Results 81 to 90 of about 117,013 (259)

HIV-Tocky system to visualize proviral expression dynamics

Communications Biology
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and virus-mediated killing.
Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono, Kenji Maeda, Masahiro Ono, Hiroaki Takeuchi, Yorifumi Satou   +13 more
doaj   +1 more source

Imaging Flow Cytometry in HIV Infection Research: Advantages and Opportunities

Methods and Protocols
The human immunodeficiency virus (HIV) is a type of retrovirus that infects humans and belongs to the Lentivirus group. Despite the availability of effective treatments, HIV infections are still increasing in some parts of the world, according to the ...
Kirill. A. Elfimov, Dmitriy. A. Baboshko, Natalya. M. Gashnikova   +2 more
doaj   +1 more source

A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat

mBio, 2020
Bats are primary reservoirs for multiple lethal human viruses, such as Ebola, Nipah, Hendra, rabies, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), and, most recently, SARS-CoV-2.
James H. Morrison, Caitlin Miller, Laura Bankers, Gary Crameri, Lin-Fa Wang, Eric M. Poeschla   +5 more
doaj   +1 more source

Performance of point‐of‐care tests for diagnosing feline immunodeficiency virus infection in captive African lions (Panthera leo)

Australian Veterinary Journal, EarlyView.
Point‐of‐care (PoC) antibody (Ab) testing forms an integral component of feline immunodeficiency virus (FIV) diagnosis in both domestic and non‐domestic felids, with test kits designed for use in domestic cats frequently extrapolated for use in their wild counterparts. The SNAP® FIV/FeLV Combo lateral flow ELISA is commonly used to assign FIV infection
SE Jobbins, ME Westman, K Vinette Herrin, T Meili, R Hofmann‐Lehmann, JM Norris   +5 more
wiley   +1 more source

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity

Journal of Virology
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus responsible for adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neurodegenerative disease.
Emily M. King, Amanda Midkiff, Karsyn McClain, Sanggu Kim, Amanda R. Panfil   +4 more
doaj   +1 more source

North American Big Brown Bats (Eptesicus fuscus) Harbor an Exogenous Deltaretrovirus

mSphere, 2020
Bats are the reservoir for a large number of zoonotic viruses, including members of Coronaviridae (severe acute respiratory syndrome coronavirus [SARS-CoV] and SARS-CoV-2), Paramyxoviridae (Hendra and Nipah viruses), Rhabdoviridae (rabies virus), and ...
Ben M. Hause, Eric A. Nelson, Jane Christopher-Hennings   +2 more
doaj   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

The FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito, Miori Murayama, Usaki Arai, Sekifumi Akatsu, Ami Yamamoto, Misaki Kadoguchi, Noritaka Adachi   +6 more
wiley   +1 more source

4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages

Immunology, EarlyView.
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley   +1 more source

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source