Results 101 to 110 of about 6,288,081 (333)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Neonatal Hypoxic-Ischemic Encephalopathy Yields Permanent Deficits in Learning Acquisition: A Preclinical Touchscreen Assessment

Frontiers in Pediatrics, 2020
Neonatal hypoxic-ischemic encephalopathy (HIE) remains a common problem world-wide for infants born at term. The impact of HIE on long-term outcomes, especially into adulthood, is not well-described.
Jessie R. Maxwell, Jessie R. Maxwell, Amber J. Zimmerman, Nathaniel Pavlik, Jessie C. Newville, Katherine Carlin, Shenandoah Robinson, Jonathan L. Brigman, Frances J. Northington, Lauren L. Jantzie, Lauren L. Jantzie, Lauren L. Jantzie   +11 more
doaj   +1 more source

Domain-Adversarial Training of Neural Networks

, 2016
We introduce a new representation learning approach for domain adaptation, in which data at training and test time come from similar but different distributions.
Ajakan, Hana, Ganin, Yaroslav, Germain, Pascal, Larochelle, Hugo, Laviolette, François, Lempitsky, Victor, Marchand, Mario, Ustinova, Evgeniya   +7 more
core   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Subcortical Dopamine and Cognition in Schizophrenia: Looking Beyond Psychosis in Preclinical Models

Frontiers in Neuroscience, 2020
Schizophrenia is characterized by positive, negative and cognitive symptoms. All current antipsychotic treatments feature dopamine-receptor antagonism that is relatively effective at addressing the psychotic (positive) symptoms of schizophrenia. However,
Kyna-Anne Conn, Thomas H. J. Burne, Thomas H. J. Burne, James P. Kesby, James P. Kesby   +4 more
doaj   +1 more source

The motivating operation and negatively reinforced problem behavior. A systematic review. [PDF]

, 2014
The concept of motivational operations exerts an increasing influence on the understanding and assessment of problem behavior in people with intellectual and developmental disability. In this systematic review of 59 methodologically robust studies of the
Borthwick-Duffy S. A., Carey Y. A., Edrisinha C. E., Kennedy C. H., Miltenberger R. G., Oliver C., Rusch R. G., Scotti J. R.   +7 more
core   +1 more source

Cognition in the field: comparison of reversal learning performance in captive and wild passerines

Scientific Reports, 2017
Animal cognitive abilities have traditionally been studied in the lab, but studying cognition in nature could provide several benefits including reduced stress and reduced impact on life-history traits.
M. Cauchoix, E. Hermer, A. Chaine, A. Chaine, J. Morand‐Ferron   +4 more
semanticscholar   +1 more source

The association of physical function with psychosocial patient‐reported outcomes in people with systemic lupus erythematosus

Arthritis Care &Research, Accepted Article.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts [Approaches to Positive, Patient‐centered Experiences of Aging with Lupus (APPEAL) and California Lupus Epidemiology Study
Mrinalini Dey, Jessica Fitzpatrick, Maria Dall'Era, Charmayne Dunlop‐Thomas, Courtney Hoge, S. Sam Lim, Patricia P. Katz, Jinoos Yazdany, Laura C. Plantinga   +8 more
wiley   +1 more source

Role of Reversal Learning Impairment in Social Disinhibition following Severe Traumatic Brain Injury [PDF]

, 2016
OBJECTIVES: The current study aimed to determine whether reversal learning impairments and feedback-related negativity (FRN), reflecting reward prediction error signals generated by negative feedback during the reversal learning tasks, were associated ...
McDonald, S, Osborne-Crowley, K, Rushby, JA   +2 more
core   +1 more source

Successive Olfactory Reversal Learning in Honeybees [PDF]

Learning & Memory, 2002
HoneybeesApis melliferacan associate an originally neutral odor with a reinforcement of sucrose solution. Forward pairings of odor and reinforcement enable the odor to release the proboscis extension reflex in consecutive tests. Bees can also be conditioned differentially: They learn to respond to a reinforced odor and not to a nonreinforced one.
Bernhard, Komischke, Martin, Giurfa, Harald, Lachnit, Dagmar, Malun   +3 more
openaire   +2 more sources