Results 101 to 110 of about 157,125 (279)
No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms [PDF]
, 2007 Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic ...
Burmeister, Thomas +4 more
core +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The FEBS Journal, EarlyView.The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl +11 more
wiley +1 more source
Herpes Simplex 2 Virus Depletes Cells of DEAD-Box Helicase 3 Protein by Packaging It into Virions
VirusesHuman DEAD-box helicase 3 (DDX3) is a multifunctional RNA helicase implicated in mRNA unwinding and the regulation of gene expression. While DDX3 has been extensively studied in the context of RNA virus replication, its role in DNA virus replication ...
Carmen Rita Piazza +8 more
doaj +1 more source
Retroviral Vectors for Analysis of Viral Mutagenesis and Recombination
Viruses, 2014 Retrovirus population diversity within infected hosts is commonly high due in part to elevated rates of replication, mutation, and recombination. This high genetic diversity often complicates the development of effective diagnostics, vaccines, and ...
Jonathan M.O. Rawson, Louis M. Mansky
doaj +1 more source
The FEBS Journal, EarlyView.Divalent metal transporter 1 (Dmt1) maintains iron homeostasis and lysosomal proteostasis required for physiological Notch receptor–ligand signaling. Dmt1 loss lowers iron storage capacity (ferritin), increasing intracellular Fe2+, driving ROS and lipid peroxidation, and leading to lysosomal/mitochondrial dysfunction.
Rui Zhang +5 more
wiley +1 more source
Journal of VirologyHuman endogenous retrovirus K (HERV-K) proviruses of the HML-2 subgroup are the most recently integrated retroviral elements within the human genome. The HERV-K Rec protein, a functional homolog of HIV Rev, is essential for the expression of viral mRNAs ...
Katarzyna Zurowska +4 more
doaj +1 more source
Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia
Haemophilia, EarlyView.ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh +5 more
wiley +1 more source
Immunology, EarlyView.Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto +14 more
wiley +1 more source
Remnants of an Ancient Deltaretrovirus in the Genomes of Horseshoe Bats (Rhinolophidae)
Viruses, 2018 Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other ...
Tomáš Hron +7 more
doaj +1 more source
, 1991 Newsletter of the Evans Memorial Department of Clinical Research and Preventive Medicine at University ...
Levinsky, Norman G. +1 more
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