Results 301 to 310 of about 1,758,180 (373)

Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase. [PDF]

PLoS Pathog
Aldunate M, Tyssen D, Johnson A, Latham CF, Ellenberg P, Cowieson N, Hayward JA, Center RJ, Ramsland PA, Hearps AC, Tachedjian G.   +10 more
europepmc   +1 more source

Human Lysozyme Transgenic Maize Improves Colonic Inflammation by Inhibiting the cGAS/STING Signaling Pathway in DSS‐Induced Colitis Mice

Food Frontiers, EarlyView.
Human lysozyme (HLZ) possesses the function of ameliorating intestinal inflammation. HLZ transgenic maize restored intestinal barrier function in colitis mice. HLZ‐feed inhibited the cGAS/STING signaling pathway by ameliorating DSS‐induced mitochondrial dysfunction.
Yinuo Yu, Yaqin Li, Xuan Chen, Rentao Song, Zhenyi Qiao, Weiwei Qi   +5 more
wiley   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Rare Structural Variants Uncovered by Optical Genome Mapping in Multisystem Inflammatory Syndrome in Children (MIS‐C)

Advanced Genetics, EarlyView.
This study applies optical genome mapping (OGM) to children with multisystem inflammatory syndrome (MIS‐C), revealing rare structural and copy number variants in and near immune‐related genes, including ORAI1, STAT4, ITPR1, BATF, CFHR5, and DOCK2.
Catherine A. Brownstein, Caspar I. van der Made, Kristin Cabral, Shira Rockowitz, Donghun Kang, Maximilian Schieck, Andy Wing Chun Pang, Jeffrey M. Robinson, Alex R. Hastie, Alka Chaubey, The C.O.V.I.D19hostgenomeS.V. Consortium, Alexander Hoischen, Alan H. Beggs, Clement A. Adebamowo, Ali Andalibi, Silviu‐Alin Bacanu, Vineet Bafna, Justin Bahl, Hayk Barseghyan, Alan Beggs, Laurie Burdette, Manish Butte, Pantelis Constantoulakis, Keith A. Crandall, Siavash R. Dehkordi, Megan Dennis, Gang Fang, Olivier Fedrigo, Darren Finlay, Michael A. Goldman, Umamaheswaran Gurusamy, Vanessa Hayes, Glenn Hickey, Alexander Hoischen, Thomas Illig, Alexander Ioannidis, Erich Jarvis, Naoru Koizumi, Ravindra Kolhe, Meriem Laamarti, Celia Labranche, Sandra Leibel, Brynn Levy, Matthew Loose, Claudio Mello, Jamal Nasir, Thuy L. Phung, Chethan P. Venkatasubba Rao, Ted Ross, Nikhil S. Sahajpal, Rashmi K. Shamanna, Daniela C. Soto, Amir Trablesi, Zi‐Xuan Wang, Sion Llewelyn Williams, Victoria Wright, Hua Zhao, Michael Zody   +57 more
wiley   +1 more source

An Exploratory Pharmacogenetic Pilot Study of Two Reverse Transcriptase Inhibitors, Tenofovir Alafenamide Fumarate and Tenofovir Disoproxil Fumarate. [PDF]

Drugs R D
Murrell DE, Kennard BC, Bertoni ME, Cluck DB, Moorman JP, Brown SD, Wang K, Duffourc MM, Harirforoosh S.   +8 more
europepmc   +1 more source

DOCKING STUDY OF METHYL HESPERIDIN AS NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR

, 2018
Hafrizal Riza, Andhi Fahrurroji, Arif Wicaksono, Ahmad Kharis Nugroho, Sudibyo Martono   +4 more
openalex   +2 more sources

From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes

Advanced Genetics, EarlyView.
This review begins with an introduction, summarizing the research background in pseudogene studies. It then contains three aspects: identification of pseudogenes, detailing their classification and features in metazoan genomes; functional pseudogenes, introducing their reactivation and regulation mechanisms; and pseudogenes’ contribution to species ...
Mengyao Sun, Yanni Ma, Jia Yu
wiley   +1 more source

De novo gene synthesis by an antiviral reverse transcriptase. [PDF]

Science
Tang S, Conte V, Zhang DJ, Žedaveinytė R, Lampe GD, Wiegand T, Tang LC, Wang M, Walker MWG, George JT, Berchowitz LE, Jovanovic M, Sternberg SH.   +12 more
europepmc   +1 more source

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing

Advanced Genetics, EarlyView.
This review examines recent advances in Oxford Nanopore Technologies direct RNA sequencing, highlighting its expanding capacity to detect RNA modifications beyond m6A. It discusses computational frameworks and basecalling innovations that enable single‐nucleotide and single‐molecule resolution, explores co‐occurring modifications and their regulatory ...
Yaran Liu, Yang Li, Qiang Sun
wiley   +1 more source

Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experienced Patients in Cameroon: Designing Future Treatment Strategies for Low- and Middle-Income Countries. [PDF]

Viruses
Nka AD, Bouba Y, Tsapi Lontsi WR, Gouissi Anguechia DH, Teto G, Ka'e AC, Semengue ENJ, Ambe Chenwi C, Takou D, Forgwei L, Tekoh TA, Ngueko AMK, Fokou BB, Efakika Gabisa J, Tchouaket MCT, TognaPabo WL, Ayuk Ngwese DT, Njiki Bikoi J, Armenia D, Colizzi V, Yotebieng M, Ndembi N, Santoro MM, Ceccherini-Silberstein F, Perno CF, Ndjolo A, Fokam J.   +26 more
europepmc   +1 more source