Results 21 to 30 of about 16,489,844 (222)

Retinol-Binding Protein 4 in Human Obesity [PDF]

Diabetes, 2006
Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes.
Jürgen, Janke, Stefan, Engeli, Michael, Boschmann, Frauke, Adams, Jana, Böhnke, Friedrich C, Luft, Arya M, Sharma, Jens, Jordan   +7 more
openaire   +2 more sources

Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk. [PDF]

Circ Res, 2022
Background: Despite mechanistic studies linking retinol and RBP4 (retinol binding protein 4) to the pathogenesis of cardiovascular diseases (CVD) and type 2 diabetes (T2D), epidemiological evidence is still conflicting. We investigated whether conflicting results of previous studies may be explained by differences in the ...
Schiborn C, Weber D, Grune T, Biemann R, Jäger S, Neu N, Müller von Blumencron M, Fritsche A, Weikert C, Schulze MB, Wittenbecher C.   +10 more
europepmc   +7 more sources

Retinol-Binding Protein 4 in Twins [PDF]

Diabetes, 2009
OBJECTIVE—Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose
Ribel-Madsen, Rasmus, Friedrichsen, Martin, Vaag, Allan, Poulsen, Pernille   +3 more
openaire   +3 more sources

Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation

Metabolites, 2022
Signalling between the tissues integrating synthesis, transformation and utilization of energy substrates and their regulatory hormonal axes play a substantial role in the development of metabolic disorders.
Daniela Dadej, Ewelina Szczepanek-Parulska, Marek Ruchała   +2 more
doaj   +1 more source

Retinol-binding protein 4 in obesity [PDF]

, 2020
Although many preventive and treatment approaches have been proposed, cardiovascular disease (CVD) remains one of the leading causes of deaths worldwide. Current epidemiological data require the specification of new causative factors, as well as the development of improved diagnostic tools to provide better cardiovascular management.
Anna Maria Rychter, Marzena Skrzypczak-Zielinska, Aleksandra Zielińska, Piotr Eder, Eliana B. Souto, Agnieszka Zawada, Alicja Ewa Ratajczak, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak   +8 more
openaire   +1 more source

Serum retinol-binding protein 4 as a predictor of fibrosis regression and response to direct-acting antiviral drugs in chronic hepatitis C virus patients

Egyptian Liver Journal, 2023
Background Hepatitis C virus is the underlying cause of chronic hepatitis which frequently progresses to cirrhosis and hepatocellular carcinoma. In addition, HCV is thought to cause steatosis, dyslipidemia, insulin resistance, diabetes, obesity, and ...
Hany Samir Rasmy, Mohammed Abd Elfattah Elmalatawy, Khaled Zakaria ElKarmoty, Ebrahim Youssef Abdelwarth, Amira Isaac   +4 more
doaj   +1 more source

The Metabolic Role of Retinol Binding Protein 4: An Update [PDF]

Hormone and Metabolic Research, 2011
Retinol binding protein 4 (RBP(4)) is regarded as a novel cardiometabolic risk factor, which is secreted mainly by the hepatocytes and also by the adipose tissue. RBP(4) has been shown to induce insulin resistance, and plasma RBP(4) values are increased in type 2 diabetes mellitus, obesity, metabolic syndrome, and cardiovascular disease.
Christou, G. A., Tselepis, A. D., Kiortsis, D. N.   +2 more
openaire   +3 more sources

Retinol-binding protein 4 in obesity and metabolic dysfunctions

Molecular and Cellular Endocrinology, 2021
Excessive increased adipose tissue mass in obesity is associated with numerous co-morbid disorders including increased risk of type 2 diabetes, fatty liver disease, hypertension, dyslipidemia, cardiovascular diseases, dementia, airway disease and some cancers. The causal mechanisms explaining these associations are not fully understood.
Nono Nankam, P.A., Blüher, M.
openaire   +3 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Retinol Binding Protein 4 Serves as a Potential Tumor Biomarker and Promotes Malignant Behavior in Gastric Cancer. [PDF]

Cancer Manag Res
Yantao Yu,1– 3,* Chenkai Zhang,2,3,* Qiannan Sun,2– 4 Shantanu Baral,2,3 Jianyue Ding,2,3 Fanyu Zhao,2,3 Qing Yao,2,3 Shuyang Gao,2,3 Bin Liu,2– 4 Daorong Wang1– 4 1The Yangzhou School of Clinical Medicine of Dalian Medical University, Yangzhou ...
Yu Y, Zhang C, Sun Q, Baral S, Ding J, Zhao F, Yao Q, Gao S, Liu B, Wang D.   +9 more
europepmc   +2 more sources