Results 51 to 60 of about 2,216,238 (221)

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Retinol and Retinol-Binding Protein Stabilize Transthyretin via Formation of Retinol Transport Complex

, 2016
Transthyretin (TTR) is a plasma hormone carrier protein associated with hereditary and senile forms of systemic amyloid disease, wherein slow tetramer disassembly is thought to be an obligatory step. Plasma transport of retinol is carried out exclusively
Stéphanie Deroo (1616770), Suk-Joon Hyung (244117), Carol V. Robinson (244129)   +2 more
core   +1 more source

Age‐Dependent Prognostic Significance of Preoperative Transthyretin After Curative Resection for Stage I–III Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Preoperative malnutrition and systemic inflammation are established determinants of adverse outcomes in colorectal cancer (CRC). Transthyretin (TTR), a rapid‐turnover hepatic protein, reflects both nutritional and inflammatory status; however, its clinical utility may be influenced by age‐ and sex‐related variability.
Ayane Kawata, Yuji Miyamoto, Hiro Nakamura, Takahiko Akiyama, Kota Arima, Katsuhiro Ogawa, Yukiharu Hiyoshi, Masaaki Iwatsuki   +7 more
wiley   +1 more source

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Vitamin A (retinol) handling during health and disease.

, 2019
(A) During homeostasis, gut bacteria suppress the conversion of dietary retinol into RA and promote its storage. Retinol transporter RBP4 is the main transporter of retinol to and from the liver.
Shipra Vaishnava (6808382), Namrata Iyer (359169)   +1 more
core   +1 more source

Adaptive evolution of the STRA6 genes in mammalian. [PDF]

PLoS ONE, 2014
Stimulated by retinoic acid 6 (STRA6) is the receptor for retinol binding protein and is relevant for the transport of retinol to specific sites such as the eye.
Jianghong Wu, Hui Xiang, Yunxia Qi, Ding Yang, Xiaojuan Wang, Hailian Sun, Feng Wang, Bin Liu   +7 more
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness

, 2010
Objective: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. While retinol is associated with various cardiovascular risk factors, the relation between retinol, RBP4, TTR and carotid ...
Andreas F.H. Pfeiffer, Bobbert, Thomas, Franziska Schwarz, Thomas Bobbert, Knut Mai, Andrea Henze, Florian J. Schweigert, Joachim Spranger, Spranger, Joachim (Prof. Dr. med.), Mai, Knut, Jens Raila, Schwarz, Franziska, Pfeiffer, Andreas F. H. (Prof. Dr.), Schweigert, Florian Johannes (Prof. Dr.), Raila, Jens (Prof. Dr.), Henze, Andrea (Dr.)   +15 more
core   +1 more source

Transport outlook 2009: Globalisation, crisis and transport [PDF]

, 2009
This second ITF Transport Outlook continues building towards a full-fledged Transport Outlook, building upon the first Outlook (JTRC, 20081). The 2008 Outlook investigated the relation between expected GDP evolution and the demand for road transport ...
International Transport Forum, OECD
core   +2 more sources

Retinol semisolid preparations in cosmetics: transcutaneous permeation mechanism and behaviour

Scientific Reports
Retinol is widely used to treat skin ageing because of its effect on cell differentiation, proliferation and apoptosis. However, its potential benefits appear to be limited by its skin permeability.
Yuan Wang, Qirong Zhang, Yongsheng Wei, Xiang Cai, Zhiwei Li, Qingyun Wu, Xinyi Zhang, Chaoqing Deng, Peng Shu, Qi Xiang   +9 more
doaj   +1 more source