterodimeric partners. Germ-line disruption (knockout) of RXRα has been shown to be lethalin utero, thus precluding analysis of its ...
Daniel Metzger, Philippe Kastner, Pierre Chambon, Ming Jiang, Takeshi Imai   +4 more
openaire   +3 more sources

Regulation of CYP3A genes by glucocorticoids in human lung cells [v1; ref status: indexed, http://f1000r.es/1f9]

F1000Research, 2013
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts, Chad D Moore, Erin G Romero, Robert M Ward, Garold S Yost, Christopher A Reilly   +5 more
doaj   +1 more source

Hyperphosphorylation of the Retinoid X Receptor α by Activated c-Jun NH2-terminal Kinases [PDF]

Journal of Biological Chemistry, 1999
The nuclear receptor mouse retinoid X receptor alpha (mRXRalpha) was shown to be constitutively phosphorylated in its NH2-terminal A/B region, which contains potential phosphorylation sites for proline-directed Ser/Thr kinases. Mutants for each putative site were generated and overexpressed in transfected COS-1 cells.
Cécile Rochette-Egly, Lucia Penna, Sylvie Adam-Stitah, Pierre Chambon   +3 more
openaire   +3 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source