Results 61 to 70 of about 16,489,844 (222)

Mechanism of pH-induced Release of Retinol from Retinol-Binding Protein [PDF]

, 1993
A hypothesis is proposed explaining the mechanism of pH-induced release of retinol from retinol-binding protein (RBP). A number of conservative positively charged side chains located on the retinol-binding face of the RBP molecule are involved in salt ...
A.L. Denesyuk, G. Zanotti, Ptitsyn, O.B., V.E. Bychkova, ZANOTTI, GIUSEPPE, DENESYUK A. I., BYCHKOVA V. E., O.B. Ptitsyn, Zanotti, G., PTYTSIN O. B., Denesyuk, A.L., Bychkova, V.E.   +11 more
core   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients. [PDF]

PLoS ONE, 2013
Retinol binding protein 4 (RBP4) is an adipokine that may contribute to the development of insulin resistance. However, how this adipokine is affected and its possible involvement in lipid metabolism in obese patients with varying degrees of insulin ...
Milagros Rocha, Celia Bañuls, Lorena Bellod, Susana Rovira-Llopis, Carlos Morillas, Eva Solá, Víctor M Víctor, Antonio Hernández-Mijares   +7 more
doaj   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Retinol Binding Protein 4 and Fatty Liver: A Direct Link? [PDF]

Hepatology, 2013
Retinol-binding protein 4 (RBP4) is a 21-kDa protein that facilitates the transport of retinol through the circulation to peripheral tissues. The principal source of RBP4 in the body is the liver. Hepatocytes are the primary producers of RBP4; they use the protein to contribute to total-body retinol homeostasis by complexing it with dietary retinol and
openaire   +2 more sources

Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundAdipokines are elaborated by adipose tissue and are associated with glycemic, lipid, and vascular traits. We hypothesized that in a cross‐sectional analysis circulating adipokines are altered among subsets of obesity stratified by presence ...
Justin P. Zachariah, Rene Quiroz, Kerrie P. Nelson, Zhaoyang Teng, John F. Keaney, Lisa M. Sullivan, Ramachandran S. Vasan   +6 more
doaj   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Circulating Retinol-Binding Protein 4 as a Possible Biomarker of Treatment Response for Ankylosing Spondylitis: An Array-Based Comparative Study

Frontiers in Pharmacology, 2020
ObjectiveTo explore proteins associated with ankylosing spondylitis (AS) and to investigate potential proteins that may predict treatment response of adalimumab (ADA) in AS patients.MethodsIn the discovery cohort, 39 AS patients and 20 healthy controls ...
Jialing Wu, Xinyu Wu, Zena Chen, Qing Lv, Mingcan Yang, Xuqi Zheng, Qiuxia Li, Yanli Zhang, Qiujing Wei, Shuangyan Cao, Xiaomin Li, Jun Qi, Minjing Zhao, Zetao Liao, Zhiming Lin, Jieruo Gu   +15 more
doaj   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Retinol-binding protein 4 in neonates born small for gestational age [PDF]

Journal of Endocrinological Investigation, 2010
Retinol-binding protein 4 (RBP4) is an adipocyte-derived 'signal' that may contribute to the pathogenesis of insulin resistance and Type 2 diabetes. The relationship of RBP4 with insulin resistance and metabolic risk in human beings has been the subject of several studies.
Giacomozzi C, GHIRRI, PAOLO, Lapolla R, Bartoli A, Scire G, Serino L, Germani D, BOLDRINI, ANTONIO, Cianfarani S.   +8 more
openaire   +4 more sources