Results 71 to 80 of about 37,733 (224)
Mechanism of pH‐induced release of retinol from retinol‐binding protein
A hypothesis is proposed explaining the mechanism of pH‐induced release of retinol from retinol‐binding protein (RBP). A number of conservative positively charged side chains located on the retinol‐binding face of the RBP molecule are involved in salt bridges with conservative negatively charged groups.
PTYTSIN O. B.+3 more
openaire +4 more sources
Perfusion feeding in rats induced a decrease in circulating retinol despite an adequate supply of vitamin A. We studied the effect of total parenteral nutrition (TPN) on the retinol specific carrier in rat, analyzing holo-RBP (bound to retinol) and apo ...
A Lespine+7 more
doaj
Release of retinol and denaturation of its plasma carrier, retinol-binding protein
Retinol is tightly packed inside the structure of its plasma carrier (retinol-binding protein, RBP). It was found that retinol release from RBP to aqueous solutions is facilitated by either very low pH or very high temperatures (i.e. by non-physiological conditions that cause protein denaturation).
Andrea Fantuzzi+4 more
openaire +3 more sources
Retinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.
The mechanisms of retinol transport and accumulation in hepatic stellate cells (HSC) remain to be elucidated. Our previous studies suggested that retinol esterification activity, particularly lecithin:retinol acyltransferase (LRAT) activity, in liver retinoid metabolism is important to elucidate the relationship between retinol uptake by HSC and the ...
Seishi Nagamori+3 more
openaire +4 more sources
New insights into applications of base editor in hereditary disorders
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai+8 more
wiley +1 more source
Vitamin A metabolism: analysis of steady-state neutral metabolites in rat tissues.
High-performance liquid chromatography systems were developed to rapidly separate retinol from its esters, analyze the total spectrum of neutral vitamin A compounds, and purify retinyl esters to homogeneity.
J B Williams, B C Pramanik, J L Napoli
doaj
Cambios en las concentraciones de retinol, hemoglobina y ferritina en niños palúdicos colombianos
Introducción. La malaria, la anemia y las parasitosis coexisten en niños colombianos. Se desconoce el efecto del suplemento de retinol y de los antiparasitarios sobre estos problemas de salud y la evolución de la hemoglobina, el retinol, la ferritina y ...
Rosa Magdalena Uscátegui+2 more
doaj +1 more source
We experimentally impaired the pre‐laying condition of female starlings by clipping two flight feathers per wing at the beginning of the breeding season, before egg laying. Impaired females laid the same number of eggs as control females, but smaller, and with higher levels of yolk vitamin A.
S. Casquero+5 more
wiley +1 more source
Recent Advancements in the Treatment of Age‐Related Macular Degeneration
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu+10 more
wiley +1 more source
Understanding Retinol Metabolism: Structure and Function of Retinol Dehydrogenases [PDF]
Martin Lidén, Ulf Eriksson
openaire +3 more sources