Results 171 to 180 of about 382,156 (284)

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

Anti-phage defense mechanism involving phage-encoded DNA binding protein and bacterial reverse transcriptase DRT4. [PDF]

Nat Commun
Wang Y, Wu H, Li J, An Q, Tian Z, Deng Z.   +5 more
europepmc   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. [PDF]

World J Gastrointest Oncol
Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T.   +10 more
europepmc   +1 more source

A Novel Tricomplex of BRCA1, Nmi, and c-Myc Inhibits c-Myc-induced Human Telomerase Reverse Transcriptase Gene (hTERT) Promoter Activity in Breast Cancer [PDF]

, 2002
Huchun Li, Taehee Lee, Hava Avraham
openalex   +1 more source

Engineering a Thermostable Reverse Transcriptase for RT-PCR Through Rational Design of <i>Pyrococcus furiosus</i> DNA Polymerase. [PDF]

Biomolecules
Kuznetsova AA, Grishina IA, Mikushina ES, Kuznetsov NA.   +3 more
europepmc   +1 more source

Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population

, 2019
Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Sandeep Kumar Parvathareddy, Nabil Siraj, Sarah Siraj, Mark Diaz, Dionne Rala, Allianah Benito, Maria A. Sabido, Maha Al‐Rasheed, Khadija A.S. Al‐Obaisi, Wael Al‐Haqawi, Ingrid G. Victoria, Wafaa Al Balawy, Malak Abedalthagafi, Salma M. Wakil, Dahish Ajarim, Shamayel Mohammed, Turki Al‐Hussain, Asma Tulbah, Ismail A. Al‐Badawi, Fouad Al‐Dayel, Khawla S. Al‐Kuraya   +23 more
openalex   +1 more source

Inhibition of long interspersed nuclear element-1 by nucleoside reverse transcriptase inhibitors attenuates vascular calcification. [PDF]

Signal Transduct Target Ther
Ma J, He D, Zhang M, Zhou Z, Cheng J, Huang A, Lian Y, Shi Y, Xie C, Guan Z, Zhang Z, Xie C, Zhang T, Huang H.   +13 more
europepmc   +1 more source

Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. [PDF]

Bioorg Med Chem Lett
Frost GB, Liu Y, Kron SJ, Scheidt KA.
europepmc   +1 more source

Magnesium Functions as Superior Co-factor for Measuring Reverse Transcriptase Activity of HIV-1, HIV-2, and SIV

, 2020
Salequl Islam, Mohammad Ali Moni, Atsushi Tanaka, Hiroo Hoshino   +3 more
openalex   +2 more sources