Results 131 to 140 of about 122,151 (262)

Mechanistic Study of GSDME and CXCL10 in SUV39H1‐Mediated Pyroptosis and Immune Suppression in Cervical Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Cervical cancer (CC) remains a major global health challenge characterized by high incidence and mortality. The histone methyltransferase suppressor of variegation 3–9 homolog 1 (SUV39H1) has emerged as a key epigenetic regulator in tumor progression, but its role in modulating pyroptosis and remodeling of the immune microenvironment in CC ...
Li Zhang, Peiting Sheng, Dongge Cai, Ziyue Zhao, Xiaoling Wu, Yan'e Gao   +5 more
wiley   +1 more source

Early skewed differentiation and PD-1 expression in CD4+ cells relate to immune dysfunction and viral persistence in individuals living with HIV 1 year post-cART initiation

Journal of Virus Eradication, 2019
J. Salido, A. Czernikier, C. Trifone, M.I. Figueroa, H. Salomón, P. Cahn, O. Sued, N. Laufer, Y. Ghiglione, G. Turk   +9 more
doaj   +1 more source

M11‐CAR T cells inhibit murine cytomegalovirus in vitro upon recognition of virion‐ and cell‐associated glycoprotein B

Clinical &Translational Immunology, Volume 15, Issue 11, 2026.
Abstract Objectives Viral infections are predominantly managed with conventional antiviral drugs, which, despite their efficacy, can cause toxicity and promote resistance. Cell‐based immunotherapies offer an alternative, but cytomegaloviruses (CMV) profoundly interfere with MHC class I antigen presentation, thereby impairing conventional virus‐specific
Sabrina Kübel, Christopher Garçon, Hanna Menschikowski, Arne Cordsmeier, Jens‐Christian Albrecht, Friederike Oltmanns, Larissa Bauer, Manuel Hermann, Kristina Holdt, Heinrich Sticht, Marco Thomas, Thomas H Winkler, Brigitte Scholz, Doris Jungnickl, Armin Ensser   +14 more
wiley   +1 more source

MEK1/2 Signalling establishes an alloreactive effector T cell program through SMAD4 during cardiac allograft rejection

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Upon T cell receptor (TCR) engagement by alloantigens, MEK1/2–ERK1/2 signalling promotes SMAD4 nuclear translocation and supports SMAD4‐dependent transcription of effector genes, including Ifng, Tnf, and Il2ra. This transcriptional program promotes alloreactive T cell effector function and contributes to cardiac allograft rejection.
Jiulu Zhao, Shuan Ran, Sijie Zhou, Yuan Li, Wang Zhan, Longyong Lai, Jikai Cui, Jiahong Xia, Jie Wu   +8 more
wiley   +1 more source

Analyse der transkriptionellen Regulation des humanen endogenen Retrovirus HTDV/HERV-K [PDF]

, 2004
Das humane Genom besteht zu etwa 8% aus retroviralen Sequenzen. Davon sind ca. 1-2% dem humanen endogenen Retrovirus K (HERV-K) zuzuordnen. Das Virus ist mit ca. 30-50 Proviren und ca. 10.000 sLTRs im humanen Genom vertreten.
Kraft, Martin
core  

Galectin-1 promotes HIV-1 latency reactivation

Journal of Virus Eradication, 2019
J. Rubione, G. Duette, P. Perez, P. Pereyra Gerber, J. Salido, A. Cagnoni, L. Guzman, A. Adamczyk, O. Sued, Y. Ghiglione, N. Laufer, K. Mariño, G. Rabinovich, M. Ostrowski   +13 more
doaj   +1 more source

Modulation of the RNA‐sensing RIG/MAVS pathway bypasses resistance to hypomethylating agents in acute myeloid leukemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract DNA hypomethylating agents (HMAs) such as 5‐azacytidine (5‐AZA) are a cornerstone in the treatment of acute myeloid leukemia (AML), but development of resistance represents a major clinical challenge. Apart from epigenetic reprogramming of malignant cell clones, therapy with HMA is increasingly recognized to facilitate antineoplastic immunity,
Nadia El Khawanky, Tatiana Nedelko, Giada Mandracci, Yunus Barth, Yuan Jiang, Kai Wang, Marc Rosenbaum, Christin Weiß, Christoph Geisenberger, Stefan Enßle, Ana M. Gómez Martínez, Sascha Göttert, Noomen Hamed, Julius C. Fischer, Jürgen Ruland, Dirk H. Busch, Hendrik Poeck, Katharina S. Götze, Anna L. Illert, Florian Bassermann, Simon M. Heidegger   +20 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

B‐Cell Follicles in the Secondary Lymphatic Tissues Act as a Critical Microanatomical Niche for Sustained Viral Replication, Virus‐Host Interaction and Damage During Chronic SIV Infection of Rhesus Macaques

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT Most people living with HIV‐1 (HIV) are diagnosed during the chronic stage of infection, at which point viral setpoint has been established and a substantial immunopathologic damage in the secondary lymphatic tissues (LTs) has been induced. To better characterize virus‐host interaction and immunopathologic damage in LTs, we investigated viral ...
Yilun Cheng, Miaoyun Zhao, Jackson Chen, Subhra Mandal, Mark G. Lewis, Qingsheng Li   +5 more
wiley   +1 more source

CRISPR Technology: From Bench to Bedside Applications

MedComm, Volume 7, Issue 11, November 2026.
This review systematically dissects the molecular mechanisms, advantages, and limitations of core CRISPR editing platforms including base editors (Panel A) and prime editing (Panel B); summarizes pivotal clinical data across hemoglobinopathies, CAR‐T immunotherapy, muscular dystrophy, cystic fibrosis, cardiometabolic diseases, and rare monogenic ...
Xinzhi Ma, Lingyu Li, Yingli Sun
wiley   +1 more source