Results 21 to 30 of about 2,216,238 (221)

Liver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4) [PDF]

Journal of Biological Chemistry, 2013
Vitamin A (retinol) is absorbed in the small intestine, stored in liver, and secreted into circulation bound to serum retinol-binding protein (RBP4). Circulating retinol may be taken up by extrahepatic tissues or recycled back to liver multiple times before it is finally metabolized or degraded.
Philomena, Alapatt, Fangjian, Guo, Susan M, Komanetsky, Shuping, Wang, Jinjin, Cai, Ashot, Sargsyan, Eduardo, Rodríguez Díaz, Brandon T, Bacon, Pratik, Aryal, Timothy E, Graham   +9 more
openaire   +2 more sources

Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis

Molecular Metabolism, 2020
Objective: Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming
Anna Fenzl, Oana Cristina Kulterer, Katrin Spirk, Goran Mitulović, Rodrig Marculescu, Martin Bilban, Sabina Baumgartner-Parzer, Alexandra Kautzky-Willer, Lukas Kenner, Jorge Plutzky, Loredana Quadro, Florian W. Kiefer   +11 more
doaj   +1 more source

Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport

Frontiers in Cell and Developmental Biology, 2023
The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function.
Rakesh Radhakrishnan, Matthias Leung, Ashish K. Solanki, Glenn P. Lobo, Glenn P. Lobo, Glenn P. Lobo   +5 more
doaj   +1 more source

Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study [PDF]

, 2015
Background Serum retinol concentration determined by high-performance liquid chromatography (HPLC) is recommended by the World Health Organization to assess population vitamin A status.
Inge D Brouwer, Verhoef, H., Elise F Talsma, Alida Melse-Boonstra, Brouwer, Inge D, Hulshof, Paul JM, Talsma, E.F., Anne S Mburu-de Wagt, Paul JM Hulshof, Hans Verhoef, Talsma, Elise F, Mburu-de Wagt, Anne S, Melse-Boonstra, Alida, Brouwer, I.D., Hulshof, P.J.M., Mburu-de Wagt, A.S., Verhoef, Hans, Boonstra, A., Talsma, E.F.; Verhoef, H.; Brouwer, I.D.; Mburu-de Wagt, A.S.; Hulshof, P.J.M.; Melse-Boonstra, A.   +18 more
core   +2 more sources

A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores.

Journal of Lipid Research, 1985
A linear, first-order, constant-coefficient multicompartmental model is presented which describes the dynamics of [3H]retinol turnover in adult rats with normal plasma retinol concentrations but low liver stores (less than 100 micrograms of retinol ...
M H Green, L Uhl, J B Green
doaj   +1 more source

Confocal Raman imaging reveals the impact of retinoids on human breast cancer via monitoring the redox status of cytochrome c

Scientific Reports, 2023
This paper expands the current state of knowledge on impact of retinoids on redox status of cytochrome c in cancers. Little is known how the expression of cytochromes may influence the development of cancers.
Jakub Maciej Surmacki, Halina Abramczyk
doaj   +1 more source

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol [PDF]

Journal of the American Society of Nephrology, 1999
Abstract. Transepithelial transport of retinol is linked to retinol-binding protein (RBP), which is taken up and also synthesized in a number of epithelia. By immunocytochemistry of human, rat, and mouse renal proximal tubules, a strong staining in apical endocytic vacuoles, lysosomes, endoplasmic reticulum, Golgi, and basal ...
Christensen, Erik Ilsø, Moskaug, J.Ø., Vorum, Henrik, Jacobsen, Christian, Gundersen, T.E., Nykjær, Anders; id_orcid 0000-0001-6422-6736, Blomhoff, R., Willnow, T.E., Moestrup, Søren Kragh   +8 more
openaire   +3 more sources

Retinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.

Cell Structure and Function, 1999
The mechanisms of retinol transport and accumulation in hepatic stellate cells (HSC) remain to be elucidated. Our previous studies suggested that retinol esterification activity, particularly lecithin:retinol acyltransferase (LRAT) activity, in liver retinoid metabolism is important to elucidate the relationship between retinol uptake by HSC and the ...
T, Matsuura, S, Hasumura, S, Nagamori, K, Murakami   +3 more
openaire   +3 more sources

Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. [PDF]

PLoS ONE, 2012
BACKGROUND: Retinoids are a class of compounds that are chemically related to vitamin A, which is an essential nutrient that plays a key role in vision, cell growth and differentiation. In vivo, retinoids must bind with specific proteins to perform their
Yu-Ru Zhang, Yu-Qi Zhao, Jing-Fei Huang
doaj   +1 more source