Results 141 to 150 of about 122,151 (262)
This review summarizes current therapeutic and prophylactic strategies for global viral diseases, including vaccines, PrEP, direct‐acting antivirals, and emerging modalities such as CRISPR and siRNA. It highlights their clinical impact, ongoing challenges, and future priorities toward broader protection, improved delivery, and more effective antiviral ...
Sawar Khan +12 more
wiley +1 more source
Purpose: To analyze antibody profiles in retrovirus-seronegative and seropositive cats after vaccination or field infection with feline panleukopenia virus (FPV), feline herpesvirus type 1 (FHV-1), and feline calicivirus (FCV).
D. PROVERBIO +3 more
core +1 more source
Mitochondria in Viral Infections: Molecular Mechanisms and Therapeutic Targets
Viral infections remodel mitochondrial function through direct viral regulation and infection‐induced changes in host cellular processes. These alterations affect OXPHOS, mitochondrial metabolism, calcium homeostasis, membrane potential, redox regulation, dynamics, and apoptosis, with distinct effects on viral replication and host antiviral responses ...
Ha Young Oh, Hye Jin Shin
wiley +1 more source
Point‐of‐care (PoC) antibody (Ab) testing forms an integral component of feline immunodeficiency virus (FIV) diagnosis in both domestic and non‐domestic felids, with test kits designed for use in domestic cats frequently extrapolated for use in their wild counterparts. The SNAP® FIV/FeLV Combo lateral flow ELISA is commonly used to assign FIV infection
SE Jobbins +5 more
wiley +1 more source
Evolutionary dynamics of polymorphic endogenous retrovirus insertions across wild house mouse populations. [PDF]
Yano T +7 more
europepmc +1 more source
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal +16 more
wiley +1 more source
The <i>JAK2</i> V617F revolution in myeloproliferative neoplasms. [PDF]
Tefferi A.
europepmc +1 more source
Unmasking the Influence of Viral Micro‐RNAs on Host Immunity
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton +1 more
wiley +1 more source
4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley +1 more source
From biomarkers to intervention: Translational potential of endogenous retrovirus-derived chimeric RNAs. [PDF]
Ouyang Z, Liang H, Zhang D.
europepmc +1 more source

