Results 1 to 10 of about 168,869 (309)

Advanced baseline immunosuppression is associated with elevated levels of plasma markers of fungal translocation and inflammation in long-term treated HIV-infected Tanzanians

AIDS Research and Therapy, 2021
Background For over a decade, antiretroviral therapy (ART) in resource-limited countries was only recommended for patients with advanced HIV disease.
Godfrey Barabona, Macdonald Mahiti, Mako Toyoda, Doreen Kamori, Salim Masoud, George P. Judicate, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno   +8 more
doaj   +1 more source

HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev

Scientific Reports, 2022
During HIV infection, intron-containing viral mRNAs are exported from the cell nucleus to the cytoplasm to complete the replication cycle. Cellular restrictions on the export of incompletely spliced transcripts are overcome by a viral protein, Rev, and ...
Godfrey Dzhivhuho, Jordan Holsey, Ethan Honeycutt, Heather O’Farrell, David Rekosh, Marie-Louise Hammarskjold, Patrick E. H. Jackson   +6 more
doaj   +1 more source

Development and characterization of a panel of anti-idiotype antibodies to 1C10 that cross-neutralize HIV-1 subtype B viruses

Frontiers in Virology, 2022
The V3 loop of the human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is one of the conserved immunogenic regions targeted by neutralizing antibodies (nAb).
Yu Kaku, Kaho Matsumoto, Takeo Kuwata, Hasan Md Zahid, Shashwata Biswas, Miroslaw K. Gorny, Shuzo Matsushita   +6 more
doaj   +1 more source

Functional analysis of a monoclonal antibody reactive against the C1C2 of Env obtained from a patient infected with HIV-1 CRF02_AG

Retrovirology, 2021
Background Recent data suggest the importance of non-neutralizing antibodies (nnAbs) in the development of vaccines against HIV-1 because two types of nnAbs that recognize the coreceptor binding site (CoRBS) and the C1C2 region mediate antibody-dependent
Hasan Md Zahid, Takeo Kuwata, Shokichi Takahama, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Hirokazu Tamamura, Shuzo Matsushita   +7 more
doaj   +1 more source

Retrovirus molecular conjugates [PDF]

Cellular and Molecular Life Sciences (CMLS), 2001
Retrovirus-derived vectors are currently the preferred vectors used for human gene therapy protocols. Serious safety concerns persist, however, which are specifically related to the formation of a replication-competent virus, and no synthesis method currently employed precludes its formation with certainty.
Q, Zhong, J K, Kolls, P, Schwarzenberger
openaire   +2 more sources

Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants

mBio, 2023
The rapid spread and strong immune evasion of the SARS-CoV-2 Omicron subvariants has raised serious concerns for the global COVID-19 pandemic. These new variants exhibit generally reduced fusogenicity and increased endosomal entry pathway utilization ...
Panke Qu, John P. Evans, Chaitanya Kurhade, Cong Zeng, Yi-Min Zheng, Kai Xu, Pei-Yong Shi, Xuping Xie, Shan-Lu Liu   +8 more
doaj   +1 more source

Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine

Nature Communications, 2022
mRNA vaccines have been shown to prevent SARS-CoV-2 infection and reduce hospitalization and mortality rates. Here, the authors show evidence of long-term memory CD8 + T cells in individuals who received the BNT162b2 SARS-CoV-2 mRNA vaccine.
Nozomi Kuse, Yu Zhang, Takayuki Chikata, Hung The Nguyen, Shinichi Oka, Hiroyuki Gatanaga, Masafumi Takiguchi   +6 more
doaj   +1 more source

Phenotypic and Genotypic Co-receptor Tropism Testing in HIV-1 Epidemic Region of Tanzania Where Multiple Non-B Subtypes Co-circulate

Frontiers in Microbiology, 2021
HIV human immunodeficiency virus type I (HIV-1) entry inhibitor potency is dependent on viral co-receptor tropisms and thereby tropism determination is clinically important.
George P. Judicate, Godfrey Barabona, Doreen Kamori, Macdonald Mahiti, Toong Seng Tan, Seiya Ozono, Amina Shaban Mgunya, Takeo Kuwata, Shuzo Matsushita, Bruno Sunguya, Bruno Sunguya, Eligius Lyamuya, Eligius Lyamuya, Kenzo Tokunaga, Kenzo Tokunaga, Takamasa Ueno, Takamasa Ueno   +16 more
doaj   +1 more source

Th17 and Th17/Treg ratio at early HIV infection associate with protective HIV-specific CD8+ T-cell responses and disease progression [PDF]

, 2015
The aim of this study was to analyze Th17 and Treg subsets and their correlation with anti-HIV T-cell responses and clinical parameters during (acute/early) primary HIV infection (PHI) and up to one year post-infection (p.i).
Cahn, Pedro, Falivene, Juliana, Figueroa, María Inés, Gherardi, Maria Magdalena, Ghiglione, Yanina Alexandra, Giavedoni, Luis D., Holgado, María Pía, Laufer, Natalia Lorna, Maeto, Cynthia Alejandra, Ruiz, Maria Julia, Salomon, Horacio Eduardo, Socías, María Eugenia, Sued, Omar Gustavo, Turk, Gabriela Julia Ana   +13 more
core   +1 more source

Larger mammalian body size leads to lower retroviral activity [PDF]

, 2014
Retroviruses have been infecting mammals for at least 100 million years, leaving descendants in host genomes known as endogenous retroviruses (ERVs). The abundance of ERVs is partly determined by their mode of replication, but it has also been suggested ...
Belshaw, Robert, Gifford, Robert, Gupta, Sunetra, Katzourakis, Aris, Lim, Aaron G., Magiorkinis, Gkikas   +5 more
core   +8 more sources