Results 11 to 20 of about 1,758,180 (373)

Computational development of rubromycin-based lead compounds for HIV-1 reverse transcriptase inhibition [PDF]

PeerJ, 2014
The binding of several rubromycin-based ligands to HIV1-reverse transcriptase was analyzed using molecular docking and molecular dynamics simulations. MM-PBSA analysis and examination of the trajectories allowed the identification of several promising ...
Carlos E.P. Bernardo, Pedro J. Silva
doaj   +6 more sources

Relevance of micrometastases detected by reverse transcriptase-polymerase chain reaction for melanoma recurrence: systematic review and meta-analysis [PDF]

São Paulo Medical Journal, 2003
CONTEXT: Cutaneous melanoma presents significant morbidity and mortality. Nowadays, about 90% of them are diagnosed by clinical examination and most are localized melanomas.
Allisson Monteiro da Silva, Renato Santos de Oliveira Filho, Lydia Masako Ferreira, Humberto Saconato   +3 more
doaj   +3 more sources

Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009) [PDF]

, 2013
Background:A major concern with using antiretroviral (ARV)-based products for HIV prevention is the potential spread of drug resistance, particularly from individuals who are HIV-infected but unaware of their status.
Barbara Mensch, Cliff Kelly, Gita Ramjee, John W. Mellors, Kailazarid Gomez, Krista Eskay, Lydia Soto-Torres, on behalf of the IPTc Taskforce, Pamina Gorbach, Photini Kiepiela, Shayhana Ganesh, Stephanie Horn, Urvi M. Parikh   +12 more
core   +19 more sources

Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction–Based SARS-CoV-2 Tests by Time Since Exposure

Annals of Internal Medicine, 2020
Background: Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to “rule out” infection among high-risk persons, such as exposed inpatients and health ...
L. Kucirka, S. Lauer, O. Laeyendecker, D. Boon, J. Lessler   +4 more
semanticscholar   +1 more source

Diagnostic Performance of CT and Reverse Transcriptase-Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis

Radiology, 2020
Background Recent studies have suggested that chest computed tomography (CT) scans could be used as a primary screening or diagnostic tool for coronavirus disease 2019 (COVID-19) in epidemic areas.
Hyungjin Kim, Hyunsook Hong, S. Yoon
semanticscholar   +1 more source

Viral reverse transcriptases [PDF]

Virus Research, 2017
Reverse transcriptases (RTs) play a major role in the replication of Retroviridae, Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are able to synthesize DNA using RNA or DNA as templates (DNA polymerase activity), and degrade RNA when forming RNA/DNA hybrids (ribonuclease H activity).
Menéndez-Arias, Luis, Sebastián-Martín, Alba, Álvarez, Mar   +2 more
openaire   +3 more sources

False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases

Korean Journal of Radiology, 2020
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide.
Dasheng Li, Dawei Wang, Jianping Dong, Nan Wang, He Huang, Haiwang Xu, Chen Xia   +6 more
semanticscholar   +1 more source

Sensitivity and Specificity of High Resolution Computed Tomography Chest in Diagnosing Corona Virus Disease 2019: A Retrospective Correlation with Reverse Transcriptase Polymerase Chain Reaction

Journal of Nobel Medical College, 2022
Background: Corona Virus Disease 2019came into existence in December 2019, as a sudden outbreak inthe city of Wuhan, China. Early identification of the patient is vitalto control disease transmission.This study is aimed at estimatingthe sensitivity ...
Robinson Shrestha, Mahesh Gautam
doaj   +1 more source

Telomerase reverse transcriptase and neurodegenerative diseases

Frontiers in Immunology, 2023
Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS).
Xin Yu, Meng-Meng Liu, Cai-Yun Zheng, Yu-Tong Liu, Zhuo Wang, Zhan-You Wang   +5 more
doaj   +1 more source

Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3

Viruses, 2017
Converting the single-stranded retroviral RNA into integration-competent double-stranded DNA is achieved through a multi-step process mediated by the virus-coded reverse transcriptase (RT).
Jason W. Rausch, Jennifer T. Miller, Stuart F. J. Le Grice   +2 more
doaj   +1 more source