Results 251 to 260 of about 965,759 (306)
Some of the next articles are maybe not open access.
Biochemical and Biophysical Research Communications, 1974
Summary Purified DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was analyzed for zinc by atomic absorption spectroscopy. Tightly bound zinc was present in a stoichiometry approximating 1 gm atom/mole of enzyme. Inhibition by the chelating agent, ortho -phenanthroline, and lack of inhibition by its non-chelating analog ...
B J, Poiesz, N, Battula, L A, Loeb
openaire +2 more sources
Summary Purified DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was analyzed for zinc by atomic absorption spectroscopy. Tightly bound zinc was present in a stoichiometry approximating 1 gm atom/mole of enzyme. Inhibition by the chelating agent, ortho -phenanthroline, and lack of inhibition by its non-chelating analog ...
B J, Poiesz, N, Battula, L A, Loeb
openaire +2 more sources
Retroviral reverse transcriptases
Cellular and Molecular Life Sciences, 2010Reverse transcription is a critical step in the life cycle of all retroviruses and related retrotransposons. This complex process is performed exclusively by the retroviral reverse transcriptase (RT) enzyme that converts the viral single-stranded RNA into integration-competent double-stranded DNA.
Alon, Herschhorn, Amnon, Hizi
openaire +2 more sources
The Discovery of Reverse Transcriptase
Annual Review of Virology, 2016In 1970 the independent and simultaneous discovery of reverse transcriptase in retroviruses (then RNA tumor viruses) by David Baltimore and Howard Temin revolutionized molecular biology and laid the foundations for retrovirology and cancer biology. In this historical review we describe the formulation of the controversial provirus hypothesis by Temin ...
John M, Coffin, Hung, Fan
openaire +2 more sources
Reverse transcriptase in bacteria
Molecular Microbiology, 1989Summary Reverse transcriptase, discovered in 1970 in retroviruses, has until recently been found only in eukaryotic organisms. Recently it was shown to occur in two groups of bacteria: myxobacteria and Escherichia coli.
D, Lim, W K, Maas
openaire +2 more sources
Reverse Transcriptase Inhibitors as Microbicides
Current HIV Research, 2012The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing antiretrovirals that target specific enzymes in the reproduction cycle of HIV, especially reverse transcriptase inhibitors (RTI). In this review we discuss the potential relevance of HIV-1 RTIs as microbicides, focusing in the nucleotide ...
Lewi, P. +7 more
openaire +3 more sources
Bacterial reverse transcriptase and msDNA
Virus Genes, 1995Retrons are a new class of genetic elements found in the chromosome of a large number of different bacteria. These elements code for a reverse transcriptase (RT) that is structurally similar to the polymerases of retroviruses. The retron associated RT is responsible for the production of an unusual extrachromosomal satellite DNA, known as multicopy ...
S A, Rice, B C, Lampson
openaire +2 more sources
Discovery of the reverse transcriptase.
The FASEB Journal, 19951995 is the 20th anniversity of the award of the Nobel Prize in Physiology or Medicine to David Baltimore and Howard Temin for the discovery of the reverse transcriptase. The prize was shared with Renato Dulbecco.
openaire +3 more sources
Biochemical Education, 1995
Abstract The reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) converts the single-stranded (+) viral RNA genome into double¬ stranded proviral DNA prior to its integration into the host genomic DNA. The HIV-1 RT has therefore been the target for anti-viral drug design (1). The cloning of the RT in biologically
W A Beard, S H Wilson
openaire +2 more sources
Abstract The reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) converts the single-stranded (+) viral RNA genome into double¬ stranded proviral DNA prior to its integration into the host genomic DNA. The HIV-1 RT has therefore been the target for anti-viral drug design (1). The cloning of the RT in biologically
W A Beard, S H Wilson
openaire +2 more sources
Retroelements, reverse transcriptase and evolution
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1995Retroelements are genetic elements that can exist as DNA or RNA or DNA/RNA duplexes. Although retroviruses are the best known retroelements, there are many other types, including close relatives of retroviruses like LTR retrotransposons, more distant relatives like non-LTR retrotransposons, caulimoviruses and hepadnaviruses and elements with virtually ...
openaire +2 more sources
Group II Intron-Like Reverse Transcriptases Function in Double-Strand Break Repair
Cell, 2022Alan M. Lambowitz +2 more
exaly