Results 81 to 90 of about 5,958,314 (335)

An associative account of collective learning

Royal Society Open Science
Associative learning is an important adaptive mechanism that is well conserved among a broad range of species. Although it is typically studied in isolated animals, associative learning can occur in the presence of conspecifics in nature.
Matthew Gildea, Cristina Santos, Federico Sanabria, Takao Sasaki   +3 more
doaj   +1 more source

Touchscreen-based Visual Discrimination and Reversal Tasks for Mice to Test Cognitive Flexibility

Bio-Protocol, 2017
Reversal learning can be used to examine deficits in cognitive flexibility, which have been linked to a number of neuropsychiatric disorders including schizophrenia and addiction.
Karly Turner, Christopher Simpson, Thomas H. J. Burne   +2 more
doaj   +1 more source

Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty. [PDF]

, 2019
The subjective sense of certainty, or confidence, in ambiguous sensory cues can alter the interpretation of reward feedback and facilitate learning. We trained rats to report the orientation of ambiguous visual stimuli according to a spatial stimulus ...
Hart, EE, Izquierdo, A, Lau, H, O'Dell, TJ, Peters, MAK, Rakhshan, M, Soltani, A, Stolyarova, A   +7 more
core   +1 more source

Learning reversible symplectic dynamics

, 2022
Time-reversal symmetry arises naturally as a structural property in many dynamical systems of interest. While the importance of hard-wiring symmetry is increasingly recognized in machine learning, to date this has eluded time-reversibility. In this paper we propose a new neural network architecture for learning time-reversible dynamical systems from ...
Valperga, R, Webster, K, Klein, V, Turaev, D, Lamb, JSW   +4 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Reward prediction error in learning-related behaviors

Frontiers in Neuroscience, 2023
Learning is a complex process, during which our opinions and decisions are easily changed due to unexpected information. But the neural mechanism underlying revision and correction during the learning process remains unclear.
Yujun Deng, Da Song, Junjun Ni, Hong Qing, Hong Qing, Zhenzhen Quan   +5 more
doaj   +1 more source

Sex differences in color discrimination and serial reversal learning in mollies and guppies

Current Zoology, 2019
Behavioral flexibility provides an individual with the ability to adapt its behavior in response to environmental changes. Studies on mammals, birds, and teleosts indicate greater behavioral flexibility in females.
T. Fuss, K. Witte
semanticscholar   +1 more source

Reverse generative learning

Journal of International Students
This paper examines the impact of senior influencers on Douyin and their role in shaping the educational perceptions of postgraduate students in mainland China. The paper comprises 23 semistructured interviews with students in Guangdong, exploring three themes: algorithm-driven intergenerational identity fluidity, the decentralization of knowledge ...
Wenrui Liang, Rosya Izyanie Shamshudeen, Md Azalanshah Md Syed, Shen Hui   +3 more
openaire   +1 more source