Results 61 to 70 of about 399,425 (291)

Functional Polymer Nanocomposites by Gas Aggregation Cluster Source and Initiated Chemical Vapor Deposition

Advanced Materials Technologies, EarlyView.
In this work, a gas aggregation cluster source and an initiated chemical vapor deposition are combined in a single vacuum reactor. With this setup polymer thin films can be combined with functional nanoparticles. As a proof‐of‐concept PTFE is combined with silver nanoparticles and tested in antibacterial, antiviral, and anticancer applications ...
Torge Hartig, Joschka Paulsen, Jonas Drewes, Asmaa T. Mohamed, Nasra F. Abdel Fattah, Cedric Hinrichs, Felix Pohl, Stefan Rehders, Ainura Aliyeva, Henning Wieker, Jörg Wiltfang, Salih Veziroglu, Samah A Loutfy, Oral Cenk Aktas, Alexander Vahl, Thomas Strunskus, Aydin Gülses, Amal Amin, Stefan Schröder, Franz Faupel   +19 more
wiley   +1 more source

Asymmetric conformational maturation of HIV-1 reverse transcriptase

eLife, 2015
HIV-1 reverse transcriptase utilizes a metamorphic polymerase domain that is able to adopt two alternate structures that fulfill catalytic and structural roles, thereby minimizing its coding requirements. This ambiguity introduces folding challenges that
Xunhai Zheng, Lalith Perera, Geoffrey A Mueller, Eugene F DeRose, Robert E London   +4 more
doaj   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Nil-reversible rings [PDF]

arXiv, 2021
This paper introduces and studies nil-reversible rings wherein we call a ring R nil-reversible if the left and right annihilators of every nilpotent element of R are equal. Reversible rings (and hence reduced rings) form a proper subclass of nil-reversible rings and hence we provide some conditions for a nil-reversible ring to be reduced.
arxiv  

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration

Advanced Science, EarlyView.
This study reveals that Kdm6a plays key roles in repressing either peripheral nervous system (PNS) or central nervous system (CNS) axon regeneration, whereas Kdm6b is not involved in regulating CNS axon regeneration. Moreover, both demethylases are able to regulate CNS neuronal survival after injury, but with non‐overlapping mechanisms.
Shu‐Guang Yang, Chang‐Ping Li, Xue‐Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling‐Rui Zhao, Si‐Yu Zhou, Chen‐Yun Ding, Rui Nie, Saijilafu, Yu‐Cai Hong, Chang‐Mei Liu, Feng‐Quan Zhou   +13 more
wiley   +1 more source

The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis. Matrix metalloproteinases (MMPs) and Hsp90 chaperone are implicated in tumor progression, however, they are not studied in the context of drug resistance. Aims In the present study, we aimed at
Pankaj Kumar, Satish Siripini, Amere Subbarao Sreedhar   +2 more
wiley   +1 more source

A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.

PLoS Biology, 2019
Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells.
Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J Robinson, William P Schiemann, Anthony J Berdis, Emmanuel Skordalakes, Derek J Taylor   +8 more
doaj   +1 more source

One-Step Fluorescent Probe Product-Enhanced Reverse Transcriptase Assay

BioTechniques, 1998
Recently developed PCR-based reverse transcriptase (RT) assays are useful in the detection of retroviruses since they are approximately a millionfold more sensitive than conventional RT assays.
Beth A. Arnold, Robert W. Hepler, Paul M. Keller   +2 more
doaj   +1 more source

A New DNA Sequences Vector Space on a Genetic Code Galois Field [PDF]

The final version of the paper is published in the journal: MATCH Commun. Math. Comput. Chem. Volume 54 (2005), number 1 , pp. 3-28., 2004
A new n-dimensional vector space of the DNA sequences on the Galois field of the 64 codons (GF(64)) is proposed. In this vector space gene mutations can be considered linear transformations or translations of the wild type gene. In particular, the set of translations that preserve the chemical type of the third base position in the codon is a subgroup ...
arxiv  

Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells

Advanced Science, EarlyView.
Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang, Jane Frederick, Karla Isabel Medina, Elizabeth Thomas Bartom, Luay Matthew Almassalha, Yaqi Zhang, Greta Wodarcyk, Hao Huang, I Chae Ye, Ruyi Gong, Cody Levi Dunton, Alex Duval, Paola Carrillo Gonzalez, Joshua Pritchard, John Carinato, Iuliia Topchu, Junzui Li, Zhe Ji, Mazhar Adli, Vadim Backman, Daniela Matei   +20 more
wiley   +1 more source