Results 241 to 250 of about 1,799,385 (351)

Inhibition of long interspersed nuclear element-1 by nucleoside reverse transcriptase inhibitors attenuates vascular calcification. [PDF]

Signal Transduct Target Ther
Ma J, He D, Zhang M, Zhou Z, Cheng J, Huang A, Lian Y, Shi Y, Xie C, Guan Z, Zhang Z, Xie C, Zhang T, Huang H.   +13 more
europepmc   +1 more source

Origin and evolution of retroelements based upon their reverse transcriptase sequences.

EMBO Journal, 1990
Y. Xiong, T. Eickbush
semanticscholar   +1 more source

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source

MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing. [PDF]

PLoS Biol
Raheem IT, Girijavallabhan V, Fillgrove KL, Goh SL, Bahnck-Teets C, Huang Q, Li F, Wan BL, O'Donnell GT, Patteson JB, Cilento ME, Bennet A, Hayes RP, Tummala S, McHale C, Wiltsie J, Ellis J, Asante-Appiah E, Hazuda DJ, Hale J, Grobler JA, Xu M, Diamond TL, Lai MT.   +23 more
europepmc   +1 more source

Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.

European Urology, 2014
Y. Allory, Willemien Beukers, A. Sagrera, M. Flández, M. Marqués, M. Márquez, Kirstin A. van der Keur, L. Dyrskjøt, I. Lurkin, M. Vermeij, A. Carrato, J. Lloreta, J. Lorente, Enrique Carrillo-de Santa Pau, R. Masius, M. Kogevinas, E. Steyerberg, A. V. van Tilborg, C. Abas, T. Orntoft, T. Zuiverloon, N. Malats, E. Zwarthoff, F. Real   +23 more
semanticscholar   +1 more source

Andrographolide Modulates Fibrogenic and Oxidative Stress Responses in Human Lung Fibroblasts

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Pulmonary fibrosis is a progressive lung disorder characterized by fibroblast activation and excessive extracellular matrix deposition. Andrographolide (ANDRO) has been reported to attenuate pulmonary fibrosis, but the underlying molecular mechanisms remain incompletely understood.
Yu‐Hsin Tseng, Yen‐Hsien Wu, Yi‐Ching Liu, I‐Chen Chen, Chung‐Yu Yeh, Shang‐En Huang, Ren‐Long Jan, Jwu‐Lai Yeh, Jong‐Hau Hsu   +8 more
wiley   +1 more source

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells. [PDF]

MedComm (2020)
Park JH, Lee JC, Sharma S, Jiang C, Lee H, Park HJ, Kim HS.   +6 more
europepmc   +1 more source

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma

Nature Communications, 2014
Barbara Heidenreich, E. Nagore, P. S. Rachakonda, Z. García-Casado, C. Requena, V. Traves, J. Becker, N. Soufir, Kari Hemminki, Kari Hemminki, Rajiv Kumar   +10 more
semanticscholar   +1 more source

Increased expression of aromatase after focal cerebral ischemia: Relevance to neuroprotection and functional recovery

Neuroprotection, EarlyView.
Abstract Aim Aromatase is the key enzyme in the biosynthesis of 17β‐estradiol, the most potent estrogen, which has pleiotropic neuroprotective properties. Aromatase levels increase in the brain after stroke, and its gene variants increase susceptibility to stroke. This study aims to determine whether aromatase overexpression improves stroke outcome and
Lindsay Gallagher, Anna F. Dominiczak, Luis M. Garcia‐Segura, Nobuhiro Harada, J. B. Hutchison, James M. Mullin, Delyth Graham, Peter O'Shaughnessy, Hilary Victoria O. Carswell   +8 more
wiley   +1 more source

Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition. [PDF]

EMBO J
Han J, Liu B, Tang J, Zhang S, Wang X, Li X, Zhang Q, Liu Z, Wang W, Liu Y, Zhou R, Yin H, Wei Y, Li Z, Zhang M, Deng Z, Zhang H.   +16 more
europepmc   +1 more source