Results 31 to 40 of about 161,769 (345)

Progress, challenges, and responsibilities in retrovirology [PDF]

, 2005
In this editorial, Retrovirology's choice for best basic science "retrovirus paper of the year" and a perspective on challenges and responsibilities facing HIV-1 and HTLV-I research are ...
Jeang, Kuan-Teh
core   +3 more sources

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.

Journal of Clinical Investigation, 2008
Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) gene to CD34+ BM precursor cells using gammaretroviral vectors. While 9 of 10 patients were successfully treated,
S. Hacein-Bey-Abina, A. Garrigue, Gary P. Wang, J. Soulier, A. Lim, E. Morillon, E. Clappier, L. Caccavelli, É. Delabesse, K. Beldjord, V. Asnafi, E. Macintyre, L. Dal Cortivo, I. Radford, N. Brousse, F. Sigaux, D. Moshous, J. Hauer, A. Borkhardt, B. Belohradsky, U. Wintergerst, M. Vélez, L. Leiva, R. Sorensen, N. Wulffraat, S. Blanche, F. Bushman, A. Fischer, M. Cavazzana‐Calvo   +28 more
semanticscholar   +1 more source

Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?

Viruses, 2015
Background: indeterminate Western blot (WB) patterns are a major concern for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1) infection, even in non-endemic areas.
Camila Cánepa, Jimena Salido, Matías Ruggieri, Sindy Fraile, Gabriela Pataccini, Carolina Berini, Mirna Biglione   +6 more
doaj   +1 more source

Human endogenous retrovirus-K (HML-2): a comprehensive review

Critical reviews in microbiology, 2018
The human genome contains a large number of retroviral elements acquired over the process of evolution, some of which are specific to primates. However, as many of these are defective or silenced through epigenetic changes, they were historically ...
M. Garcia-Montojo, Tara T. Doucet-O’Hare, L. Henderson, A. Nath   +3 more
semanticscholar   +1 more source

Retrovirus Restriction Factors [PDF]

Molecular Cell, 2004
A number of cellular genes have recently been identified that actively inhibit retrovirus replication and so protect cells from infection. The genes target many distinct steps in the viral life cycle: entry, viral DNA synthesis, intracellular movement of viral nucleic acids, and viral gene expression.
openaire   +3 more sources

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

Proceedings of the National Academy of Sciences of the United States of America, 1982
A retrovirus (ATLV) was unequivocally demonstrated in human adult T-cell leukemia (ATL) cell lines by density (1.152-1.155 g/cm3) in a sucrose gradient, reverse transcriptase activity insensitive to actinomycin D, RNA labeled with [3H]uridine, and ...
M. Yoshida, I. Miyoshi, Y. Hinuma
semanticscholar   +1 more source

Distribution, diversity and evolution of endogenous retroviruses in perissodactyl genomes [PDF]

, 2018
The evolution of mammalian genomes has been shaped by interactions with endogenous retroviruses (ERVs). In this study, we investigated the distribution and diversity of ERVs in the mammalian order Perissodactyla, with a view to understanding their impact
Gifford, Robert, Murcia, Pablo Ramiro, Zhu, Henan   +2 more
core   +1 more source

HIV Env conserved element DNA vaccine alters immunodominance in macaques

Human Vaccines & Immunotherapeutics, 2017
Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of ‘conserved’ and ‘variable’ regions.
Xintao Hu, Antonio Valentin, Margherita Rosati, Siriphan Manocheewa, Candido Alicea, Bhabadeb Chowdhury, Jenifer Bear, Kate E. Broderick, Niranjan Y. Sardesai, Sylvie Le Gall, James I. Mullins, George N. Pavlakis, Barbara K. Felber   +12 more
doaj   +1 more source

Nomenclature for endogenous retrovirus (ERV) loci

Retrovirology, 2018
Retroviral integration into germline DNA can result in the formation of a vertically inherited proviral sequence called an endogenous retrovirus (ERV).
R. Gifford, J. Blomberg, J. Coffin, H. Fan, T. Heidmann, J. Mayer, J. Stoye, M. Tristem, W. Johnson   +8 more
semanticscholar   +1 more source

The extraordinary evolutionary history of the reticuloendotheliosis viruses [PDF]

, 2013
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely
A Katzourakis, A Katzourakis, A Stamatakis, AC van der Kuyl, AD Yoder, AL Hughes, AM Awad, AM Fadly, Anna Maria Niewiadomska, Bill Sugden, BR Burmester, C Feschotte, C Hertig, CG Ludford, CG Ludford, CN Dren, CN Dren, CN Dren, CR Parrish, CY Kang, CY Lin, DC Nickle, DH Huson, DH Ley, DJ McGeoch, DS Arathy, DW Trampel, E Prukner-Radovcic, EH Dearborn, F Abascal, F Rodriguez, FR Robinson, H Koyama, HC Carlson, HG Purchase, HM Koo, I Davidson, IS Diallo, IS Diallo, J Hanson, J Li, J Martin, JJ Solomon, JP Stoye, JP Vanderberg, JS McDougall, K Nyakatura, KA Schat, KM Moore, LA Terzian, LE Hayes, LJ Yu, LT Coggeshall, M Barbacid, M Garcia, MJ Peterson, MK Cook, ML Drew, MR Patel, MW Dimmic, MX Motha, N Ratnamohan, N Yuasa, P Singh, PE Miller, PS Paul, PS Sarma, Q Liu, R Crespo, R Gifford, R Isfort, RA Weiss, RB Franklin, RB Franklin, RJ Isfort, RL Witter, RL Witter, RL Witter, RM Corwin, Robert J. Gifford, SB Hitchner, SK Biswas, SL Kosakovsky Pond, T Barbosa, T Tadese, TJ Kim, TM Grimes, VN Kewalramani, W Trager, WG Conway, WH Cheng, Y Wang, Z Cheng, Z Cui, Z Yang, É Brumpt   +95 more
core   +3 more sources