Results 121 to 130 of about 117,013 (259)

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

, 2010
Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological
Mameli, Giuseppe, S. Sotgiu, Arru, Giannina, G. Mameli, Zarbo, Ir, Dolei, Antonina, A. Dolei, IR Zarbo, Sotgiu, Stefano, Serra, Caterina, C. Serra, G. Arru, Zarbo IR   +12 more
core   +1 more source

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo, Li Li, Fang Wang, Wen Liu, Yan Zhang   +4 more
wiley   +1 more source

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes in lymph nodes and reduces SHIV RNA

Journal of Virus Eradication, 2017
G. Pavlakis, D.C. Watson, E. Moysi, A. Valentin, C. Bergamaschi, S. Devasundaram, S.P. Fortis, J. Bear, E. Chertova, J. Bess, Jr., R. Sowder, D.J. Venzon, C. Deleage, J.D. Estes, J.D. Lifson, C. Petrovas, B.K. Felber   +16 more
doaj   +1 more source

Machine learning-assisted decoding of temporal transcriptional dynamics via fluorescent timer

Nature Communications
Investigating the temporal dynamics of gene expression is crucial for understanding gene regulation across various biological processes. Using the Fluorescent Timer protein, the Timer-of-cell-kinetics-and-activity system enables analysis of ...
Nobuko Irie, Naoki Takeda, Yorifumi Satou, Kimi Araki, Masahiro Ono   +4 more
doaj   +1 more source

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

Cell Genomics
Summary: Antiviral proteins often evolve rapidly at virus-binding interfaces to defend against new viruses. We investigated whether antiviral adaptation via missense mutations might face limits, which insertion or deletion mutations (indels) could ...
Jeannette L. Tenthorey, Serena del Banco, Ishrak Ramzan, Hayley Klingenberg, Chang Liu, Michael Emerman, Harmit S. Malik   +6 more
doaj   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Kinetics of HIV production by monocyte derived macrophages (MDM) in the presence of erythrocytes

Journal of Virus Eradication, 2015
L. Fazzi, C.G. Cevallos, R.D. Rabinovich, M.M. Ávila   +3 more
doaj   +1 more source

Transcriptome analysis of HPV16-positive cells expressing intrabodies targeting E6 and E7 oncoproteins to unravel intrabody antitumor activity

Journal of Translational Medicine
Background Human Papillomavirus-associated cancer remains a global health issue despite the availability of prophylactic vaccination. Two single-chain recombinant antibodies specific for the high-risk HPV16-E6 and E7 oncoproteins were previously ...
Susanna Falcucci, Sabrina Tait, Maria Vincenza Chiantore, Anna Rita Ciccaglione, Carla Amici, Paola Di Bonito, Luisa Accardi   +6 more
doaj   +1 more source

Testicular toll with viral intrusion: Molecular insights into the impact of chronic HIV infection on male fertility

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Tousif Ahmed Hediyal, Elizabeth M. Stone, Omar Shukri, Victoria L. Schaal, Amin Foroughi‐Nezhad, Murali Devanaboyina, Josef S. Crenshaw, Amir Elrefaie, Sree Kolli, Camryn N. Davis, Dinesh Pradhan, Sowmya V. Yelamanchili, Gurudutt Pendyala   +12 more
wiley   +1 more source

Retrovirus receptors

Cell, 1995
Weiss, Robin A., Tailor, Chetankumar S.
openaire   +2 more sources