Results 101 to 110 of about 117,013 (259)

The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases [PDF]

, 2009
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Master of PhilosophyHuman endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome.
Smith, Richard G.
core   +1 more source

Retroviral Vectors for Analysis of Viral Mutagenesis and Recombination

Viruses, 2014
Retrovirus population diversity within infected hosts is commonly high due in part to elevated rates of replication, mutation, and recombination. This high genetic diversity often complicates the development of effective diagnostics, vaccines, and ...
Jonathan M.O. Rawson, Louis M. Mansky
doaj   +1 more source

An Integrated Analysis of Manganese Metabolism‐Related Genes and Their Association With Biomarkers, Immune Infiltration, and Clinical Subtypes in Alzheimer's Disease

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu, Jiahao Hu, Shanshan Hu, Yefeng Yao   +3 more
wiley   +1 more source

Herpes Simplex 2 Virus Depletes Cells of DEAD-Box Helicase 3 Protein by Packaging It into Virions

Viruses
Human DEAD-box helicase 3 (DDX3) is a multifunctional RNA helicase implicated in mRNA unwinding and the regulation of gene expression. While DDX3 has been extensively studied in the context of RNA virus replication, its role in DNA virus replication ...
Carmen Rita Piazza, Giulia Lottini, Paola Quaranta, Paola Perrera, Fabio Filippini, Michele Lai, Cristina Di Primio, Giulia Freer, Mauro Pistello   +8 more
doaj   +1 more source

Reconstitution of an infectious human endogenous retrovirus.

, 2007
The human genome represents a fossil record of ancient retroviruses that once replicated in the ancestors of contemporary humans. Indeed, approximately 8% of human DNA is composed of sequences that are recognizably retroviral.
Lee Young Nam, Paul D. Bieniasz, Paul D Bieniasz, Bieniasz Paul D, Young Nam Lee   +4 more
core   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, Volume 49, Issue 10, October 2026.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

Characterization of HERV-K (HML-2) Rec proteins encoded in the human genome and their post-transcriptional function

Journal of Virology
Human endogenous retrovirus K (HERV-K) proviruses of the HML-2 subgroup are the most recently integrated retroviral elements within the human genome. The HERV-K Rec protein, a functional homolog of HIV Rev, is essential for the expression of viral mRNAs ...
Katarzyna Zurowska, Godfrey Dzhivhuho, David Grabski, David Rekosh, Marie-Louise Hammarskjold   +4 more
doaj   +1 more source

Inositol pyrophosphate kinases in health and disease

FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.
In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu   +6 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, Volume 600, Issue 17, Page 2420-2436, September 2026.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source