Results 71 to 80 of about 1,721,781 (403)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Initiation of HIV Reverse Transcription

Viruses, 2010
Reverse transcription of retroviral genomes into double stranded DNA is a key event for viral replication. The very first stage of HIV reverse transcription, the initiation step, involves viral and cellular partners that are selectively packaged into the
Roland Marquet, Chantal Ehresmann, Catherine Isel   +2 more
doaj   +1 more source

Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]

, 2009
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core   +1 more source

Structural basis of template-boundary definition in Tetrahymena telomerase. [PDF]

, 2015
Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template.
Akiyama, Ben M, Jansson, Linnea I, Lu, Cheng, Ooms, Alexandra, Rubin, Seth M, Stone, Michael D   +5 more
core   +2 more sources

Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression.

Journal of Clinical Investigation, 2016
Transcriptional reactivation of telomerase reverse transcriptase (TERT) reconstitutes telomerase activity in the majority of human cancers. Here, we found that ectopic TERT expression increases cell proliferation, while acute reductions in TERT levels ...
Ekta Khattar, Pavanish Kumar, Chia-yi Liu, S. C. Akıncılar, Anandhkumar Raju, Manikandan Lakshmanan, Julien Jean Pierre Maury, Yu Qiang, Shang Li, E. Tan, K. Hui, Minghao Shi, Joey Loh, V. Tergaonkar   +13 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase

Viruses, 2022
Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol precursor intermediates, in which RT and IN are in fusion form (RTIN) to exert ...
Takao Masuda, Osamu Kotani, Masaru Yokoyama, Yuya Abe, Gota Kawai, Hironori Sato   +5 more
doaj   +1 more source

Anti-HIV-1 activity of benzothiadiazine dioxide [PDF]

, 2013
Antiviral assays carried out on the potent benzothiadiazine dioxide (BTD) human cytomegalovirus (HCMV) inhibitors have led us to find marginal but selective anti-HIV-1 activity.
Balzarini, Jan, Castro, Ana, De Clercq, Erik, Gil, Carmen, Martínez, Ana, Pannecouque, C., Pérez, Concepción, Witvrouw, M.   +7 more
core   +2 more sources

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation

Journal of Virology, 2016
HIV-1 protease (PR), reverse transcriptase (RT), and integrase (IN) variability presents a challenge to laboratories performing genotypic resistance testing.
Soo-Yon Rhee, Kris Sankaran, V. Varghese, M. Winters, C. Hurt, J. Eron, N. Parkin, S. Holmes, M. Holodniy, R. Shafer   +9 more
semanticscholar   +1 more source

Phosphonoformate Inhibits Reverse Transcriptase

Journal of General Virology, 1979
The new antiviral substance phosphonoformate (PFA) has been tested in a cell-free system for its effect on reverse transcriptases from an avian retrovirus (avian myeloblastosis virus, AMV) and from mammalian retroviruses (Rauscher leukaemia virus, RMuLV; bovine leukaemia virus; baboon endogenous virus; simian sarcoma virus; visna virus).
Bo Sundquist, Bo Öberg
openaire   +3 more sources