Results 231 to 240 of about 965,759 (306)

Spinal low-grade ependymal tumors harboring telomerase reverse transcriptase promoter mutation and chromosome 7 gain with methylation profile of spinal subependymoma. [PDF]

Acta Neuropathol Commun
Nagashima Y, Yamaguchi J, Nishimura Y, Seki M, Yamada S, Maeda S, Tsukamoto E, Yamamoto R, Takido Y, Kimura K, Ohka F, Karube K, Saito R.   +12 more
europepmc   +1 more source

Hepatic Adenomas in Men: Diagnostic Considerations and Management in the Modern Era

Journal of Surgical Oncology, EarlyView.
ABSTRACT Hepatic adenomas (HAs) are rare benign liver tumors traditionally associated with young women, yet contemporary epidemiologic trends reveal increasing recognition among men. Historically, universal resection in males has been recommended because of a nearly tenfold increased risk of malignant transformation as reported by Farges et al.
Teresa Belledent, Julie Nwosu, Kiers Brevik, Raegen M. Abbey, Timothy Pawlik, Dae Sun Hwang, Terry L. Hayes, Ikenna Nwosu, Mohammed O. Suraju, Hassan Aziz   +9 more
wiley   +1 more source

Reverse transcriptase inhibitors enable the generation of fertile spermatids from fetal mouse testes in vitro. [PDF]

Commun Biol
Nishida M, Ono-Sunagare Y, Kato S, Ishikawa-Yamauchi Y, Matsumura T, Komeya M, Matoba S, Inoue K, Ogonuki N, Ogura A, Ogawa T, Sato T.   +11 more
europepmc   +1 more source

Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng, Yen‐Hsien Wu, Yi‐Ching Liu, I‐Chen Chen, Chung‐Yu Yeh, Shang‐En Huang, Ren‐Long Jan, Jwu‐Lai Yeh, Jong‐Hau Hsu   +8 more
wiley   +1 more source

Structural basis of antiphage defence by an ATPase-associated reverse transcriptase. [PDF]

Nat Commun
George JT, Burman N, Wilkinson RA, de Silva S, McKelvey-Pham Q, Buyukyoruk M, Dale A, Landman H, Graham AB, DeLuca SZ, Wiedenheft B.   +10 more
europepmc   +1 more source

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

Exploring the Role of Leukocyte Telomere Length and Human Telomerase Reverse Transcriptase MNS16A Variant in Cannabis or Synthetic Cannabinoid Use Disorder. [PDF]

Clin Psychopharmacol Neurosci
Pehlivan S, Nursal AF, Aytac HM, Oyaci Y, Aytac E, Pehlivan M.   +5 more
europepmc   +1 more source

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design. [PDF]

Acta Pharm Sin B
Zhou Z, Sun Y, Feng D, Wang Z, Zhao F, Gao S, Zhan P, Kang D, Liu X.   +8 more
europepmc   +1 more source

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

The Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano, Satoshi Kiyama, Takayuki Kyutoku, Masaru Yamashita   +3 more
wiley   +1 more source