Results 111 to 120 of about 7,238 (191)

Sex‐Specific Factors Influencing HIV Infection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Immune responses are key in controlling viral infections such as HIV‐1, which remains a global challenge to public health. X/Y‐chromosome‐encoded genes and sex steroid hormones can modulate immune cells and drive distinct patterns of gene and protein expression involved in antiviral function, impacting sex‐dependent immune responses and ...
Maria Pujantell, Marcus Altfeld
wiley   +1 more source

Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function. [PDF]

, 2013
Why do we need to sleep? What regulates when we sleep? And what dictates the number of hours we require? These are often viewed as three separate biological questions.
Chong, SY Christin, Fu, Ying-Hui, Kurien, Philip A, Ptáček, Louis J   +3 more
core   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, Volume 36, Issue 10, 2 February 2026.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Altered sleep homeostasis in rev-erbα knockout mice [PDF]

, 2016
Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive transcriptional repressor critical for the regulation of key circadian and metabolic genes.
Albrecht, Urs, Chappuis, Sylvie, Emmenegger, Yann, Franken, Paul, La Spada, Francesco, Mang, Géraldine M., Ripperger, Jürgen A.   +6 more
core   +1 more source

Nuclear receptor protein: REV-ERB

Northern Clinics of Istanbul
REV-ERB α/β proteins play critical roles in circadian rhythm regulation and are considered to be specialized members of the nuclear receptor family. These so-called "orphan" proteins, whose endogenous ligands were initially unidentified, have become exogenously interferable through synthetic agents with the discovery of their endogenous ligands.
openaire   +2 more sources

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

P19 Cells as a Model for Studying the Circadian Clock in Stem Cells before and after Cell Differentiation

Journal of Circadian Rhythms, 2018
In mammals, circadian rhythmicity is sustained via a transcriptional/translational feedback loop referred to as the canonical molecular circadian clock.
Abdullah Mashhour, Zainab Al Mansour, Al Shaima Al Hallaj, Rizwan Ali, Thadeo Trivilegio, Mohamed Boudjelal   +5 more
doaj   +1 more source

Probabilistic Modeling for Prediction Errors to Enhance Balancing Market Participation of Photovoltaic Systems: Error Threshold Estimation, Multisite Aggregation, and Overloading Effects

Advanced Energy and Sustainability Research, Volume 7, Issue 2, February 2026.
This study proposes a method to increase the value of solar power in balancing markets by managing prediction errors. The approach models prediction uncertainties and quantifies reserve requirements based on a probabilistic model. This enables the more reliable participation of photovoltaic plants in balancing markets across multiple sites, especially ...
Jindan Cui, Xue Fang, Takashi Oozeki, Yuzuru Ueda   +3 more
wiley   +1 more source

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML [PDF]

, 2018
Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies.
Al-Shahrour, Fatima, Chen, Michelle C., Cowley, Glenn S., de Boer, Carl G., Ebert, Benjamin L., Heckl, Dirk, Järås, Marcus, Kowalczyk, Monika S., Li, Hubo, McConkey, Marie, Miller, Peter G., Puram, Rishi V., Regev, Aviv, Rozenblatt-Rosen, Orit, Schneider, Rebekka K., Tamayo, Alfred, Tejero, Héctor, Tothova, Zuzana   +17 more
core   +1 more source

DEC2 modulates orexin expression and regulates sleep. [PDF]

, 2018
Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait.
Fu, Ying-Hui, Hirano, Arisa, Hsu, Pei-Ken, McMahon, Thomas, Ptáček, Louis J, Xing, Lijuan, Yamazaki, Maya, Zhang, Luoying   +7 more
core   +1 more source