Results 91 to 100 of about 93,616 (252)

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source

Comparison of the Effects of Supplemental Red Palm Oil and Sunflower oil on Maternal Vitamin A Status. [PDF]

, 2001
Conflicting results have been reported on the ability of dietary carotenoids to improve vitamin A status in lactating women. Red palm oil is one of the richest dietary sources of beta-carotene.
Ballart, A, Henry, C J, Lietz, G, Lorri, W, Mugyabuso, J K, Mulokozi, G, Ndossi, G D, Tomkins, A   +7 more
core   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting

EMBO Reports
Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively from hepatocytes, thereby mobilizing hepatic retinoid stores that ...
Julia S Steinhoff, Carina Wagner, Henriette E Dähnhardt, Kristina Košić, Yueming Meng, Ulrike Taschler, Laura Pajed, Na Yang, Sascha Wulff, Marie F Kiefer, Konstantin M Petricek, Roberto E Flores, Chen Li, Sarah Dittrich, Manuela Sommerfeld, Hervé Guillou, Andrea Henze, Jens Raila, Sylvia J Wowro, Gabriele Schoiswohl, Achim Lass, Michael Schupp   +21 more
doaj   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Retinol metabolism in rats with low vitamin A status: a compartmental model

Journal of Lipid Research, 1990
A compartmental model was developed to describe the metabolism of vitamin A in rats with low vitamin A status maintained by a low dietary intake of vitamin A (approximately 2 micrograms retinol equivalents/day).
KC Lewis, MH Green, JB Green, LA Zech
doaj   +1 more source

Novel Histopathologic Features of Diffuse Blue‐Gray Hyperpigmentation Associated With Kratom Use: A Case Report and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Drug‐induced hyperpigmentation accounts for 10%–20% of acquired pigmentary disorders and can be misdiagnosed for other causes such as melasma, post inflammatory changes, or heavy metal deposition. Kratom (Mitragyna speciosa), a Southeast Asian plant with an opioid‐like profile, has been increasingly used in the United States for ...
Rita Kamoua, Kristen Paradine, Craig A. Rohan, Mary McDaniel, Diane Perkins   +4 more
wiley   +1 more source

Serum retinol concentration in patients with acute falciparum malaria

Journal of Infection in Developing Countries, 2009
Background: Vitamin A (retinol)-deficiency and falciparum malaria are two major public health problems in developing countries. Falciparum malaria is associated with significant destruction of erythrocytes and can lead to severe anaemia.
Adil Raza, Haris M Khan, Mohd. Ashraf Malik, Abbas Ali Mahdi, Mohd. Shahid, Fatima Shujatullah   +5 more
doaj   +1 more source

A Computational Approach for Identifying Plant-Based Foods for Addressing Vitamin Deficiency Diseases [PDF]

, 2015
Vitamins are nutrients that are essential to human health, and deficiencies have been shown to cause severe diseases. In this study, a computational approach was used to identify vitamin deficiency diseases and plant-based foods with vitamin content ...
Sarkar, Indra Neil, Yu, Christina
core   +1 more source

A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer

The FEBS Journal, EarlyView.
Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge, Srđan Vujinović, Alexander Scholten, Karl‐Wilhelm Koch   +3 more
wiley   +1 more source