Results 111 to 120 of about 1,799,385 (351)

Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity

Molecules, 2015
Ipecac alkaloids are secondary metabolites produced in the medicinal plant Psychotria ipecacuanha. Emetine is the main alkaloid of ipecac and one of the active compounds in syrup of Ipecac with emetic property. Here we evaluated emetine’s potential as an
A. Valadão, C. Abreu, Juliana Zanatta Dias, P. Arantes, H. Verli, A. Tanuri, R. S. de Aguiar   +6 more
semanticscholar   +1 more source

Telomerase reverse transcriptase activity.

, 2013
Telomerase reverse transcriptase activity.
Renza Spelat (293251), Antonio Paolo Beltrami (298852), Federico Ferro (298850), Francesco Curcio (293249), Daniela Cesselli (298854)   +4 more
core   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Reverse Transcriptase Jumps and Gaps

Journal of General Virology, 1996
Introduction. Retroviruses are single-stranded RNA viruses of eukaryotes. Different subfamilies have been described. Avian or murine oncoviruses induce neoplasms, whereas lentiviruses, typified by human immunodeficiency virus and spumaviruses, produce persistent infections.
J J, Kupiec, P, Sonigo
openaire   +2 more sources

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Drogas anti-VIH: passado, presente e perspectivas futuras Drugs anti-HIV: past, present and future perspectives

Química Nova, 2003
Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs).
Marcus Vinícius Nora de Souza, Mauro Vieira de Almeida   +1 more
doaj   +1 more source

Mass‐Produced and High‐Performance Nanowell Biosensor Fabricated via Semiconductor Manufacturing for Rapid and Accurate COVID‐19 Diagnosis in the Clinical Field

Advanced Science, EarlyView.
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park, Zahra Rezaei, Nam Ho Bae, Donggee Rho, Da‐Seul Kim, EunYoung Go, YoungTae Seo, Seok Jae Lee, Won Chan Seo, Luke P. Lee, HeaYeon Lee, Su Ryon Shin   +11 more
wiley   +1 more source

Full-Length cDNA Synthesis for Long-Distance RT-PCR of Large mRNA Transcripts

BioTechniques, 2003
Reverse transcription of mRNA often leads to the synthesis of partial, non-fulllength cDNAs. Methods to facilitate reverse transcription across RNA regions of secondary structure, as well as enzyme modifications to eliminate RNase H activities inherent ...
Phillip R. Hawkins, Pei Jin, Glenn K. Fu
doaj   +1 more source

Combined analysis of Two-Year Follow-up from two open-label randomized trials comparing efficacy of three nucleoside reverse transcriptase inhibitor backbones for previously untreated HIV-1 nfection: OzCombo 1 and 2

, 2003
Purpose: To compare inhibition of HIV replication, improvements in CD4+ T-cell counts, metabolic parameters, and body shape changes after 2 years of assigned therapy in OzCombo patients.
Cooper, D.A., Todhunter, L., Sowden, D., Hoy, J.N., Papanaoum, K., Quin, J., Genn, W., Amin, J., Mulholland, J., Bryant, M., Shaw, D.V., Ferguson, W., Baker, D., Moore, A., Scull, N., James, R., French, M.A., Street, A., Packham, D., Foreman, E., Doong, N.C., Rawlinsen, M., McCormack, C., Norrito, L., Dwyer, D., Quan, D., Roney, J., Waddell, R., French, M.R., Carr, A., De Graaf, B., Garsia, R., Law, M., Beveridge, A., Kotsiou, G., Fordham, M., Emery, S., Rebic, D., Mallal, S.   +38 more
core  

Reverse transcriptase

, 2023
Bakalářská práce je zaměřena na reverzní transkriptázu. Na úvodu jsou popsány nukleové kyseliny. Následně se práce zabývá centrálním dogmatem a reverzní transkripcí. Nejvíce se práce věnuje využití reverzní transkriptázy v molekulární biologii, konkrétně
Kuryviálová, Ivana
core