Results 191 to 200 of about 965,759 (306)

Tenofovir diphosphate intracellular concentration following tenofovir alafenamide administration in bictegravir‐containing vs. dolutegravir‐containing antiretroviral regimens

British Journal of Clinical Pharmacology, EarlyView.
This study investigates intracellular (IC) exposure of tenofovir alafenamide (TAF) and its clinical determinants in experienced people living with HIV. We conducted a monocentric retrospective analysis of 86 adults treated with either bictegravir (BIC)‐ or dolutegravir (DTG)‐containing regimen. Plasma and IC trough concentrations (Ctrough) of tenofovir
Micol Ferrara, Viviana Maccario, Silvia Fantino, Erica Clemente, Federica Barrera, Alice Palermiti, Sara Soloperto, Amedeo De Nicolo, Antonio D'Avolio, Giovanni Di Perri, Stefano Bonora   +10 more
wiley   +1 more source

The Telomerase Reverse Transcriptase (TERT) Gene Molecular Characterization in Sheep and the Association of Its Variation with Wool Traits. [PDF]

Animals (Basel)
Zhao F, He Z, Zhou H, Sun H, Ma L, Chen Z, Wei L, Li S.   +7 more
europepmc   +1 more source

Reverse Transcriptase Connection and RNase H Domain Variation in HIV-1 Subtype C Among Individuals with Virologic Failure in Botswana. [PDF]

Biomedicines
Zuze BJL, Choga WT, Moraka-Mankge NO, Maphorisa S, Mothudi M, Maruping M, Phuthego T, Mokomane M, Moyo S, Gaseitsiwe S.   +9 more
europepmc   +1 more source

From Ecological States to Trajectories: Revealing Ecological Dynamics Through Environmental Nucleic Acids

Biological Diversity, EarlyView.
Environmental nucleic acids (eNA) observations integrate temporal and ecological information across multiple dimensions of an ecological state. Repeated and complementary observations extend biomonitoring from state assessment toward reconstruction of ecological trajectories, including their direction, rate, pathways, progression, recovery, and ...
Wei Xiong, Aibin Zhan
wiley   +1 more source

A UG5 reverse transcriptase-nitrilase antiviral module confers phage immunity in the plant symbiont <i>Sinorhizobium meliloti</i>. [PDF]

Microbiol Spectr
Sánchez-Nieto E, Martínez-Abarca F, Millán V, Molina-Sánchez MD, García-Rodríguez FM, Toro N.   +5 more
europepmc   +1 more source

Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates

Chemistry – A European Journal, EarlyView.
A single‐tube protocol for enzymatic synthesis of DNA containing 1–3 site‐specific nucleobase modifications was developed based on repeated single nucleotide extension, primer extension, and exchange of template. ABSTRACT Two approaches for the enzymatic synthesis of DNA oligonucleotides (ONs) bearing multiple site‐specific modifications were explored.
Lukáš Kaiser, Veronika Raindlová, Michal Hocek   +2 more
wiley   +1 more source

Diagnostic Accuracy of Real Time Reverse Transcriptase Polymerase Chain Reaction for Chikungunya Virus Detection: A Systematic Review and Meta-Analysis. [PDF]

Trop Med Int Health
Costa RJ, Marconi CSC, Jesus GK, Franco GO, Silva AM, Arriaga MB, Soares GC, Sardi SI, Netto EM.   +8 more
europepmc   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

Natural diversity-guided catalytic-core chimerism engineers a rapid and inhibitor-tolerant reverse transcriptase. [PDF]

J Biol Eng
Fonseca Costa I, Ondina Fernandes V, Silva Simões R, Simões H, Rico Pires VM, Alves VD, Soeiro Teodoro J, Bule P, Mendes Godinho de Andrade Fontes C.   +8 more
europepmc   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source