Assessment of Serum Retinol Binding Protein 4 in Patients with Hepatocellular Carcinoma [PDF]
Introduction: Retinol Binding Protein 4 (RBP4) may be indirectly involved in the induction of carcinogenesis as it was identified as a key regulator of insulin resistance in obesity and diabetes.
Yehia Mohamed El Shazly +5 more
doaj +1 more source
A rapid versatile microassay for cellular retinol-binding protein using Lipidex-1000 microcolumns.
A new, rapid and versatile microassay for cellular retinol-binding protein has been developed based on separation of bound and free ligand by means of Lipidex-1000, a hydrophobic Sephadex derivative.
A M Timmers +3 more
doaj +1 more source
Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M. +20 more
core +1 more source
Objective Ischemic stroke (IS) is one of the major causes of disability and death worldwide. Effective prevention remains the best approach to reduce the burden of stroke.
Nearmeen M Rashad +5 more
doaj +1 more source
Retinol-binding protein 4 and insulin resistance in preeclampsia
Preeclampsia is characterized by the onset of high blood pressure and proteinuria during pregnancy, which results in substantial maternal and neonatal morbidity and mortality. Insulin resistance has been observed before the onset of preeclampsia, and is implicated in its pathophysiology. Recently, retinol-binding protein 4 (RBP4), which carries retinol
Masuyama, Hisashi +2 more
openaire +3 more sources
Retinol-Binding Protein-4 in Women With Untreated Essential Hypertension
Retinol-binding protein-4 (RBP4) is a novel adipokine able to modulate the action of insulin in several tissues. A variable degree of insulin resistance characterizes the vast majority of hypertensive (HYP) patients. The aim of this study was to evaluate the relationship between RBP4 and essential hypertension, exploring potential links between RBP4 ...
SOLINI, ANNA +4 more
openaire +3 more sources
Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo [PDF]
Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity (K(i) = 8.3 nm) non-retinoid ligand for RBP4, which disrupts the interaction between RBP4 and its binding partner transthyretin.
Alykhan, Motani +16 more
openaire +2 more sources
Role of Apolipoprotein D and Its Homologs, in Normal and Pathological Aging, in Drosophila melanogaster [PDF]
The free radical theory of aging is probably the most enduring one to date. It stipulates that, in the process of normal cellular function, in particular due to oxygen-based respiration, reactive oxygen species are formed.
Muffat, Julien A.
core +1 more source
Adipocytokine levels mark endothelial function in normotensive individuals
Background Endothelial dysfunction is an independent risk factor for cardiovascular events. Inflammatory mediators released by the adipose tissue can lead to local insulin resistance and endothelial dysfunction.
Solini Anna +6 more
doaj +1 more source
Aims/Introduction Excessive dietary salt or low potassium intakes are strongly correlated with insulin resistance (IR) and type 2 diabetes mellitus. In epidemiological and experimental studies, increased serum retinol‐binding protein 4 (RBP4) contributes
Fuqiang Liu +14 more
doaj +1 more source

