Results 81 to 90 of about 165,526 (354)

Bookmarking the epigenome by retrovirus integration [PDF]

Retrovirology, 2011
Integration of retroviruses occurs in most genomic regions with weak but statistical significant preferences for target site sequences. HIV-1 preferentially targets genes, particularly the transcriptionally active ones. Avian sarcoma and leukosis viruses (ASLV) integrate with only slight preference for genes while murine leukemia virus uniquely favors ...
Jiri Hejnar, Miroslav Auxt, Filip Šenigl   +2 more
openaire   +3 more sources

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source

HIV-Tocky system to visualize proviral expression dynamics

Communications Biology
Determinants of HIV-1 latency establishment are yet to be elucidated. HIV reservoir comprises a rare fraction of infected cells that can survive host and virus-mediated killing.
Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono, Kenji Maeda, Masahiro Ono, Hiroaki Takeuchi, Yorifumi Satou   +13 more
doaj   +1 more source

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.

Proceedings of the National Academy of Sciences of the United States of America, 1996
We have generated a human 293-derived retroviral packaging cell line (293GPG) capable of producing high titers of recombinant Moloney murine leukemia virus particles that have incorporated the vesicular stomatitis virus G (VSV-G) protein.
D. Ory, Beverly I. Neugeboren, R. Mulligan   +2 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response

Frontiers in Immunology, 2017
The innate immune response constitutes the first cellular line of defense against initial HIV-1 infection. Immune cells sense invading virus and trigger signaling cascades that induce antiviral defenses to control or eliminate infection.
Jenna M. Antonucci, Corine St. Gelais, Li Wu   +2 more
doaj   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer. [PDF]

, 1987
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals.
Bordignon, C, Eglitis, MA, Gillio, AP, Kantoff, PW, Karson, E, Kernan, NA, Kohn, DB, McLachlin, JR, Moen, RC, Yu, SF   +9 more
core  

The Mongoose, the Pheasant, the Pox, and the Retrovirus

PLoS Biology, 2013
Paleovirology is the study of ancient viruses. The existence of a paleovirus can sometimes be detected by virtue of its accidental insertion into the germline of different animal species, which allows one to date when the virus actually existed. However, the ancient and the modern often connect, as modern viruses have unexpected origins that can be ...
Lucie Etienne, Michael Emerman
openaire   +5 more sources