Results 111 to 120 of about 42,594 (242)

Causal Effects of Type 2 Diabetes Mellitus on Chronic Periodontitis and the Mediating Role of Oxidative Stress: Evidence From Mendelian Randomization and Mediation Analysis

open access: yesOral Diseases, EarlyView.
ABSTRACT Background Type 2 diabetes mellitus (T2DM) is associated with an increased risk of chronic periodontitis, but genetic evidence and oxidative stress‐related pathways remain unclear. Objective This study assessed the genetically inferred association between T2DM and chronic periodontitis, evaluated oxidative stress biomarkers as potential ...
Mengjie Kong   +3 more
wiley   +1 more source

Photodegradation of commercial insect repellents containing DEET and IR‐3535 under ultraviolet light associated or not with chemical ultraviolet filters evaluated by Raman spectroscopy

open access: yesPhotochemistry and Photobiology, EarlyView.
This study evaluated the photodegradation of commercial insect repellents containing DEET and IR‐3535 under UV‐A and UV‐B irradiation using Raman spectroscopy. Pure DEET and IR‐3535 showed intrinsic photostability, whereas DEET diluted in ethanol and a commercial DEET‐based formulation exhibited significant spectral changes after UV exposure.
Viviane Gadret Borio   +4 more
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

open access: yesExperimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler   +2 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor   +4 more
wiley   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego   +10 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

open access: yesMedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony

open access: yesPROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.
ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung   +4 more
wiley   +1 more source

Dietary Supplementation of Olive Pomace in Lactating Buffaloes: Effects on Milk and Yogurt Composition and Fatty Acid Profile

open access: yesVeterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Olive pomace in lactating buffaloes: Fifteen lactating buffaloes were fed with 0%, 7.5%, and 15% olive pomace substituted with wheat flour for 45 days. Replacing olive pomace with wheat flour in the diet of lactating buffaloes increased milk fat, the concentration of short‐chain and unsaturated fatty acids, and conjugated fatty acids.
Tahereh Mohammadabadi   +2 more
wiley   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

open access: yesAndrology, Volume 14, Issue 6, Page 1472-1478, September 2026.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik   +3 more
wiley   +1 more source

Free Fatty Acids Carried by Lipoproteins: Revisiting the Overlooked Cargo

open access: yesActa Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Free fatty acids (FFAs) are hydrophobic and therefore cannot enter the bloodstream at appreciable levels unless they are solubilized by FFA carriers. Albumin has been appreciated for years as the major FFA carrier, but it is not the only carrier.
Gregory C. Henderson   +2 more
wiley   +1 more source

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