Results 81 to 90 of about 14,401 (197)

Characterization of the ligand binding domain of human retinoid X receptor alpha expressed in Escherichia coli

Journal of Biological Chemistry, 1994
In order to study the structural details of ligand protein interactions of the human retinoid X receptor alpha (hRXR alpha), the DEF and EF domains of the receptor were expressed as glutathione S-transferase (GST) fusion proteins in Escherichia coli.
Lin Cheng, Andrew W. Norris, Bonnie F. Tate, M. Rosenberger, Joseph F. Grippo, E Li   +5 more
openalex   +3 more sources

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis

Acta Pharmaceutica Sinica B
Hepatic stellate cells (HSCs) are the primary fibrogenic cells in the liver, and their activation plays a crucial role in the development and progression of hepatic fibrosis.
Lijun Cai, Meimei Yin, Shuangzhou Peng, Fen Lin, Liangliang Lai, Xindao Zhang, Lei Xie, Chuanying Wang, Huiying Zhou, Yunfeng Zhan, Gulimiran Alitongbieke, Baohuan Lian, Zhibin Su, Tenghui Liu, Yuqi Zhou, Zongxi Li, Xiaohui Chen, Qi Zhao, Ting Deng, Lulu Chen, Jingwei Su, Luoyan Sheng, Ying Su, Ling-Juan Zhang, Fu-Quan Jiang, Xiao-Kun Zhang   +25 more
doaj   +1 more source

Dynamic enhancers control skeletal muscle identity and reprogramming.

PLoS Biology, 2019
Skeletal muscles consist of fibers of differing metabolic activities and contractility, which become remodeled in response to chronic exercise, but the epigenomic basis for muscle identity and adaptation remains poorly understood. Here, we used chromatin
Krithika Ramachandran, Madhavi D Senagolage, Meredith A Sommars, Christopher R Futtner, Yasuhiro Omura, Amanda L Allred, Grant D Barish   +6 more
doaj   +1 more source

The Integration of Epistasis Network and Functional Interactions in a GWAS Implicates RXR Pathway Genes in the Immune Response to Smallpox Vaccine.

PLoS ONE, 2016
Although many diseases and traits show large heritability, few genetic variants have been found to strongly separate phenotype groups by genotype. Complex regulatory networks of variants and expression of multiple genes lead to small individual-variant ...
Brett A McKinney, Caleb Lareau, Ann L Oberg, Richard B Kennedy, Inna G Ovsyannikova, Gregory A Poland   +5 more
doaj   +1 more source

Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRα antagonists

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Abnormal alterations in the expression and biological function of retinoid X receptor alpha (RXRα) have a key role in the development of cancer. Potential modulators of RXRα as anticancer agents are explored in growing numbers of studies.
Jingbo Qin, Jie Liu, Chunxiao Wu, Jianwen Xu, Bowen Tang, Kaiqiang Guo, Xiaohui Chen, Weihao Liu, Tong Wu, Hu Zhou, Meijuan Fang, Zhen Wu   +11 more
doaj   +1 more source

Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1. [PDF]

PLoS ONE, 2014
BACKGROUND: Farnesoid X receptor/retinoid X receptor-alpha (FXR/RXRα) is the master transcriptional regulator of bile salt synthesis and transport in liver and intestine.
Martijn O Hoeke, Janette Heegsma, Mark Hoekstra, Han Moshage, Klaas Nico Faber   +4 more
doaj   +1 more source

A Comprehensive Review of Acne Treatments: Unpacking the Chemical Structures and Effective Bioactive Compounds

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Acne vulgaris is a frequent skin disorder, affecting a large part of the population worldwide, and strongly influencing not only the physical but also the mental aspects of health. The choice of therapy for acne vulgaris is a very difficult one because the multifactorial causality of the disease and interindividual ...
Mobina Tajdari, Setare Abolghasemi, Elham Khanniri, Maryam Bayanati, Rahil Hakimimofrad, Mohammad Mahboubi‐Rabbani   +5 more
wiley   +1 more source

Decreased mRNA Levels of Retinoic Acid Receptor α, Retinoid X Receptor α and Thyroid Hormone Receptor α in Lesional Psoriatic Skin

Acta Dermato-Venereologica, 2000
Retinoic acid, vitamin D3 and triiodothyronine regulate keratinocyte proliferation and differentiation--processes that are disturbed in psoriatic skin--via binding to nuclear receptors for retinoic acid (RAR-alpha,-gamma), vitamin D3 (VDR), thyroid hormone (TR-alpha,-beta) plus the common heterodimer partners, the 9-cis-retinoic acid receptors (RXR ...
H, Törmä, T, Karlsson, G, Michaëlsson, O, Rollman, A, Vahlquist   +4 more
openaire   +2 more sources

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source