Results 151 to 160 of about 161,769 (345)
British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Treating Hematological Malignancies With OR‐2100, an Orally Bioavailable Prodrug of Decitabine
Cancer Science, Volume 116, Issue 4, Page 853-861, April 2025.We have developed a silylated derivative of decitabine, OR‐2100, which is resistant to degradation by cytidine deaminase and orally bioavailable. In this article, we review the current status of DNA demethylating agents for treating hematological malignancies, with a focus on OR‐2100. ABSTRACT DNA methylation is an enzyme‐driven epigenetic modification
Tatsuro Watanabe +2 more
wiley +1 more source
Secretion of human parathyroid hormone from rat pituitary cells infected with a recombinant retrovirus encoding preproparathyroid hormone. [PDF]
, 1984 J G Hellerman +5 more
openalex +1 more source
Role of the avian retrovirus mRNA leader in expression: evidence for novel translational control. [PDF]
, 1986 Richard A. Katz +3 more
openalex +1 more source
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
Nature, 1984 A. Dalgleish +5 more
semanticscholar +1 more source
Hyaluronan treatment of biotinylated packaging cells increases titre of progeny retrovirus affinity-captured onto paramagnetic particles [PDF]
, 2015 BACKGROUND: The polysaccharide hyaluronan is a major component of the extracellular matrix and has been observed to impact retrovirus infectivity in biological settings.
Nesbeth, DN
core
Cancer Science, EarlyView.Our findings show that feeder cells expressing CD80, 41BBL and membrane‐bound IL‐21 promote optimal NK cell expansion. We also evaluated CAR transduction efficiency into expanded NK cells using different lentiviral vectors. The results indicate that NK cells transduced with the BaeV lentivirus exhibit high cytotoxicity toward target cells.
Thi Bao Tram Tran +12 more
wiley +1 more source
Cell Proliferation, Volume 58, Issue 4, April 2025.This manuscript provides a comprehensive overview of the state‐of‐the‐art in non‐viral CAR‐NK cell engineering, highlighting its potential to revolutionise cancer treatment. ABSTRACT The recent advancements in cancer immunotherapy have spotlighted the potential of natural killer (NK) cells, particularly chimeric antigen receptor (CAR)–transduced NK ...
Zhaokai Zhou +18 more
wiley +1 more source