Telomere length and telomerase reverse transcriptase gene polymorphism as potential markers of complete chimerism and GvHD development after allogeneic haematopoietic stem cell transplantation. [PDF]
Dratwa-Kuzmin M+14 more
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The regulations of telomerase reverse transcriptase (TERT) in cancer. [PDF]
Liu M+7 more
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Association of telomerase reverse transcriptase gene rs10069690 variant with cancer risk: an updated meta-analysis. [PDF]
Zhou C+5 more
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Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase. [PDF]
Hoshino H+10 more
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Liver Damage During Treatment with Reverse-Transcriptase Inhibitors in HIV Patients. [PDF]
Lungu GN+7 more
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Reverse transcriptase in bacteria [PDF]
SummaryReverse transcriptase, discovered in 1970 in retroviruses, has until recently been found only in eukaryotic organisms. Recently it was shown to occur in two groups of bacteria: myxobacteria and Escherichia coli. The gene for reverse transcriptase is part of a chromosomal genetic element that codes for the production of a branched DNA‐RNA ...
Werner K. Maas, Dongbin Lim
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Summary Purified DNA polymerase (“reverse transcriptase”) from avian myeloblastosis virus was analyzed for zinc by atomic absorption spectroscopy. Tightly bound zinc was present in a stoichiometry approximating 1 gm atom/mole of enzyme. Inhibition by the chelating agent, ortho -phenanthroline, and lack of inhibition by its non-chelating analog ...
Narayana Battula+2 more
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The Discovery of Reverse Transcriptase
Annual Review of Virology, 2016In 1970 the independent and simultaneous discovery of reverse transcriptase in retroviruses (then RNA tumor viruses) by David Baltimore and Howard Temin revolutionized molecular biology and laid the foundations for retrovirology and cancer biology. In this historical review we describe the formulation of the controversial provirus hypothesis by Temin,
Hung Fan, John M. Coffin
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Retroviral reverse transcriptases
Cellular and Molecular Life Sciences, 2010Reverse transcription is a critical step in the life cycle of all retroviruses and related retrotransposons. This complex process is performed exclusively by the retroviral reverse transcriptase (RT) enzyme that converts the viral single-stranded RNA into integration-competent double-stranded DNA.
Alon Herschhorn, Amnon Hizi
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