Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
eLife, 2014 Retinol plays a vital role in the immune response to infection, yet proteins that mediate retinol transport during infection have not been identified.
Mehabaw G Derebe +8 more
doaj +3 more sources
High resolution crystal structure data of human plasma retinol-binding protein (RBP4) bound to retinol and fatty acids [PDF]
Data in Brief, 2018 Retinol is transported in vertebrate plasma bound to a protein called retinol-binding protein (RBP4) so far believed to be specific for the vitamin. When the protein is saturated with retinol it binds tightly to another plasma protein, transthyretin ...
Massimiliano Perduca +4 more
doaj +2 more sources
Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk
Circulation Research, 2022 Background: Despite mechanistic studies linking retinol and RBP4 (retinol binding protein 4) to the pathogenesis of cardiovascular diseases (CVD) and type 2 diabetes (T2D), epidemiological evidence is still conflicting. We investigated whether conflicting results of previous studies may be explained by differences in the ...
Catarina Schiborn +10 more
openaire +7 more sources
Human plasma retinol-binding protein (RBP4) is also a fatty acid-binding protein. [PDF]
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2018 RBP4 (plasma retinol-binding protein) is the 21 kDa transporter of all-trans retinol that circulates in plasma as a moderately tight 1:1 molar complex of the vitamin with the protein.
M. Perduca +4 more
semanticscholar +2 more sources
Role of retinol-binding protein 4 in obese Asian Indians with metabolic syndrome [PDF]
Journal of Medical Biochemistry, 2012 Retinol-binding protein 4 is an adipocytokine separately implicated in the development of obesity-related insulin resistance and proatherogenic lipid profile, however, its role in humans is unclear.
Shivakumar Nirupama +8 more
doaj +2 more sources
Science Advances, 2020 Retinol-binding protein 2 (RBP2) binds 2-monoacylglycerols affecting their intestinal levels and enteroendocrine responses. Expressed in the small intestine, retinol-binding protein 2 (RBP2) facilitates dietary retinoid absorption. Rbp2-deficient (Rbp2−/−
Seung-Ah Lee +15 more
semanticscholar +2 more sources
Mechanism of pH‐induced release of retinol from retinol‐binding protein
FEBS Letters, 1993 A hypothesis is proposed explaining the mechanism of pH‐induced release of retinol from retinol‐binding protein (RBP). A number of conservative positively charged side chains located on the retinol‐binding face of the RBP molecule are involved in salt bridges with conservative negatively charged groups.
PTYTSIN O. B. +3 more
openaire +3 more sources
Possible Interacting Proteins for Retinol Binding Protein and Cellular Retinol Binding Protein [PDF]
, 2011 Retinol or vitamin A is crucial for many biological processes in the body such as proliferation, differentiation and reproduction. It is mainly stored in the liver and can be broken down to retinoic acid inside the cell. It travels in the circulatory system attached to Retinol Binding Protein (RBP) and its transport into the cell is mediated by the RBP
Cooney, David
core +4 more sources
Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction [PDF]
, 2021 Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of pro-amyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology.
Arun, Raja +7 more
core +1 more source
Interplay of retinol binding protein 4 with obesity and associated chronic alterations
Molecular Medicine Reports, 2022 Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue. Adipose tissue is responsible for the production and secretion of numerous adipokines that induce metabolic disorders.
Yaccil Adilene Flores-Cortez +5 more
semanticscholar +1 more source