Results 51 to 60 of about 113,812 (280)
Putting cholesterol in its place: apoE and reverse cholesterol transport [PDF]
Journal of Clinical Investigation, 2006 To avoid toxic overload of cholesterol in peripheral cells, the reverse cholesterol transport pathway directs excess cholesterol through HDL acceptors to the liver for elimination. In this issue of the JCI, a study by Matsuura et al. reveals new features of this pathway, including the importance of the ATP-binding cassette transporter G1 in macrophages
Karl H. Weisgraber +2 more
openaire +3 more sources
Advanced Biology, EarlyView.The successful in situ polymerization of microtubules in giant polymer‐lipid hybrid vesicles is illustrated. The microtubules formed in the giant hybrid vesicles exhibit different morphologies including lumenal network formation and membrane association. Abstract Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a
Paula De Dios Andres +4 more
wiley +1 more source
Spatially Resolving the Condensing Effect of Cholesterol in Lipid Bilayers [PDF]
, 2018 We study the effect of cholesterol on the structure of dipalmitoylphosphatidylcholine (DPPC) phospholipid bilayers. Using extensive molecular dynamics computer simulations at atomistic resolution we observe and quantify several structural changes upon increasing cholesterol content that are collectively known as the condensing effect: a thickening of ...
arxiv +1 more source
Lateral phase separation in mixtures of lipids and cholesterol systems [PDF]
Europhys. Lett. 67, 321 (2004), 2004 In an effort to understand ``rafts'' in biological membranes, we propose phenomenological models for saturated and unsaturated lipid mixtures, and lipid-cholesterol mixtures. We consider simple couplings between the local composition and internal membrane structure, and their influence on transitions between liquid and ``gel'' membrane phases. Assuming
arxiv +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Journal of Lipid Research, 2010 Previous studies have shown that cholesterol in atherosclerotic plaques is present in both intracellular and extracellular forms. In the current study, we investigated a mechanism for extracellular cholesterol accumulation and examined the capacity of ...
Daniel S. Ong +5 more
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Frontiers in Physiology, 2018 Dyslipidemia (high concentrations of LDL-c and low concentrations of HDL-c) is a major cause of cardiovascular events, which are the leading cause of death in the world.
Leandro R. Marques +6 more
doaj +1 more source
Induction of obesity impairs reverse cholesterol transport in ob/ob mice. [PDF]
PLoS ONE, 2018 OBJECTIVES:Obesity is an independent risk factor for cardiovascular disease. Reverse cholesterol transport (RCT) is an important cardioprotective mechanism. This study aimed to investigate RCT changes in a murine model of obesity.
MyNgan Duong +4 more
doaj +1 more source
The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology, EarlyView.The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang +5 more
wiley +1 more source
Journal of Functional Foods, 2017 The purpose of this study was to investigate whether persimmon tannin is associated with cholesterol efflux and macrophage-reverse cholesterol transport (RCT).
Zhenzhen Ge +5 more
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