Results 171 to 180 of about 157,125 (279)

Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms

open access: yesCancer Science, Volume 117, Issue 4, Page 896-903, April 2026.
In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley   +1 more source

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan   +3 more
wiley   +1 more source

Evolutionary Dynamics of Endogenous Feline Leukemia Virus in the Felis Genus Through the Lens of Genomics

open access: yesAnnals of the New York Academy of Sciences, Volume 1558, Issue 1, April 2026.
The endogenous form of Gammaretrovirus felleu (feline leukemia virus; enFeLV) modulates exogenous infections. Mining of felid genomes confirmed that enFeLV is restricted to the Felis genus. Sequence analysis indicates retention of transcriptional and integrational capacity in Felis catus and introgression in the Felis chaus germline.
Ricardo Mouta   +6 more
wiley   +1 more source

Metastatic potential of ovine pulmonary adenocarcinoma: a comprehensive assessment of the draining pulmonary lymph nodes. [PDF]

open access: yesJ Vet Diagn Invest
Hodor D   +17 more
europepmc   +1 more source

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