PharmaceuticalsBrain somatic gene recombination (SGR) and the endogenous reverse transcriptases (RTs) that produce it have been implicated in the etiology of Alzheimer’s disease (AD), suggesting RT inhibitors as novel prophylactics or therapeutics.
Tiffany W. Chow +5 more
doaj +1 more source
Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
Front. Cell Dev. Biol., 2017 Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase ...
Ekta Khattar, V. Tergaonkar
semanticscholar +1 more source
Factors Associated with the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study [PDF]
, 2017 Background. Human immunodeficiency virus (HIV)-infected persons may be at increased risk for developing type 2 diabetes mellitus because of viral coinfection and adverse effects of treatment. Methods.
Bernasconi, Enos +10 more
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Antiretroviral treatment can affect the release of NO and EDCF, but EDH in rat arteries [PDF]
, 2012 This journal suppl. entitled: EDHF 2012 - 10th Anniversary MeetingDespite improving clinical outcomes, highly active antiretroviral therapy (HAART) is an independent potential risk factor for cardiovascular diseases.
Lee, SS +3 more
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Potential to use of viral reverse transcriptase inhibitors in oncology
Успехи молекулярной онкологииIn preparing the review, articles on the functioning of the reverse transcriptase enzyme of endogenous repeat sequences LINE1, the mechanisms of action and antitumor activity of viral reverse transcriptase inhibitors. Articles available in the biomedical
O. A. Vlasova +7 more
doaj +1 more source
Structure of a Group II Intron Complexed with its Reverse Transcriptase
Nature Structural & Molecular Biology, 2016 Bacterial group II introns are large catalytic RNAs related to nuclear spliceosomal introns and eukaryotic retrotransposons. They self-splice to yield mature RNA, and integrate into DNA as retroelements.
Guosheng Qu +7 more
semanticscholar +1 more source
Reverse transcriptase at bacterial telomeres [PDF]
Proceedings of the National Academy of Sciences, 2004 I n the past two decades, intense efforts have been devoted to uncovering the mechanisms responsible for the maintenance of telomeres in eukaryotic cells. These efforts have led to the identification of an unusual reverse transcriptase (RT), named telomerase, that uses an integral RNA subunit as template to synthesize a short reiterated sequence at the
Neal F, Lue, Sulin, Jiang
openaire +2 more sources
4′-Acylated thymidine 5′-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase [PDF]
, 2017 4′-Acylated thymidines represent a new class of DNA chain terminators, since they have been shown to act as post-incorporation chain-terminating nucleotides despite the presence of a free 3′-hydroxyl group. Here, we describe the action of the 4′-acetyl- (
Amacker, Mario +5 more
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Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-Naïve chronic HBV patients [PDF]
, 2013 Background: Immunomodulators and Nucleotide analogues have been used globally for the dealing of chronic hepatitis B virus (HBV) infection. However, the development of drug resistance is a major limitation to their long-term effectiveness.
Abedi, F. +33 more
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