Results 141 to 150 of about 382,156 (284)

E138A in HIV-1 reverse transcriptase is more common in subtype C than B: Implications for rilpivirine use in resource-limited settings

, 2014
Nicolas Sluis‐Cremer, Michael R. Jordan, Kelly Huber, Carole L. Wallis, Silvia Bertagnolio, John W. Mellors, Neil Parkin, P. Richard Harrigan   +7 more
openalex   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Molecular mechanism of the type 2 defense-associated reverse transcriptase. [PDF]

Nucleic Acids Res
Liu Z, Liao F, Wu W, Zhang C, Yue C, Chen A, Zhang S, Liu Y, Liu B, Han J, Zhang C, Wang X, Li X, Li Z, Zhang H, Yin H.   +15 more
europepmc   +1 more source

Nanogel-Conjugated Reverse Transcriptase Inhibitors and Their Combinations as Novel Antiviral Agents with Increased Efficacy against HIV-1 Infection

, 2015
Thulani H. Senanayake, Santhi Gorantla, Edward Makarov, Yaman Lu, Galya Warren, С. В. Виноградов   +5 more
openalex   +1 more source

Microgel‐Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction

Advanced Science, EarlyView.
This study develops a hierarchically porous hydrogel patch strategy (HPMP), based on gas‐shearing microfluidics and an aqueous two‐phase system to fabricate porous microgels as microgel‐based bioinks. The porous microgels with controllable porous structure exhibit excellent cellular behavior.
Ziyang Liu, Leyan Xuan, Yingying Hou, Ting Xie, Jieting Li, Junjie Cai, Siyu Zhang, Yingling Miao, Ning Hou, Gen He, Maobin Xie, Xiyong Yu, Mingen Xu, Guosheng Tang   +13 more
wiley   +1 more source

Approaches to repurposing reverse transcriptase antivirals in cancer. [PDF]

Br J Clin Pharmacol
Head R, Islam S, Martin JH.
europepmc   +1 more source

Murine leukemia virus pol gene products: analysis with antisera generated against reverse transcriptase and endonuclease fusion proteins expressed in Escherichia coli [PDF]

, 1986
S C Hu, Donald L. Court, M Zweig, Judith G. Levin   +3 more
openalex   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design. [PDF]

Acta Pharm Sin B
Zhou Z, Sun Y, Feng D, Wang Z, Zhao F, Gao S, Zhan P, Kang D, Liu X.   +8 more
europepmc   +1 more source