Results 71 to 80 of about 5,958,314 (335)
Cerebral Cortex, 2019 Much evidence suggests that reversal learning is mediated by cortico-striatal circuitries with the orbitofrontal cortex (OFC) playing a prominent role. The OFC is a functionally heterogeneous region, but potential differential roles of lateral (lOFC) and
M. E. Hervig +8 more
semanticscholar +1 more source
Determining a Role for Ventromedial Prefrontal Cortex in Encoding Action-Based Value Signals During Reward-Related Decision Making [PDF]
, 2009 Considerable evidence has emerged to implicate ventromedial prefrontal cortex in encoding expectations of future reward during value-based decision making.
Alan N. Hampton +53 more
core +3 more sources
Learning to find spatially reversed sounds [PDF]
Scientific Reports, 2020 AbstractAdaptation to systematic visual distortions is well-documented but there is little evidence of similar adaptation to radical changes in audition. We use a pseudophone to transpose the sound streams arriving at the left and right ears, evaluating the perceptual effects it provokes and the possibility of learning to locate sounds in the reversed ...
Fernando Bermejo +4 more
openaire +3 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Antidepressant suppression of REM and spindle sleep impairs hippocampus-dependent learning and memory but fosters striatal-dependent strategies [PDF]
, 2011 REM sleep enhances hippocampus-dependent associative memory but has little impact on striatal-dependent procedural learning. Antidepressant medications like desipramine (DMI) inhibit rapid-eye-movement (REM) sleep but it is little understood how ...
Alain Watts +3 more
core +1 more source
Threat rapidly discrupts Reward Reversal Learning
Behaviour Research and Therapy, 2019 Threat changes cognition to facilitate adaptive coping. However, when threat becomes overwhelming, this may be deleterious for mental health especially in vulnerable individuals. Flexible decision-making was probed with a reward reversal task to investigate, how well healthy participants (N=34) can adapt to changes in reward contingency when they ...
Christian Paret, Florian Bublatzky
openaire +4 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2015 In reversal learning, subjects first learn to respond to a reinforced stimulus A and not to a non-reinforced stimulus B (A+ vs. B-) and then have to learn the opposite when stimulus contingencies are reversed (A- vs. B+).
Constance eBoitard +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source