Results 31 to 40 of about 165,526 (354)

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.

Journal of Clinical Investigation, 2008
Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34+ BM precursor cells using gammaretroviral vectors. While 9 of 10 patients were successfully treated,
S. Hacein-Bey-Abina, A. Garrigue, Gary P. Wang, J. Soulier, A. Lim, E. Morillon, E. Clappier, L. Caccavelli, É. Delabesse, K. Beldjord, V. Asnafi, E. Macintyre, L. Dal Cortivo, I. Radford, N. Brousse, F. Sigaux, D. Moshous, J. Hauer, A. Borkhardt, B. Belohradsky, U. Wintergerst, M. Vélez, L. Leiva, R. Sorensen, N. Wulffraat, S. Blanche, F. Bushman, A. Fischer, M. Cavazzana‐Calvo   +28 more
semanticscholar   +1 more source

Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

Nature Communications, 2022
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al.
Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya, Shinsuke Nakajima, Masahito Tokunaga, Kisato Nosaka, Hiroyuki Hata, Atae Utsunomiya, Jun-ichi Fujisawa, Yorifumi Satou   +16 more
doaj   +1 more source

Human endogenous retrovirus-K (HML-2): a comprehensive review

Critical reviews in microbiology, 2018
The human genome contains a large number of retroviral elements acquired over the process of evolution, some of which are specific to primates. However, as many of these are defective or silenced through epigenetic changes, they were historically ...
M. Garcia-Montojo, Tara T. Doucet-O’Hare, L. Henderson, A. Nath   +3 more
semanticscholar   +1 more source

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

Biomolecules, 2023
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL). HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host antiviral immunity; however, 5–10% of carriers lose this balance and develop ATL.
Shingo Nakahata, Daniel Enriquez-Vera, M. Ishrat Jahan, Kenji Sugata, Yorifumi Satou   +4 more
doaj   +1 more source

Remnants of an ancient deltaretrovirus in the genomes of horseshoe aats (Rhinolophidae) [PDF]

, 2018
Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other ...
Benda, Petr, Elleder, Daniel, Farkašová, Helena, Gifford, Robert J., Görföl, Tamás, Hron, Tomáš, Hulva, Pavel, Pačes, Jan   +7 more
core   +2 more sources

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Proceedings of the National Academy of Sciences of the United States of America, 1982
A retrovirus (ATLV) was unequivocally demonstrated in human adult T-cell leukemia (ATL) cell lines by density (1.152-1.155 g/cm3) in a sucrose gradient, reverse transcriptase activity insensitive to actinomycin D, RNA labeled with [3H]uridine, and ...
M. Yoshida, I. Miyoshi, Y. Hinuma
semanticscholar   +1 more source

Retrovirus Restriction Factors [PDF]

Molecular Cell, 2004
A number of cellular genes have recently been identified that actively inhibit retrovirus replication and so protect cells from infection. The genes target many distinct steps in the viral life cycle: entry, viral DNA synthesis, intracellular movement of viral nucleic acids, and viral gene expression.
openaire   +3 more sources

Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?

Viruses, 2015
Background: indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas.
Camila Cánepa, Jimena Salido, Matías Ruggieri, Sindy Fraile, Gabriela Pataccini, Carolina Berini, Mirna Biglione   +6 more
doaj   +1 more source

Nomenclature for endogenous retrovirus (ERV) loci

Retrovirology, 2018
Retroviral integration into germline DNA can result in the formation of a vertically inherited proviral sequence called an endogenous retrovirus (ERV).
R. Gifford, J. Blomberg, J. Coffin, H. Fan, T. Heidmann, J. Mayer, J. Stoye, M. Tristem, W. Johnson   +8 more
semanticscholar   +1 more source

HIV Env conserved element DNA vaccine alters immunodominance in macaques

Human Vaccines & Immunotherapeutics, 2017
Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of ‘conserved’ and ‘variable’ regions.
Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber   +12 more
doaj   +1 more source