Results 131 to 140 of about 27,382 (293)

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

New synthetic retinoids: Effects on proliferation and differentiation [PDF]

, 1989
Nine retinoid analogues were synthesized and their effects on cell proliferation and differentiation of tumor cell lines were analysed and compared with those of natural retinoids (retinoic acid, retinol, retinal).
Barbieri R, Spandidos D, BARALDI, Pier Giovanni, GAMBARI, Roberto, SIMONI, Daniele, FERIOTTO, Giordana, Guarneri M, NASTRUZZI, Claudio, MANFREDINI, Stefano   +8 more
core  

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Retinoids in Dermatology [PDF]

Mayo Clinic Proceedings, 1987
M T, Goldfarb, C N, Ellis, J J, Voorhees
openaire   +2 more sources

New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer

Cancer Science, EarlyView.
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi, Sakura Hiraide Taniguchi, Yuya Yoshida   +2 more
wiley   +1 more source

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐ Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

National Delphi consensus on laser and energy‐based treatments for rosacea

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Various treatments are available for rosacea, including lasers and energy‐based devices (EBDs). However, the specific role of lasers and EBDs in rosacea management remains insufficiently defined in Germany. The aim of the study was to develop a comprehensive expert consensus on the use of lasers and EBDs in the treatment of rosacea ...
Lynhda Nguyen, Nikolaus Seeber, Uwe Paasch, Martin Schaller, Claudia Borelli, Syrus Karsai, Gerd Kautz, Tanja C. Fischer, Michael Drosner, Stefan Hammes, Konstantin Feise, Christian Raulin, Martina Kerscher, Gerd Gauglitz, Jens M. Baron, Stefan W. Schneider, Katharina Herberger   +16 more
wiley   +1 more source

Topical retinoids exposure during pregnancy. [PDF]

, 2008
Concerns have been raised with the topical use of retinoids since the publication of occasional cases associated with characteristic retinoid embryopathy, originally described after oral use. Epidemiological data are still scant.
De Santis, M., Schaefer, C., Berlin, M., Vial, T., Buclin, T., Stahl, B., Malm, H., Eleftheriou, G., Panchaud, A., Ieri, A.   +9 more
core  

Treatments for Molluscum contagiosum: A systematic review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Molluscum contagiosum (MC) is a viral skin infection that poses significant physical and psychosocial burdens, particularly in pediatric and immunocompromised populations. Despite the availability of various treatment options, comparative efficacy and safety data remain limited.
Ou Jia (Emilie) Wang, Mahek Shergill, Ammar Saed Aldien, Ilya Mukovozov   +3 more
wiley   +1 more source