Results 41 to 50 of about 84,233 (235)
Clinical and Developmental Immunology, 2012 Highly active antiretroviral therapy has dramatically improved the morbidity and mortality of HIV-1-infected individuals. A total of 25 licensed drugs provide the basis for an optimized virus-suppressive treatment of nearly each subject.
Moritz Ries +2 more
doaj +1 more source
Leukocytosis and Expression of Bovine Leukemia Virus microRNAs in Cattle
Frontiers in Veterinary Science, 2020 Bovine Leukemia Virus (BLV) is an established model for studying retroviral infections, in particular the infection by the human T-cell leukemia type 1 (HTLV-1) virus.
Gleb Yu. Kosovsky +6 more
doaj +1 more source
Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses
Frontiers in Immunology, 2018 About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements ...
Nicole Grandi, E. Tramontano
semanticscholar +1 more source
It’s the Little Things (in Viral RNA)
mBio, 2020 Chemical modifications of viral RNA are an integral part of the viral life cycle and are present in most classes of viruses. To date, more than 170 RNA modifications have been discovered in all types of cellular RNA.
Jiří František Potužník +1 more
doaj +1 more source
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses
Nature Medicine, 2018 Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1–4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5–8, but remains incompletely ...
I. Canadas +37 more
semanticscholar +1 more source
Nuclear Trafficking of Retroviral RNAs and Gag Proteins during Late Steps of Replication
Viruses, 2013 Retroviruses exploit nuclear trafficking machinery at several distinct stages in their replication cycles. In this review, we will focus primarily on nucleocytoplasmic trafficking events that occur after the completion of reverse transcription and ...
Matthew S. Stake +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Role of Lipids in Retrovirus Replication
Viruses, 2010 Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell.
Abdul A. Waheed, Eric O. Freed
doaj +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Cross- and Co-Packaging of Retroviral RNAs and Their Consequences
Viruses, 2016 Retroviruses belong to the family Retroviridae and are ribonucleoprotein (RNP) particles that contain a dimeric RNA genome. Retroviral particle assembly is a complex process, and how the virus is able to recognize and specifically capture the genomic RNA
Lizna M. Ali +2 more
doaj +1 more source