Results 241 to 250 of about 965,759 (306)

Switching to Daily Doravirine/Islatravir (100/0.25 mg) Maintains Viral Suppression Through Week 48 Despite Baseline Non-Nucleoside Reverse Transcriptase Inhibitor Resistance-Associated Mutations or M184I/V in Proviral DNA. [PDF]

J Infect Dis
Diamond TL, Grandhi A, Fuszard M, Xu Y, Nwoke U, Zhang Y, Klopfer SO, Eves K, Benner J, Li M, Greaves W, Lahoulou R, Kim J, Fox MC, Asante-Appiah E.   +14 more
europepmc   +1 more source

TGF‐β Inhibition Attenuates Tau Accumulation and Neurodegeneration in Progressive Supranuclear Palsy Patient‐Derived Organoids

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a devastating 4‐repeat tauopathy with no approved disease‐modifying treatments. Recent evidence showed increased transforming growth factor‐β (TGF‐β) levels in PSP patient‐derived ventral midbrain organoids (vMOs) and serum neuronally derived exosomes. Objective This study investigated whether
Mariagrazia Talarico, Andrea Quattrone, Giorgia Lucia Benedetto, Raffaele Covello, Maurizio Martini, Valeria Zuccalà, Giovanni Cuda, Elvira Immacolata Parrotta, Aldo Quattrone   +8 more
wiley   +1 more source

Lyophilised Reverse Transcriptase and Polymerase for Point-of-Care Diagnostics of SARS-CoV-2. [PDF]

Microb Biotechnol
Mutter N, Posch B, Gillitschka Y, Kataeva N, Michalek B, Lager D, Staniszewski F, Schilder A, Osinkina L, Westenthanner M, Stehr J, Buersgens F, Peham JR.   +12 more
europepmc   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Synthesis, in vitro anti-HIV-1 reverse transcriptase evaluation, molecular modelling, DFT analysis and acute oral toxicity assessment of benzotriazole derivatives. [PDF]

Sci Rep
Maiti NJ, Ganguly S, Choowongkomon K, Seetaha S, Saehlee S, Aiebchun T, Ghosh R, Khan MA, Debnath B, Nath R, Ashique S, Singh NK, Ansari MY, Tariq M, Niazi P.   +14 more
europepmc   +1 more source

Allophycocyanin inhibits HIV-1 gp120 and reverse transcriptase through enthalpy-driven binding and antioxidative protection: integrative computational and experimental insights. [PDF]

Sci Rep
Dubey A, Kumar M, Tufail A, Anand K, Sengupta S.   +4 more
europepmc   +1 more source

Protein-primed homopolymer synthesis by an antiviral reverse transcriptase. [PDF]

Nature
Tang S, Žedaveinytė R, Burman N, Pandey S, Ramirez JL, Kulber LM, Wiegand T, Wilkinson RA, Ma Y, Zhang DJ, Lampe GD, Berisa M, Jovanovic M, Wiedenheft B, Sternberg SH.   +14 more
europepmc   +1 more source

Detection of endogenous LINE-1 ORF2p and its potent reverse transcriptase activity in the MCF-7 breast cancer cell line. [PDF]

FEBS J
Sarkar G, Kundu S, Mukherjee SP, Goodier JL, Mandal PK.   +4 more
europepmc   +1 more source

Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches. [PDF]

Front Pharmacol
Mahendra FR, Prakoso I, Marzelino A, Rizqy Fadhillah M, Syukriyansyah, Hasibuan MMA, Suparningtyas JF, Kristiadi M, Setiawan AG, Rahman FI, Sari AN, Raysendria NR, Kurniawan I, Arozal W, Kusmardi K.   +14 more
europepmc   +1 more source

Telomerase Reverse Transcriptase-mutated Follicular Variant Papillary Thyroid Cancer With Tibial Metastasis. [PDF]

JCEM Case Rep
Chan N, Gilani S, Kim G, Madisi N.
europepmc   +1 more source