Results 131 to 140 of about 42,594 (242)

Bilateral Upper Extremity Superficial Venous Thrombosis and Altered Mental Status as Initial Manifestations of Aggressive B‐Cell Lymphoma: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
Schematic representation of the disease progression, diagnostic workup, treatment course, and final clinical outcome. ABSTRACT A 72‐year‐old woman with fever, confusion, and upper extremity superficial venous thrombosis was admitted. Despite screening for infectious, neurologic, and autoimmune causes, no diagnosis was established.
Milad Rezvani   +5 more
wiley   +1 more source

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang   +19 more
wiley   +1 more source

Generation and Characterization of a Rdh1‐iCre Line to Study Uterine Glandular Biology

open access: yesgenesis, Volume 64, Issue 4, August 2026.
ABSTRACT The uterus is an essential organ for fetal development in most mammals. Uterine glands, highly conserved structures in the mammalian uterus, play critical roles in the establishment and maintenance of pregnancy and have been implicated in the pathogenesis of uterine diseases, including endometrial cancer and endometriosis.
Mana Ohtomo   +11 more
wiley   +1 more source

Update on the Management of ABCA4 Retinopathy (Stargardt Disease). [PDF]

open access: yesOphthalmol Ther
Parameswarappa DC   +3 more
europepmc   +1 more source

Prevalence of Clinical Vitamin A Deficiency and Associated Factors Among Children Aged 24–59 Months in Finote Selam Town, Ethiopia: A Community Based Cross‐Sectional Study, 2022

open access: yesHealth Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Vitamin A deficiency is a public health problem in developing countries including Ethiopia. Thus, its prevalence and associated factors in each locality is essential for tackling the problem since the cause differs across geographical areas and community to community.
Molla Mekuria   +5 more
wiley   +1 more source

Immunometabolic Dysregulation in Obesity: Integrating Macrophage Polarization, Metabolic Reprogramming, and Gut Microbiota Crosstalk

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Obesity is characterized by chronic low‐grade systemic inflammation, in which adipose tissue macrophages (ATMs) play a pivotal role in driving immune and metabolic dysfunction. Objective This review summarizes current evidence on the roles of ATMs in obese adipose tissue and examines how macrophage polarization and metabolic ...
Yuanyuan Li   +11 more
wiley   +1 more source

ASGR1 Deficiency Promotes Liver Fibrosis by Enhancing Pro‐Inflammatory Arachidonic Acid Metabolism and ALP Secretion

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Asialoglycoprotein receptor 1 (ASGR1), a hepatocyte‐specific receptor, represents a potential therapeutic target for hypercholesterolemia. However, liver safety risks of ASGR1‐targeted therapies remain poorly characterized. This study aims to investigate the impact of ASGR1 deficency on liver fibrosis and its underlying mechanisms ...
Hui Zhu   +9 more
wiley   +1 more source

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