Results 31 to 40 of about 68,205 (163)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Nuclear Trafficking of Retroviral RNAs and Gag Proteins during Late Steps of Replication

Viruses, 2013
Retroviruses exploit nuclear trafficking machinery at several distinct stages in their replication cycles. In this review, we will focus primarily on nucleocytoplasmic trafficking events that occur after the completion of reverse transcription and ...
Matthew S. Stake, Darrin V. Bann, Rebecca J. Kaddis, Leslie J. Parent   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Role of Lipids in Retrovirus Replication

Viruses, 2010
Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell.
Abdul A. Waheed, Eric O. Freed
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Cross- and Co-Packaging of Retroviral RNAs and Their Consequences

Viruses, 2016
Retroviruses belong to the family Retroviridae and are ribonucleoprotein (RNP) particles that contain a dimeric RNA genome. Retroviral particle assembly is a complex process, and how the virus is able to recognize and specifically capture the genomic RNA
Lizna M. Ali, Tahir A. Rizvi, Farah Mustafa   +2 more
doaj   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Genetic landscape of Italian SRLV: insights from passive surveillance-based phylogenetic analysis

Frontiers in Microbiology
Small ruminant lentiviruses (SRLVs) are retroviruses infecting small ruminants, characterized by a high genetic variability. SRLVs infection may result in a variety of clinical signs in goats and sheep and is not species-specific.
Paola Gobbi, Paola Gobbi, Luca Tassoni, Elena Tinelli, Eleonora Scoccia, Sara Mrabet, Mario Orrico, Cecilia Righi, Carmen Maresca, Nicoletta D’Avino, Fabrizio Passamonti, Monica Giammarioli, Francesco Feliziani, Maria Serena Beato   +13 more
doaj   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source